Featured Publications
The durability of natural infection and vaccine-induced immunity against future infection by SARS-CoV-2
Townsend JP, Hassler HB, Sah P, Galvani AP, Dornburg A. The durability of natural infection and vaccine-induced immunity against future infection by SARS-CoV-2. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2204336119. PMID: 35858382, PMCID: PMC9351502, DOI: 10.1073/pnas.2204336119.Peer-Reviewed Original ResearchThe durability of immunity against reinfection by SARS-CoV-2: a comparative evolutionary study
Townsend JP, Hassler HB, Wang Z, Miura S, Singh J, Kumar S, Ruddle NH, Galvani AP, Dornburg A. The durability of immunity against reinfection by SARS-CoV-2: a comparative evolutionary study. The Lancet Microbe 2021, 2: e666-e675. PMID: 34632431, PMCID: PMC8486316, DOI: 10.1016/s2666-5247(21)00219-6.Peer-Reviewed Original ResearchConceptsDurability of immunitySARS-CoV-2Human-infecting coronavirusesProbability of reinfectionAntibody levelsMERS-CoVSARS-CoVLong-term immune responsePeak antibody responsePublic health decision makingCOVID-19 pandemic continuesEndemic conditionsCOVID-19 morbidityPublic health measuresVirus SARS-CoVHealth decision makingOptical density levelsDevastating COVID-19 pandemicAntibody declineLikely reinfectionAntibody responseEndemic coronavirusesHCoV-NL63Immune responseHuman coronavirusesSeasonality of endemic COVID-19
Townsend J, Hassler H, Lamb A, Sah P, Nishio A, Nguyen C, Tew A, Galvani A, Dornburg A. Seasonality of endemic COVID-19. MBio 2023, 14: e01426-23. PMID: 37937979, PMCID: PMC10746271, DOI: 10.1128/mbio.01426-23.Peer-Reviewed Original ResearchPublic health interventionsSARS-CoV-2Health interventionsSARS-CoV-2 infectionCOVID-19SARS-CoV-2 circulationEffective public health policiesLocal public health effortsEndemic COVID-19Public health effortsPublic healthPublic health policyLong-term dataCOVID-19 transmissionHealth effortsMedical preparednessVaccination driveHealth policyVaried interventionsEndemic diseaseSeasonal surgesInterventionInfectionEffective healthcareEndemic pathogensInfection by SARS‐CoV‐2 with alternate frequencies of mRNA vaccine boosting
Townsend J, Hassler H, Dornburg A. Infection by SARS‐CoV‐2 with alternate frequencies of mRNA vaccine boosting. Journal Of Medical Virology 2023, 95: e28461. PMID: 36602045, DOI: 10.1002/jmv.28461.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Anti-spike IgG antibodiesWaning of antibodiesVaccine boostingBooster vaccinationBreakthrough infectionsAntibody levelsIgG antibodiesMRNA vaccinesProbability of infectionInfectionEndemic transmissionIndividual infectionsPredominant variantCOVID-19 pandemicMessenger RNAAntibodiesDisease spreadBNT162b2HospitalizationMorbidityVaccinationWidespread uptakeVaccineMortality
2022
Quarantine and serial testing for variants of SARS-CoV-2 with benefits of vaccination and boosting on consequent control of COVID-19
Wells CR, Pandey A, Gokcebel S, Krieger G, Donoghue AM, Singer BH, Moghadas SM, Galvani AP, Townsend JP. Quarantine and serial testing for variants of SARS-CoV-2 with benefits of vaccination and boosting on consequent control of COVID-19. PNAS Nexus 2022, 1: pgac100. PMID: 35909795, PMCID: PMC9335027, DOI: 10.1093/pnasnexus/pgac100.Peer-Reviewed Original ResearchSARS-CoV-2Serial testingSerial testing strategyHigh population immunityQuarantine durationBenefits of vaccinationSARS-CoV-2 variantsDisease time courseCOVID-19CoV-2 variantsPublic health toolVaccine boostingThird doseVaccination statusVaccination coveragePopulation immunityCoV-2Health toolsDisease control effortsInfected casesLocal transmissionInfectiousness profileVaccinationTime courseImmunity