2021
Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents
Fisher B, Zaoutis T, Xiao R, Wattier R, Castagnola E, Pana Z, Fullenkamp A, Boge C, Ross R, Yildirim I, Palazzi D, Danziger-Isakov L, Vora S, Arrieta A, Yin D, Avilés-Robles M, Sharma T, Tribble A, Maron G, Berman D, Green M, Sung L, Romero J, Hauger S, Roilides E, Belani K, Nolt D, Soler-Palacin P, López-Medina E, Muller W, Halasa N, Dulek D, Bin Hussain I, Pong A, Hoffman J, Rajan S, Gonzalez B, Hanisch B, Aftandilian C, Carlesse F, Abzug M, Huppler A, Salvatore C, Ardura M, Chakrabarti A, Santolaya M, Localio A, Steinbach W. Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents. Journal Of The Pediatric Infectious Diseases Society 2021, 10: 994-1003. PMID: 34374424, DOI: 10.1093/jpids/piab024.Peer-Reviewed Original ResearchAmphotericin B formulationsInvasive candidiasisAmphotericin B groupRisk differenceExposure groupB formulationsMultinational observational cohort studyCommon invasive fungal diseaseCrude failure rateData review committeeObservational cohort studyB groupInvasive fungal diseaseMantel-Haenszel analysisCohort studyPrimary outcomePrimary exposureFailure rateComparative effectivenessCandidiasisTherapyEffectiveness dataEchinocandinsReview CommitteeChildren
2020
Recognition and Outcomes of Pneumococcal Meningitis in 2 Tertiary Pediatric Hospitals Since the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine
Stevens JP, Lively A, Jerris R, Yildirim I, Lantis P. Recognition and Outcomes of Pneumococcal Meningitis in 2 Tertiary Pediatric Hospitals Since the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine. Pediatric Emergency Care 2020, 38: e354-e359. PMID: 33181795, DOI: 10.1097/pec.0000000000002288.Peer-Reviewed Original ResearchConceptsPneumococcal conjugate vaccineLumbar puncturePneumococcal meningitisConjugate vaccineMeningeal signsLow suspicionMental statusPositive cerebrospinal fluid culturesLonger hospital lengthStreptococcus pneumoniae meningitisCerebrospinal fluid culturesCranial nerve palsyHours of admissionTertiary pediatric hospitalPoor clinical outcomeTertiary healthcare systemPneumococcal meningitis casesPneumococcal immunizationPneumoniae meningitisHospital lengthNerve palsyPrimary outcomeAntibiotic administrationClinical outcomesPediatric hospital
2018
2280. Antibiotic Exposure Does Not Impact Serological Responses to Rotavirus Vaccination
Anderson E, Lopman B, Yi J, Yildirim I, Creech C, El-Khorazaty J, Shane A, Edwards K. 2280. Antibiotic Exposure Does Not Impact Serological Responses to Rotavirus Vaccination. Open Forum Infectious Diseases 2018, 5: s675-s676. PMCID: PMC6255677, DOI: 10.1093/ofid/ofy210.1933.Peer-Reviewed Original ResearchGeometric mean titersAntibiotic exposureLogistic regression modelsRV vaccinesMultivariable logistic regression modelConcomitant antibiotic useRV immunizationLast doseVaccine doseVaccine groupImmunized childrenPrimary outcomeRotavirus immunizationAntibiotic administrationMean titersRegression modelsVaccine dosesSerological responseTreatment allocationAntibiotic useInclusion criteriaVaccine studiesImmune responseTreatment groupsSeroresponses