2007
Variation in GABRA2 Predicts Drinking Behavior in Project MATCH Subjects
Bauer LO, Covault J, Harel O, Das S, Gelernter J, Anton R, Kranzler HR. Variation in GABRA2 Predicts Drinking Behavior in Project MATCH Subjects. Alcohol Clinical And Experimental Research 2007, 31: 1780-1787. PMID: 17949392, PMCID: PMC3169387, DOI: 10.1111/j.1530-0277.2007.00517.x.Peer-Reviewed Original ResearchConceptsTwelve-step facilitationMotivational enhancement therapyCognitive behavioral therapyPsychosocial treatmentsSingle nucleotide polymorphismsAlcohol dependenceGABRA2 single nucleotide polymorphismsMulti-center randomized clinical trialHeavy drinkingRandomized clinical trialsLow-risk allelesPost-treatment periodPresent studyClinical trialsLower riskEuropean-American subjectsAlcoholism treatmentBehavioral therapyGABRA2 genotypeGABRA2 geneEnhancement therapyLower daily probabilityDrinking outcomesGenetic vulnerabilityPrevious studies
2004
Allelic and haplotypic association of GABRA2 with alcohol dependence
Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR. Allelic and haplotypic association of GABRA2 with alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 129B: 104-109. PMID: 15274050, DOI: 10.1002/ajmg.b.30091.Peer-Reviewed Original ResearchConceptsAlcohol-dependent subjectsAlcohol dependenceSingle nucleotide polymorphismsMajor depressive episodeGABAA receptor subunitsSubstance use disordersHaplotypic associationsEvidence of associationSerious morbidityOpioid dependenceAlpha 2 subunitDepressive episodePrevalent disorderUse disordersEuropean-American subjectsNeurotransmitter receptorsControl groupDrug dependenceReceptor subunitsCommon haplotypeGABRA2 geneBehavioral effectsImportant mediatorAssociationSubjects