2009
BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study
Zdanys KF, Kleiman TG, Zhang H, Ozbay F, MacAvoy MG, Gelernter J, van Dyck CH. BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study. Journal Of Alzheimer's Disease 2009, 17: 887-898. PMID: 19542613, PMCID: PMC4084650, DOI: 10.3233/jad-2009-1106.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAllelesAlzheimer DiseaseBrain-Derived Neurotrophic FactorCognitionDisease ProgressionEducational StatusFemaleGene FrequencyGenetic Predisposition to DiseaseHallucinationsHumansMalePolymerase Chain ReactionPolymorphism, Single NucleotidePrevalenceRetrospective StudiesSeverity of Illness IndexConceptsBrain-derived neurotrophic factorNeuropsychiatric symptomsAlzheimer's diseaseBDNF polymorphismFunctional declineRole of BDNFMultiple subsequent time pointsVal/Val groupBDNF genetic variantsC270T polymorphismPresence of hallucinationsMet/MetSubsequent time pointsVal/MetBDNF variantsClinical courseVal66Met genotypeVal66Met polymorphismC270TDisease characteristicsNeurotrophic factorTests of cognitionNeuronal survivalAD patientsHigh prevalence
2008
Correlates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders
Arias AJ, Gelernter J, Chan G, Weiss RD, Brady KT, Farrer L, Kranzler HR. Correlates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders. Addictive Behaviors 2008, 33: 1199-1207. PMID: 18558465, PMCID: PMC2532519, DOI: 10.1016/j.addbeh.2008.05.003.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderFirst substance useOpioid dependenceLifetime diagnosisSubstance useCo-occurring attention-deficit hyperactivity disorderSubstance dependence disordersDrug-dependent subjectsSemi-Structured AssessmentDeficit hyperactivity disorderClinical courseMore hospitalizationsSevere coursePsychiatric comorbiditySD diagnosisDependence disordersPsychiatric disordersADHD prevalencePsychiatric diagnosisDrug dependenceMore SDsSubstance dependenceConduct disorderDiagnosisHyperactivity disorder