2022
Post-traumatic Stress Disorder
Merians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderStress disorderCognitive processing therapyCognitive behavioral therapyEye movement desensitizationEvidence-based psychotherapiesTraumatic eventsBehavioral therapyNegative alterationsFirst-line pharmacologic treatmentStructured interviewsFirst-line treatmentNonpsychiatric settingsLarge bodyPharmacologic treatmentReuptake inhibitorsCognitionDisordersArousalTherapeutic interventionsMoodPsychotherapyAvoidanceTherapyIntervention
1999
Neurotransmitter alterations in PTSD: catecholamines and serotonin.
Southwick SM, Paige S, Morgan CA, Bremner JD, Krystal JH, Charney DS. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars In Clinical Neuropsychiatry 1999, 4: 242-8. PMID: 10553029, DOI: 10.153/scnp00400242.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderIntrusive memoriesLevel of alertnessSelective attentionAuditory remindersLife-threatening stimuliStress disorderCatecholamine dysregulationUrine catecholamine excretionExaggerated reactivityDepressed moodExaggerated startlePlatelet paroxetine bindingSerotonergic dysregulationAggressionClinical efficacyImpulsivityMotor outputBlunted prolactin responseMemoryMoodSerotonin reuptake inhibitorsAdrenergic receptor numberCentral catecholamine neuronsCentral nervous system
1992
Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function?
Krystal J, Price L, Opsahl C, Ricaurte G, Heninger G. Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function? The American Journal Of Drug And Alcohol Abuse 1992, 18: 331-341. PMID: 1357957, DOI: 10.3109/00952999209026070.Peer-Reviewed Original ResearchConceptsNeuropsychological functionMDMA useChronic MDMA useWechsler Memory ScaleLeast mild impairmentMemory ScaleNeuropsychological batteryTime of testingMood effectsCognitive functionMemory deficitsMethylenedioxymethamphetamine (MDMA) useDepressed moodMood regulationPreliminary evidenceDeficitsMild impairmentClinical criteriaClinical examinationPreliminary findingsSelective serotoninMoodModerate impairmentAffective disordersPossible detrimental effects