2018
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira
Adhikarla H, Wunder EA, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI. Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira. Frontiers In Cellular And Infection Microbiology 2018, 8: 45. PMID: 29600195, PMCID: PMC5863495, DOI: 10.3389/fcimb.2018.00045.Peer-Reviewed Original ResearchConceptsResponse regulatorTwo-component system proteinsDNA-binding response regulatorGlobal transcriptional regulationHybrid histidine kinaseGlobal gene regulationNovel signal pathwayComprehensive genomic analysisPhosphotransfer assaysTCS genesHistidine kinaseGene duplicationTranscriptional regulationGene regulationCorresponding genesPhylogenetic analysisGenomic analysisMolecular basisMutant strainSystem proteinsSignaling systemInfection processGenesBranched pathwayVirulence
2015
Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola
Sistrom M, Park D, O’Brien H, Wang Z, Guttman DS, Townsend JP, Turner PE. Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola. PLOS ONE 2015, 10: e0144514. PMID: 26670219, PMCID: PMC4687649, DOI: 10.1371/journal.pone.0144514.Peer-Reviewed Original ResearchMeSH KeywordsBacteriophagesBinding SitesCitric Acid CycleFimbriae, BacterialGene Expression ProfilingGene Expression Regulation, BacterialGenomicsMutationPseudomonas syringaeRegulonConceptsGene OntologyGene expression variationType IV pilus expressionGene expression comparisonsType IV piliTricarboxylic acid cycle (TCA) cycleType IV pilusNon-piliated strainsPseudomonas syringae pathovar phaseolicolaAcetyl-CoA metabolismEvolutionary biologyTCA pathwayExpression analysisPilus retractionPilus mutantsExpression variationExpression patternsWild typeAerobic respirationGenome sequencingSignificant bacterial pathogensPilus expressionDifferential expressionBacterial cellsPathovar phaseolicola