1996
The biological basis of panic disorder.
Krystal JH, Deutsch DN, Charney DS. The biological basis of panic disorder. The Journal Of Clinical Psychiatry 1996, 57 Suppl 10: 23-31; discussion 32-3. PMID: 8917129.Peer-Reviewed Original ResearchConceptsPanic disorderMultiple neuronal systemsRelated brain regionsFunctional imaging studiesOvert historyPharmacologic mechanismsTreatment optionsPharmacologic challengePanicogenic agentPreclinical investigationsNeurochemical substratesPanic attacksChallenge studiesBrain regionsImaging studiesAnatomical basisNeuronal systemsAnxiety disordersDisordersHeritable predispositionBiological basisFurther evidence
1989
Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects
Woods S, Krystal J, Heninger G, Charney D. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. Life Sciences 1989, 45: 233-242. PMID: 2503670, DOI: 10.1016/0024-3205(89)90255-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlprazolamAnxietyCarbon DioxideClonidineFemaleHumansMalePulseReference ValuesTidal VolumeConceptsHealthy human subjectsClonidine 2 mcg/Pulse rateEffects of alprazolamAnxiety-like effectsHuman subjectsRatings of anxietyOral alprazolamHypotensive effectVentilatory responseMcg/Noradrenergic systemBenzodiazepine receptorsAnxiolytic propertiesNeurobiologic mechanismsClonidineNew drugsAlprazolamAnxiety ratingsSubjective anxietyDrugsAnxietyNormal functioningNeural systemsUseful model systemThe effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey
Krystal J, Woods S, Levesque M, Heninger C, Heninger G. The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey. Life Sciences 1989, 45: 1657-1663. PMID: 2511388, DOI: 10.1016/0024-3205(89)90275-0.Peer-Reviewed Original ResearchConceptsGrowth hormonePlasma MHPGChair-adapted rhesus monkeysRespiratory rateRhesus monkeysSignificant dose-dependent increaseEffects of inhalationDose-dependent increaseCarbon dioxide inhalationNorepinephrine metabolitePlasma levelsPlasma hormonesMHPGBehavioral activationInhalationHormoneProlactinShort durationCortisolMonkeysMinutesPeak changes
1988
A review of behavioral and pharmacologic studies relevant to the application of CO2 as a human subject model of anxiety.
Woods SW, Krystal JH, D'Amico CL, Heninger GR, Charney DS. A review of behavioral and pharmacologic studies relevant to the application of CO2 as a human subject model of anxiety. Psychopharmacology Bulletin 1988, 24: 149-53. PMID: 3133718.Peer-Reviewed Original Research