2024
Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits
Hartwell E, Jinwala Z, Milone J, Ramirez S, Gelernter J, Kranzler H, Kember R. Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits. Neuropsychopharmacology 2024, 49: 1958-1967. PMID: 39043921, PMCID: PMC11480112, DOI: 10.1038/s41386-024-01922-2.Peer-Reviewed Original ResearchSubstance use disordersPost-traumatic stress disorderGeneralized anxiety disorderGenetic liabilityPolygenic scoresBipolar disorderSubstance use phenotypesSomatic traitsBody mass indexSubstance use categoriesEffect of genetic liabilityAnxiety disordersDepression-relatedDepressive disorderApplication of polygenic scoresStress disorderPsychiatric disordersPsychiatric phenotypesUse disorderPhenome-wide association studyGenetic influencesCross-sectional sampleMedical illnessPrecision medicine effortsPhenotyped sample
2009
NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adults
Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adults. Depression And Anxiety 2009, 27: 270-275. PMID: 20037921, PMCID: PMC2879267, DOI: 10.1002/da.20648.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderNeuropeptide YEpidemiologic sampleGAD diagnosisHurricane exposureAnxiety disordersRandom digit dial proceduresHigh hurricane exposureFlorida Hurricane StudyFunctional single nucleotide polymorphismsNPY rs16147NPY expressionOutcome measuresGene-environment interactionsStressor exposureBuccal DNA samplesSingle nucleotide polymorphismsGAD symptomsRs16147AdultsStructured interviewsExposureDiagnosisRiskDisorders
2008
RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adults
Koenen KC, Amstadter AB, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adults. Depression And Anxiety 2008, 26: 309-315. PMID: 18833580, PMCID: PMC2666784, DOI: 10.1002/da.20528.Peer-Reviewed Original ResearchConceptsEpidemiologic sampleC alleleAnxiety disordersRisk of GADRandom digit dial proceduresSingle nucleotide polymorphismsLogistic regression analysisPanic disorder patientsDSM-IV diagnosisGeneralized anxiety disorderHurricane exposureFlorida Hurricane StudyRGS2 geneSocial supportStressful life eventsHigh prevalenceOutcome measuresDisorder patientsPanic disorderBuccal DNA samplesRelevant polymorphismsDisordersGADAnxious behaviorGAD symptoms