Longitudinal Effects of MRI-Measured Hepatic Steatosis on Biomarkers of Glucose Homeostasis and Hepatic Apoptosis in Obese Youth
Kim G, Giannini C, Pierpont B, Feldstein AE, Santoro N, Kursawe R, Shaw M, Duran E, Goldberg R, Dziura J, Caprio S. Longitudinal Effects of MRI-Measured Hepatic Steatosis on Biomarkers of Glucose Homeostasis and Hepatic Apoptosis in Obese Youth. Diabetes Care 2012, 36: 130-136. PMID: 22933439, PMCID: PMC3526202, DOI: 10.2337/dc12-0277.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingWhole-body insulin sensitivityInsulin sensitivityObese youthHepatic steatosisInsulin resistanceHepatocellular apoptosisGlucose homeostasisOral glucose tolerance testHepatic apoptosisAbdominal magnetic resonance imagingCK-18 levelsFatty liver groupGlucose tolerance testHepatic fat contentLiver groupIndependent predictorsFatty liverDisposition indexTolerance testBlood glucoseMetabolic parametersCK-18Multivariate analysisResonance imaging