Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures
Johnsen P, Townsend J, Bøhn T, Simonsen G, Sundsfjord A, Nielsen K. Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures. Journal Of Antimicrobial Chemotherapy 2011, 66: 608-610. PMID: 21217128, PMCID: PMC3037156, DOI: 10.1093/jac/dkq512.Peer-Reviewed Original ResearchConceptsPopulation genetic modelsRelative fitness differencesStrong selectionBacterial fitnessFitness differencesFitness costsSelection coefficientsSelective pressureGlycopeptide-resistant Enterococcus faeciumResistance determinantsBiological fitness costBiological costGenetic modelsFarm environmentGlycopeptide resistance