Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction.
Dirajlal-Fargo S, Yu J, Albar Z, Sattar A, Mahtab S, Jao J, Myer L, Zar H, McComsey G. Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction. AIDS 2020, 34: 1615-1623. PMID: 32769763, PMCID: PMC9390079, DOI: 10.1097/qad.0000000000002615.Peer-Reviewed Original ResearchConceptsReactive hyperemic indexGut barrier dysfunctionPoorer endothelial functionEndothelial dysfunctionMonocyte activationHIV- youthEndothelial functionBarrier dysfunctionAntiretroviral therapyLDL cholesterolLong-term clinical significanceCape Town Adolescent Antiretroviral CohortAntiretroviral therapy durationYears of ageViral suppressionHyperemic indexSystemic inflammationTherapy durationHIV- participantsMedian ageSpearman correlation coefficientViral loadSerum biomarkersSoluble CD14YLPHIV