2011
Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures
Johnsen P, Townsend J, Bøhn T, Simonsen G, Sundsfjord A, Nielsen K. Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures. Journal Of Antimicrobial Chemotherapy 2011, 66: 608-610. PMID: 21217128, PMCID: PMC3037156, DOI: 10.1093/jac/dkq512.Peer-Reviewed Original ResearchConceptsPopulation genetic modelsRelative fitness differencesStrong selectionBacterial fitnessFitness differencesFitness costsSelection coefficientsSelective pressureGlycopeptide-resistant Enterococcus faeciumResistance determinantsBiological fitness costBiological costGenetic modelsFarm environmentGlycopeptide resistance
2004
Monitoring and modeling horizontal gene transfer
Nielsen KM, Townsend JP. Monitoring and modeling horizontal gene transfer. Nature Biotechnology 2004, 22: 1110-1114. PMID: 15340481, DOI: 10.1038/nbt1006.Peer-Reviewed Original ResearchConceptsHorizontal gene transfer eventsPopulation genetic approachesGene transfer eventsStrength of selectionHorizontal gene transferPopulation genetic modelsWild-type bacteriaLarge bacterial populationsHGT hypothesisBacterial generation timesHGT eventsTransgenic plantsGenetic approachesBacterial communitiesBacterial transformantsBacterial populationsPopulation sizeCurrent monitoring effortsGene transferTransfer eventsYears of growthGeneration timeGenetic modelsBacteriaTime of sampling