2016
Effective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting
Van Name MA, Camp AW, Magenheimer EA, Li F, Dziura JD, Montosa A, Patel A, Tamborlane WV. Effective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting. Diabetes Care 2016, 39: 525-531. PMID: 26908915, PMCID: PMC4806769, DOI: 10.2337/dc15-1899.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdolescentAdultAgedBody Mass IndexChoice BehaviorCommunity Health CentersDiabetes Mellitus, Type 2ExerciseFeasibility StudiesFemaleFood PreferencesHispanic or LatinoHumansInsulinLife StyleMiddle AgedPilot ProjectsPrediabetic StateRisk FactorsSocioeconomic FactorsWaist CircumferenceWeight LossYoung AdultConceptsIntensive lifestyle interventionDiabetes Prevention ProgramCommunity health center settingUsual care groupType 2 diabetesHealth center settingHispanic womenILI groupLifestyle interventionCare groupOral glucose tolerance testCenter settingLow-income Hispanic womenWeight lossSimilar baseline weightGlucose tolerance testPercent body fatType of interventionCHC settingsDPP interventionsUsual careBaseline weightWaist circumferenceGlucose excursionsTolerance test
2014
Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, DePourcq F, Kim G, Tamborlane WV. Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care 2014, 37: 317-324. PMID: 24062325, PMCID: PMC3898759, DOI: 10.2337/dc13-1571.Peer-Reviewed Original ResearchConceptsStandard of careClinical careBlood glucoseObese adolescentsObese youthOral glucose tolerance test glucoseIntensive lifestyle modificationDiabetes Prevention ProgramStandard clinical careInsulin sensitivity indexHealthy lifestyle programType 2 diabetesRisk of T2DChildhood obesity epidemicΒ-cell dysfunctionLifestyle modificationControlled TrialsOGTT glucosePrimary outcomeGlucose toleranceInsulin resistanceLifestyle programAnthropometric assessmentEarly abnormalitiesGlucose levels
2012
Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents
Sakharova OV, Lleva RR, Dziura JD, Spollett GR, Howell SK, Beisswenger PJ, Inzucchi SE. Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents. Journal Of Diabetes And Its Complications 2012, 26: 333-338. PMID: 22541894, DOI: 10.1016/j.jdiacomp.2012.03.027.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAgedBlood GlucoseBody WeightCross-Over StudiesDiabetes Mellitus, Type 2FastingFemaleGlycated HemoglobinGlycation End Products, AdvancedHumansHypoglycemic AgentsInsulin GlargineInsulin LisproInsulin, Long-ActingMaleMiddle AgedPostprandial PeriodTreatment FailureTreatment OutcomeConceptsOral anti-hyperglycemic drugsPost-prandial glucoseInsulin strategiesFree fatty acidsType 2Post-prandial glucose metabolismProgressive β-cell dysfunctionType 2 diabetes patientsPost-prandial glucose levelsDaily insulin glargineInitial insulin regimenPrecursor of AGEsSingle-center studyClinical Research CenterLong-term diabetic complicationsAnti-hyperglycemic drugsType 2 diabetesΒ-cell dysfunctionCross-over designInitial insulinInsulin regimenOral agentsInsulin regimensInsulin therapyOAD therapy
2011
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16381-16385. PMID: 21930939, PMCID: PMC3182681, DOI: 10.1073/pnas.1113359108.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHepatic DAG contentInsulin resistanceHepatic insulin resistanceLiver diseaseHepatic steatosisCellular mechanismsHomeostatic model assessmentInsulin resistance indexMarkers of inflammationType 2 diabetesER stress markersLipid dropletsHepatic diacylglycerol contentEndoplasmic reticulum stressActivation of PKCεLiver biopsyNondiabetic individualsHepatocellular lipidsInsulin sensitivityCytoplasmic lipid dropletsDAG contentResistance indexAnimal models
2010
Managing the Space between Visits: A Randomized Trial of Disease Management for Diabetes in a Community Health Center
Anderson DR, Christison-Lagay J, Villagra V, Liu H, Dziura J. Managing the Space between Visits: A Randomized Trial of Disease Management for Diabetes in a Community Health Center. Journal Of General Internal Medicine 2010, 25: 1116-1122. PMID: 20556536, PMCID: PMC2955486, DOI: 10.1007/s11606-010-1419-5.Peer-Reviewed Original ResearchConceptsCommunity health centersUsual careBlood pressureUnderserved patientsHealth centersPhysical activityControl groupDisease management supportTelephonic Disease ManagementDiastolic blood pressureIntake of fruitsBody mass indexType 2 diabetesDisease managementSignificant differencesLow socioeconomic statusDisease management programsSelf-management servicesBehavioral outcome measuresParticipantsAll patientsGlycemic controlPrimary outcomeSuch patientsLDL cholesterolMass index
2009
A multifaceted school-based intervention to reduce risk for type 2 diabetes in at-risk youth
Grey M, Jaser SS, Holl MG, Jefferson V, Dziura J, Northrup V. A multifaceted school-based intervention to reduce risk for type 2 diabetes in at-risk youth. Preventive Medicine 2009, 49: 122-128. PMID: 19643125, PMCID: PMC2753673, DOI: 10.1016/j.ypmed.2009.07.014.Peer-Reviewed Original ResearchConceptsSchool-based interventionsInner-city youthStudentsEducational interventionSkills trainingMinority youthRisk youthCity youthMetabolic riskCoachingHealth coachingYouthType 2 diabetes mellitusType 2 diabetesSchoolsEducationDiabetes mellitusHigh riskDepressive symptomsAnthropometric measuresTrainingInterventionRiskGreater improvementMonthsTranslating the Diabetes Prevention Program to Primary Care
Whittemore R, Melkus G, Wagner J, Dziura J, Northrup V, Grey M. Translating the Diabetes Prevention Program to Primary Care. Nursing Research 2009, 58: 2-12. PMID: 19092550, PMCID: PMC2689783, DOI: 10.1097/nnr.0b013e31818fcef3.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiabetes Mellitus, Type 2FemaleHumansHypercholesterolemiaHypertensionLife StyleMaleMiddle AgedNew EnglandNurse PractitionersNursing Evaluation ResearchNutritional SciencesObesityPatient Education as TopicPatient SatisfactionPilot ProjectsPrimary Health CareProgram EvaluationProspective StudiesSingle-Blind MethodConceptsStandard care participantsType 2 diabetesLifestyle programNurse practitionersHigh-density lipoproteinPrimary careCare participantsLifestyle change programDiabetes Prevention ProgramExercise behaviorMixed-model repeated-measures analysisRisk of diabetesStandard care programmeRepeated-measures analysisLifestyle participantsTreatment goalsCare programPrevention programsClinical settingPsychosocial strategiesDiabetesLow-income sampleWeight lossMotivational interviewingCare
2007
Effects of a Weight Management Program on Body Composition and Metabolic Parameters in Overweight Children: A Randomized Controlled Trial
Savoye M, Shaw M, Dziura J, Tamborlane WV, Rose P, Guandalini C, Goldberg-Gell R, Burgert TS, Cali AM, Weiss R, Caprio S. Effects of a Weight Management Program on Body Composition and Metabolic Parameters in Overweight Children: A Randomized Controlled Trial. JAMA 2007, 297: 2697-2704. PMID: 17595270, DOI: 10.1001/jama.297.24.2697.Peer-Reviewed Original ResearchConceptsWeight management programWeight management groupOverweight childrenMetabolic complicationsInsulin resistanceBody fatBody compositionControl groupArray of comorbiditiesMost overweight childrenSix-month improvementsHomeostasis model assessmentPediatric obesity clinicSerious metabolic complicationWeight management counselingType 2 diabetesMajor health issueFamily-based programsMixed ethnic groupsMonths of studyHOMA-IRObesity clinicOverweight adultsControlled TrialsPediatric obesityInterethnic Differences in Muscle, Liver and Abdominal Fat Partitioning in Obese Adolescents
Liska D, Dufour S, Zern TL, Taksali S, Calí AM, Dziura J, Shulman GI, Pierpont BM, Caprio S. Interethnic Differences in Muscle, Liver and Abdominal Fat Partitioning in Obese Adolescents. PLOS ONE 2007, 2: e569. PMID: 17593968, PMCID: PMC1892806, DOI: 10.1371/journal.pone.0000569.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingLiver fat contentHepatic fat contentInsulin resistanceObese adolescentsAfrican AmericansOral glucose tolerance testingObese Hispanic adolescentsAbdominal fat distributionGlucose tolerance testingType 2 diabetesTotal body fatEthnic differencesClear ethnic differencesVisceral fatInsulin sensitivityFat distributionTolerance testingIMCL levelsMultiethnic cohortObese youthFat contentAbdominal cavityBody fatSoleus muscle
2006
Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents
Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S. Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents. Diabetologia 2006, 49: 571-579. PMID: 16456682, DOI: 10.1007/s00125-005-0109-z.Peer-Reviewed Original ResearchConceptsEarly insulin responseObese childrenInsulin resistanceInsulin clearanceInsulin responseAims/hypothesisThe prevalenceObesity-related insulin resistanceOral glucose loadLower insulin clearanceType 2 diabetesAcute insulin responseGlucose tolerance levelsAltered glucose metabolismSevere insulin resistanceBeta-cell adaptationAfrican American subjectsEthnic groupsHypothesisThe prevalenceGlucose toleranceGlucose loadInsulin sensitivityGlucose metabolismMethodsSeven hundredClearanceHispanic origin
2004
Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S. Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 1096-1101. PMID: 15001593, DOI: 10.1210/jc.2003-031503.Peer-Reviewed Original ResearchConceptsWhole-body insulin sensitivity indexOral glucose tolerance testInsulin sensitivity indexIntramyocellular lipid contentInsulin sensitivityInsulin resistanceObese youthLarge cohortComposite whole body insulin sensitivity indexOral glucose tolerance test parametersSurrogate indexClamp-derived insulin sensitivityImpaired glucose toleranceGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampInsulin sensitivity measurementsGlucose toleranceMetabolic syndromeObese childrenObese populationPoor functionPlasma glucoseTolerance testInsulin response
2003
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance. Science 2003, 300: 1140-1142. PMID: 12750520, PMCID: PMC3004429, DOI: 10.1126/science.1082889.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdolescentAdultAgedAged, 80 and overAgingBlood GlucoseBody Mass IndexFemaleHumansInsulinInsulin ResistanceLiverMaleMiddle AgedMitochondriaMitochondrial DiseasesMuscle, SkeletalNuclear Magnetic Resonance, BiomolecularOxidation-ReductionOxygen ConsumptionPhosphorylationTriglyceridesConceptsInsulin resistanceInsulin-stimulated muscle glucose metabolismType 2 diabetesMuscle glucose metabolismLean body massElderly study participantsAge-associated declineMitochondrial function contributesFat massFat accumulationGlucose metabolismYoung controlsStudy participantsLiver tissueFunction contributesMitochondrial dysfunctionYounger participantsPossible roleMitochondrial oxidativeBody massMagnetic resonance spectroscopyParticipantsDiabetesDysfunctionPathogenesis