The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms
Xiao C, Fedirko V, Beitler J, Bai J, Peng G, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Jeon S, Knobf TM, Conneely KN, Higgins K, Shin DM, Saba N, Miller A, Bruner D. The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms. Supportive Care In Cancer 2020, 29: 3173-3182. PMID: 33078326, PMCID: PMC8055716, DOI: 10.1007/s00520-020-05820-3.Peer-Reviewed Original ResearchConceptsCancer-related fatigueGut microbiomePilot studyHigh-fatigue groupLow-fatigue groupsGut-brain axisMultidimensional Fatigue InventoryGut microbiota patternBrain healthCancer patientsFatigue InventoryNeck cancerPurposeRecent evidenceStool samplesImmune responseMicrobiota patternsGut microbiotaInflammationOne monthBrain functionPatientsConclusionsOur resultsFatty acid synthesisEPIC BeadChipDNA methylation changesGut Microbiome Associated with the Psychoneurological Symptom Cluster in Patients with Head and Neck Cancers
Bai J, Bruner DW, Fedirko V, Beitler JJ, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Higgins KA, Shin DM, Saba NF, Miller AH, Xiao C. Gut Microbiome Associated with the Psychoneurological Symptom Cluster in Patients with Head and Neck Cancers. Cancers 2020, 12: 2531. PMID: 32899975, PMCID: PMC7563252, DOI: 10.3390/cancers12092531.Peer-Reviewed Original ResearchPsychoneurological symptomsCancer patientsGut microbiomeNeck cancerPost-radiation therapyPsychoneurological symptom clusterCommon Terminology CriteriaPatient gut microbiomeGut Microbiome AssociatedFunctional pathway analysisTerminology CriteriaAdverse eventsOutcomes versionDiscriminant analysis effect sizeLinear discriminant analysis effect sizeStool specimensPatientsSymptom clustersCancer treatmentPilot studyGreater decreaseVitamin metabolismPotential rolePreliminary dataSignificant differences