2022
Comprehensive assessment of neurocognitive function, inflammation markers, and adiposity in treated HIV and control
Mouchati C, Kamari V, Sattar A, Yu J, McComsey G. Comprehensive assessment of neurocognitive function, inflammation markers, and adiposity in treated HIV and control. Medicine 2022, 101: e31125. PMID: 36281153, PMCID: PMC9592384, DOI: 10.1097/md.0000000000031125.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusImmunodeficiency virusNeurocognitive impairmentUndetectable HIV-1 RNA levelsHIV-1 RNA levelsHigh inflammatory markersMarkers of inflammationBody fat compositionVisceral adipose tissueCross-sectional studyBody composition measuresChi-square testHigher total fatInflammatory markersInflammation markersCentral adiposityHIV statusImmune activationInsulin resistanceMean agePLWHHeroin useAdipose tissueDrug AdministrationNeurocognitive functionAmbient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents
Toe S, Nagy M, Albar Z, Yu J, Sattar A, Nazzinda R, Musiime V, Etajak S, Walyawula F, McComsey G, Atuyambe L, Dirajlal-Fargo S. Ambient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents. AIDS 2022, 36: 863-870. PMID: 35131961, PMCID: PMC9081159, DOI: 10.1097/qad.0000000000003186.Peer-Reviewed Original ResearchConceptsIntima-media thicknessVascular diseaseMonocyte activationCarotid intima-media thicknessSubclinical vascular diseaseHIV-positive adolescentsMarkers of inflammationEffects of HIVCross-sectional studyMultivariable quantile regression modelsMultivariable quantile regressionAmbient air pollutionDaily ambient concentrationsDaily PM2.5 exposureExposure of PM2.5Systemic inflammationMedian ageSoluble CD163Atherosclerotic diseasePlasma markersIntestinal permeabilityCardiovascular diseaseGut integrityHIVPM2.5 exposure
2021
Lipidome association with vascular disease and inflammation in HIV+ Ugandan children
Dirajlal-Fargo S, Sattar A, Yu J, Albar Z, Chaves F, Riedl K, Kityo C, Bowman E, McComsey G, Funderburg N. Lipidome association with vascular disease and inflammation in HIV+ Ugandan children. AIDS 2021, 35: 1615-1623. PMID: 33878042, PMCID: PMC8286331, DOI: 10.1097/qad.0000000000002923.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyT cell activationCardiovascular diseaseVascular diseaseCommon carotid artery intimaSubclinical vascular diseaseSerum lipid compositionCarotid artery intimaYears of ageLipid speciesART regimenCVD riskSystemic inflammationHIV infectionMedian ageImmune activationActive infectionPlasma markersSerum lipidomeArtery intimaUgandan childrenCopies/Monocyte activationFree fatty acidsLipid classes
2020
Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction.
Dirajlal-Fargo S, Yu J, Albar Z, Sattar A, Mahtab S, Jao J, Myer L, Zar H, McComsey G. Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction. AIDS 2020, 34: 1615-1623. PMID: 32769763, PMCID: PMC9390079, DOI: 10.1097/qad.0000000000002615.Peer-Reviewed Original ResearchConceptsReactive hyperemic indexGut barrier dysfunctionPoorer endothelial functionEndothelial dysfunctionMonocyte activationHIV- youthEndothelial functionBarrier dysfunctionAntiretroviral therapyLDL cholesterolLong-term clinical significanceCape Town Adolescent Antiretroviral CohortAntiretroviral therapy durationYears of ageViral suppressionHyperemic indexSystemic inflammationTherapy durationHIV- participantsMedian ageSpearman correlation coefficientViral loadSerum biomarkersSoluble CD14YLPHIV
2019
Brief Report: Zinc Supplementation and Inflammation in Treated HIV.
Dirajlal-Fargo S, Yu J, Kulkarni M, Sattar A, Funderburg N, Barkoukis H, Mccomsey G. Brief Report: Zinc Supplementation and Inflammation in Treated HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: 275-280. PMID: 31609926, PMCID: PMC6812547, DOI: 10.1097/qai.0000000000002129.Peer-Reviewed Original ResearchConceptsZinc supplementationZinc levelsDouble-arm studyHigh-dose armLow-dose armMedian zinc levelStable antiretroviral therapyMarkers of inflammationYears old peopleTreated HIVAntiretroviral therapyHIV infectionMedian ageClinical comorbiditiesBiomarker levelsMonocyte activationLarge effect sizesHIVInflammationPilot studyPhase ISupplementationDlElemental zincAfrican Americans