2017
Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol‐Response Behaviors in Model Organisms
Adkins AE, Hack LM, Bigdeli TB, Williamson VS, McMichael GO, Mamdani M, Edwards AC, Aliev F, Chan RF, Bhandari P, Raabe RC, Alaimo JT, Blackwell GG, Moscati A, Poland RS, Rood B, Patterson DG, Walsh D, Consortium C, Whitfield JB, Zhu G, Montgomery GW, Henders AK, Martin NG, Heath AC, Madden PAF, Frank J, Ridinger M, Wodarz N, Soyka M, Zill P, Ising M, Nöthen MM, Kiefer F, Rietschel M, Consortium T, Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA, Maher BS, Prescott CA, Dick DM, Bacanu SA, Mathies LD, Davies AG, Vladimirov VI, Grotewiel M, Bowers MS, Bettinger JC, Webb BT, Miles MF, Kendler KS, Riley BP. Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol‐Response Behaviors in Model Organisms. Alcohol Clinical And Experimental Research 2017, 41: 911-928. PMID: 28226201, PMCID: PMC5404949, DOI: 10.1111/acer.13362.Peer-Reviewed Original ResearchConceptsModel organismsGenomewide association studiesLoss of functionAssociation studiesPrimate-specific genesAcute functional toleranceOrthologous genesCaenorhabditis elegansSuggestive signalsOrthologsExpression differencesGene expressionCOL6A3 expressionGenesAlcohol dependenceNucleus accumbensKLF12 expressionSuggestive associationElegansCOL6A3AD liabilityPotential involvementMultiple brain functionsEtOH sensitivityKLF12
2006
Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia
Malison RT, Kranzler HR, Yang BZ, Gelernter J. Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. Psychiatric Genetics 2006, 16: 245-249. PMID: 17106427, DOI: 10.1097/01.ypg.0000242198.59020.ca.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsNucleotide polymorphismsCircadian rhythm genesDrosophila melanogasterHuman orthologGenetic variationCocaine-induced paranoiaGenetic mechanismsRhythm genesGene single nucleotide polymorphismsPopulation comparisonsHuman clockLack of associationPotential involvementAllelic associationClinical featuresAllele frequenciesStimulant exposureBehavioral sensitizationLocomotor sensitizationPsychostimulant addictionDrug useClinical phenotypeCocaine dependencePER2 polymorphisms