2023
Bartonella in Norway rats (Rattus norvegicus) from the urban slum environment in Brazil
Zeppelini C, Oliveira D, Kosoy M, Reis M, Ko A, Childs J, Costa F. Bartonella in Norway rats (Rattus norvegicus) from the urban slum environment in Brazil. Anais Da Academia Brasileira De Ciências 2023, 95: e20220809. PMID: 37909607, DOI: 10.1590/0001-3765202320220809.Peer-Reviewed Original Research
2022
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Eyre MT, Souza FN, Carvalho-Pereira T, Nery N, de Oliveira D, Cruz JS, Sacramento GA, Khalil H, Wunder EA, Hacker KP, Hagan JE, Childs JE, Reis MG, Begon M, Diggle PJ, Ko AI, Giorgi E, Costa F. Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil. ELife 2022, 11: e73120. PMID: 36111781, PMCID: PMC9560157, DOI: 10.7554/elife.73120.Peer-Reviewed Original ResearchConceptsInfection riskSignificant global public health burdenCommunity-based cohort studyGlobal public health burdenPublic health burdenAgents of leptospirosisExposure of interestYears of agePublic health interventionsHigh-risk communitiesJoint spatial modellingZoonotic spilloverCohort studyHuman infection riskMale genderSerological evidenceHealth burdenLeptospira infectionLeptospiral infectionInfection rateHealth interventionsEco-epidemiological studiesHealth surveillanceFundação de Amparo à PesquisaOswaldo Cruz FoundationEvaluation of the impact of chemical control on the ecology of Rattus norvegicus of an urban community in Salvador, Brazil
Pertile A, Lustosa R, Carvalho-Pereira T, Pedra G, Panti-May J, Oliveira U, Zeppelini C, Souza F, Oliveira D, Khalil H, Reis M, Childs J, Ko A, Begon M, Costa F. Evaluation of the impact of chemical control on the ecology of Rattus norvegicus of an urban community in Salvador, Brazil. PLOS ONE 2022, 17: e0270568. PMID: 35857771, PMCID: PMC9299319, DOI: 10.1371/journal.pone.0270568.Peer-Reviewed Original ResearchConceptsRodent control programsDemographic variablesSpirochete Leptospira interrogansControl interventionsCommunity settingsR. norvegicusChi-squareControl of zoonosesLeptospira interrogansChemical interventionDemographic characteristicsInterventionIntervention campaignsRodentsSynanthropic rodentsMonthsBody massControl programsControl practicesRattus norvegicusControl campaignsUrban poor communitiesPopulationEnvironmental transmissionAnalysis of variance
2021
Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
Casanovas-Massana A, de Oliveira D, Schneider AG, Begon M, Childs JE, Costa F, Reis MG, Ko AI, Wunder EA. Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis. The Journal Of Infectious Diseases 2021, 225: 130-134. PMID: 34139761, PMCID: PMC8730487, DOI: 10.1093/infdis/jiab323.Peer-Reviewed Original ResearchConceptsPotential environmental pathwaysEnvironmental reservoirsSpillover infectionsEnvironmental pathwaysHuman leptospirosis casesSevere leptospirosisLeptospirosis infectionLeptospirosis casesMolecular epidemiologyGenetic evidencePathogenic LeptospiraLeptospira interrogansInfectionLeptospirosisUrban slumsSpillover pathwaysRat specimensReservoirPathwayUrban communitiesCommunityEpidemiology
2001
Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City.
Comer J, Diaz T, Vlahov D, Monterroso E, Childs J. Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City. American Journal Of Tropical Medicine And Hygiene 2001, 65: 855-60. PMID: 11791987, DOI: 10.4269/ajtmh.2001.65.855.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, BacterialBartonellaBartonella InfectionsCohort StudiesCross ReactionsFemaleFluorescent Antibody Technique, IndirectHIV SeropositivityHumansMaleNew York CityPrevalenceRatsRickettsiaRickettsia InfectionsSubstance Abuse, IntravenousSurveys and QuestionnairesUrban HealthConceptsInjection drug usersDrug usersGroup rickettsiaeSerum samplesIntravenous drug usersCross-adsorption studiesEast HarlemR. akari infectionPrimary etiologic agentTyphus group rickettsiaeFever group rickettsiaeIDU populationHigh prevalenceEtiologic agentNew York CityRickettsia akariBartonella henselaeAntigenTesting panelsRickettsia typhiB. henselaeBartonella quintanaR. rickettsiiRickettsia infectionR. akariPersistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato.
Castro M, Nicholson W, Kramer V, Childs J. Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato. American Journal Of Tropical Medicine And Hygiene 2001, 65: 261-7. PMID: 11693866, DOI: 10.4269/ajtmh.2001.65.261.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialArachnid VectorsBase SequenceBorrelia burgdorferiCaliforniaDisease ReservoirsDNA, BacterialEhrlichiaEhrlichiosisFemaleFluorescent Antibody Technique, IndirectHeat-Shock ProteinsHumansIxodesMaleMicePolymerase Chain ReactionRatsRodent DiseasesSeasonsSeroepidemiologic StudiesSigmodontinaeZoonosesConceptsPolymerase chain reaction testingGroESL heat shock operonPersistent infectionReaction testingRatsE. phagocytophilaLyme diseaseBorrelia burgdorferiMiceSeropositive animalsDusky-footed wood ratsPCRWood ratsSeroreversionSensu latoSeroconversionSeropositiveBiopsySerologySeroreactivityInfectionDiseaseBloodAdult Ixodes pacificus CooleySerumUrban Zoonoses Caused by Bartonella, Coxiella, Ehrlichia, and Rickettsia Species
Comer J, Paddock C, Childs J. Urban Zoonoses Caused by Bartonella, Coxiella, Ehrlichia, and Rickettsia Species. Vector-Borne And Zoonotic Diseases 2001, 1: 91-118. PMID: 12653141, DOI: 10.1089/153036601316977714.Peer-Reviewed Original Research
2000
Experimental evidence of host specificity of Bartonella infection in rodents
Kosoy M, Saito E, Green D, Marston E, Jones D, Childs J. Experimental evidence of host specificity of Bartonella infection in rodents. Comparative Immunology Microbiology And Infectious Diseases 2000, 23: 221-238. PMID: 11038125, DOI: 10.1016/s0147-9571(99)00075-2.Peer-Reviewed Original ResearchPrevalence of Antibody to Hepatitis E Virus among Rodents in the United States
Favorov M, Kosoy M, Tsarev S, Childs J, Margolis H. Prevalence of Antibody to Hepatitis E Virus among Rodents in the United States. The Journal Of Infectious Diseases 2000, 181: 449-455. PMID: 10669325, DOI: 10.1086/315273.Peer-Reviewed Original Research
1999
Dusky-Footed Wood Rats (Neotoma fuscipes) as Reservoirs of Granulocytic Ehrlichiae (Rickettsiales: Ehrlichieae) in Northern California
Nicholson W, Castro M, Kramer V, Sumner J, Childs J. Dusky-Footed Wood Rats (Neotoma fuscipes) as Reservoirs of Granulocytic Ehrlichiae (Rickettsiales: Ehrlichieae) in Northern California. Journal Of Clinical Microbiology 1999, 37: 3323-3327. PMID: 10488199, PMCID: PMC85556, DOI: 10.1128/jcm.37.10.3323-3327.1999.Peer-Reviewed Original ResearchConceptsBlood samplesBlood specimensDusky-footed wood ratsConcurrent high prevalenceSeronegative blood samplesHuman granulocytic ehrlichiosisGroESL heat shock operonGranulocytic ehrlichiaePCR-positive animalsPCR positivityHigh prevalencePCR-positive ticksSeropositive specimensRat blood samplesRatsGranulocytic ehrlichiosisEhrlichial DNAPacificus adultsEhrlichia equiEhrlichial agentsMicePCR assaysAdultsWood ratsRodentsRats of the Genus Rattus are Reservoir Hosts for Pathogenic Bartonella Species: An Old World Origin for a New World Disease?
Ellis B, Regnery R, Beati L, Bacellar F, Rood M, Glass G, Marston E, Ksiazek T, Jones D, Childs J. Rats of the Genus Rattus are Reservoir Hosts for Pathogenic Bartonella Species: An Old World Origin for a New World Disease? The Journal Of Infectious Diseases 1999, 180: 220-224. PMID: 10353885, DOI: 10.1086/314824.Peer-Reviewed Original Research
1998
Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida.
Glass G, Livingstone W, Mills J, Hlady W, Fine J, Biggler W, Coke T, Frazier D, Atherley S, Rollin P, Ksiazek T, Peters C, Childs J. Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida. American Journal Of Tropical Medicine And Hygiene 1998, 59: 699-703. PMID: 9840584, DOI: 10.4269/ajtmh.1998.59.699.Peer-Reviewed Original ResearchEpidemiology of Rodent Bites and Prediction of Rat Infestation in New York City
Childs J, McLafferty S, Sadek R, Miller G, Khan A, DuPree E, Advani R, Mills J, Glass G. Epidemiology of Rodent Bites and Prediction of Rat Infestation in New York City. American Journal Of Epidemiology 1998, 148: 78-87. PMID: 9663407, DOI: 10.1093/oxfordjournals.aje.a009563.Peer-Reviewed Original Research
1997
Distribution, diversity, and host specificity of Bartonella in rodents from the Southeastern United States.
Kosoy M, Regnery R, Tzianabos T, Marston E, Jones D, Green D, Maupin G, Olson J, Childs J. Distribution, diversity, and host specificity of Bartonella in rodents from the Southeastern United States. American Journal Of Tropical Medicine And Hygiene 1997, 57: 578-88. PMID: 9392599, DOI: 10.4269/ajtmh.1997.57.578.Peer-Reviewed Original ResearchConceptsPhylogenetic groupsHost specificityDistinct phylogenetic groupsCitrate synthase geneSpecies of PeromyscusMajor biotic communitiesSpecies of rodentsSoutheastern United StatesDegree of homologyRodent communitiesSynthase geneWild-caught rodentsBiotic communitiesSequence homologyBartonella isolatesSequence analysisBartonellaSpeciesHomologyGenotypic groupsGenotypic variantsGeographic sitesSingle siteRodentsGenes
1995
Isolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida
Rollin P, Ksiazek T, Elliott L, Ravkov E, Martin M, Morzunov S, Livingstone W, Monroe M, Glass G, Ruo S, Khan A, Childs J, Nichol S, Peters C. Isolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida. Journal Of Medical Virology 1995, 46: 35-39. PMID: 7623004, DOI: 10.1002/jmv.1890460108.Peer-Reviewed Original ResearchConceptsBlack Creek Canal virusReverse transcriptase-polymerase chain reaction assaysNew hantavirusCotton ratsTranscriptase-polymerase chain reaction assaysVero E6 cellsHantavirus pulmonary syndrome casesVirologic studiesChain reaction assaysHantavirus antigensHigh seroprevalenceSyndrome casesE6 cellsSpleen homogenatesRT-PCRReaction assaysDirect RT-PCRVirusSerologic relationshipHantavirusesRatsRodentsSigmodon hispidusDade CountySeroprevalence
1992
Risk factors associated with antibodies to leptospires in inner-city residents of Baltimore: a protective role for cats.
Childs J, Schwartz B, Ksiazek T, Graham R, LeDuc J, Glass G. Risk factors associated with antibodies to leptospires in inner-city residents of Baltimore: a protective role for cats. American Journal Of Public Health 1992, 82: 597-599. PMID: 1546785, PMCID: PMC1694107, DOI: 10.2105/ajph.82.4.597.Peer-Reviewed Original Research
1991
Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population.
Childs J, Glass G, Ksiazek T, Rossi C, Oro J, Leduc J. Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population. American Journal Of Tropical Medicine And Hygiene 1991, 44: 117-21. PMID: 1672798, DOI: 10.4269/ajtmh.1991.44.117.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusSeoul virusRodent-borne virusesHuman-rodent contactHistory of travelInner-city populationDisease clinicRodent exposureLymphocytic choriomeningitisAntibody prevalenceNeutralization testSerological testsAntibodiesVirusHigh rateInfectionRatsMore exposureExposureQuestionnaire responsesChoriomeningitisClinicPrevalenceMicePersons
1989
EFFECTS OF HANTAVIRAL INFECTION ON SURVIVAL, GROWTH AND FERTILITY IN WILD RAT (RATTUS NORVEGICUS) POPULATIONS OF BALTIMORE, MARYLAND
Childs J, Glass G, Korch G, LeDuc J. EFFECTS OF HANTAVIRAL INFECTION ON SURVIVAL, GROWTH AND FERTILITY IN WILD RAT (RATTUS NORVEGICUS) POPULATIONS OF BALTIMORE, MARYLAND. Journal Of Wildlife Diseases 1989, 25: 469-476. PMID: 2572705, DOI: 10.7589/0090-3558-25.4.469.Peer-Reviewed Original Research
1988
Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus)
Glass G, Childs J, Korch G, LeDuc J. Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiology And Infection 1988, 101: 459-472. PMID: 3141203, PMCID: PMC2249393, DOI: 10.1017/s0950268800054418.Peer-Reviewed Original ResearchConceptsSerological statusProspective sero-epidemiological studyIncidence of seroconversionSero-epidemiological studiesPresence of woundsHantaviral infectionsUnwounded animalsSignificant associationSeroconversionRat ageEnvironmental exposuresNorway ratsLongitudinal studyRatsInfectionWild Norway ratsWild ratsAssociationAnimalsSeroprevalenceIncidenceEVIDENCE OF HUMAN INFECTION WITH A RAT-ASSOCIATED HANTAVIRUS IN BALTIMORE, MARYLAND
CHILDS J, GLASS G, KORCH G, ARTHUR R, SHAH K, GLASSER D, ROSSI C, LEDUC J. EVIDENCE OF HUMAN INFECTION WITH A RAT-ASSOCIATED HANTAVIRUS IN BALTIMORE, MARYLAND. American Journal Of Epidemiology 1988, 127: 875-878. PMID: 3128102, DOI: 10.1093/oxfordjournals.aje.a114871.Peer-Reviewed Original Research