2006
GENETIC STUDY: Analysis of variations in the tryptophan hydroxylase‐2 (TPH2) gene in cocaine dependence
Dahl JP, Cubells JF, Ray R, Weller AE, Lohoff FW, Ferraro TN, Oslin DW, Kampman KM, Dackis C, Tang Y, Gelernter J, Kranzler HR, O’Brien C, Berrettini WH. GENETIC STUDY: Analysis of variations in the tryptophan hydroxylase‐2 (TPH2) gene in cocaine dependence. Addiction Biology 2006, 11: 76-83. PMID: 16759340, DOI: 10.1111/j.1369-1600.2006.00005.x.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsCocaine dependenceTryptophan hydroxylase 2 geneTPH2 geneGenetic variationCase-control study designSerotonergic neurotransmitter systemCentral nervous systemSubstance use disordersGenesExact physiological mechanismsNucleotide polymorphismsAnalysis of variationPhysiological mechanismsControl subjectsBody of evidenceRisk factorsNeurotransmitter systemsUse disordersNervous systemStudy designAllele distributionPresent studyAfrican descentStudy associates
2001
Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents
Zalsman G, Frisch A, King R, Pauls D, Grice D, Gelernter J, Alsobrook J, Michaelovsky E, Apter A, Tyano S, Weizman A, Leckman J. Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents. American Journal Of Medical Genetics 2001, 105: 451-457. PMID: 11449398, DOI: 10.1002/ajmg.1406.Peer-Reviewed Original ResearchConceptsSuicidal behaviorSuicide riskA218C polymorphismDetailed clinical historyHaplotype relative riskAssociation of suicidalityTransmission disequilibrium test (TDT) methodsTryptophan hydroxylase geneAdolescent suicidal behaviorClinical historySame ethnic populationRelative riskCase controlAA genotypeControl groupFamily-based studySuicide intentSignificant allelic associationSignificant differencesEthnic populationsStructured interviewsInpatient adolescentsRiskAssociationSuicidality
1998
Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF))
Gelernter J, Kranzler H, Lacobelle J. Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF)). Genomics 1998, 52: 289-297. PMID: 9790747, DOI: 10.1006/geno.1998.5454.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApolipoproteins ECarrier ProteinsCiliary Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsGenetics, PopulationGenotypeHumansMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPolymorphism, GeneticReceptors, Dopamine D2Receptors, Dopamine D3Receptors, Opioid, muTryptophan HydroxylaseConceptsCiliary neurotrophic factorTryptophan hydroxylase genotype is associated with impulsive‐aggression measures: a preliminary study
New A, Gelernter J, Yovell Y, Trestman R, Nielsen D, Silverman J, Mitropoulou V, Siever L. Tryptophan hydroxylase genotype is associated with impulsive‐aggression measures: a preliminary study. American Journal Of Medical Genetics 1998, 81: 13-17. PMID: 9514581, DOI: 10.1002/(sici)1096-8628(19980207)81:1<13::aid-ajmg3>3.0.co;2-o.Peer-Reviewed Original ResearchMeSH KeywordsAdultAggressionFemaleFenfluramineGenotypeHumansImpulsive BehaviorMaleProlactinSelective Serotonin Reuptake InhibitorsSerotoninTryptophan HydroxylaseConceptsProlactin responseTPH genotypeTryptophan hydroxylase genotypePersonality disorder patientsImpulsive aggressive behaviorBuss-Durkee Hostility InventoryMale patientsCaucasian patientsDisorder patientsFenfluraminePatientsImpulsive aggressionPersonality disorderHostility InventoryPreliminary studyBDHI scoresGenotypesResponse
1997
Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients
Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. American Journal Of Psychiatry 1997, 154: 1451-1453. PMID: 9326831, DOI: 10.1176/ajp.154.10.1451.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesDepressive DisorderFamilyFemaleGene FrequencyHospitalizationHumansMalePolymorphism, GeneticRegression AnalysisSuicideTryptophan Hydroxylase