Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT.
Moo-Choy A, Stein M, Gelernter J, Wendt F. Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT. The Canadian Journal Of Psychiatry 2024, 7067437241301016. PMID: 39654303, PMCID: PMC11629358, DOI: 10.1177/07067437241301016.Peer-Reviewed Original ResearchGenome-wide association studiesGenome-wide significant lociSignificant lociMultivariate genome-wide association studyIndividuals of European ancestryPosttraumatic stress disorderGenomic structural equation modelingPosttraumatic stressUK Biobank (UKBAssociation studiesGenetic basisSymptom combinationsEtiological differencesSex-specific patternsEuropean ancestryAssociation dataPosttraumatic stress disorder diagnosisPosttraumatic stress disorder symptomsSex differencesLociInvestigation of sex differencesGeneticsSymptom etiologyModel of maleTraumatic eventsDistinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records
Løkhammer S, Koller D, Wendt F, Choi K, He J, Friligkou E, Overstreet C, Gelernter J, Hellard S, Polimanti R. Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records. Psychiatry Research 2024, 337: 115950. PMID: 38744179, PMCID: PMC11156529, DOI: 10.1016/j.psychres.2024.115950.Peer-Reviewed Original ResearchElectronic health recordsPosttraumatic stress disorderHealth recordsPTSD vulnerabilityUK Biobank (UKBPhenome-wide association studyRisk scorePhenotype risk scoreUs Research ProgramPolygenic risk scoresStress disorderAoU participantsUKB participantsPresence of posttraumatic stress disorderTrauma burdenGenetic riskPosttraumatic stress disorder symptomsAssociation studiesPheWASClinical comorbiditiesComorbid associationsEye conditionsAOUInverse relationshipMultiple phenotypes