2017
On Joint Estimation of Gaussian Graphical Models for Spatial and Temporal Data
Lin Z, Wang T, Yang C, Zhao H. On Joint Estimation of Gaussian Graphical Models for Spatial and Temporal Data. Biometrics 2017, 73: 769-779. PMID: 28099997, PMCID: PMC5515703, DOI: 10.1111/biom.12650.Peer-Reviewed Original ResearchConceptsGaussian graphical modelsTemporal dataGraphical modelsComplex data structuresJoint estimationMarkov random field modelRandom field modelParallel computingSelection consistencyData structureStatistical inferenceNeighborhood selection methodTemporal dependenciesEfficient algorithmIndividual networksMultiple groupsSpatial dataModel convergesNetwork estimationField modelSelection methodNetworkPosterior probabilitySimulation studyImproved estimationGraphical model selection with latent variables
Wu C, Zhao H, Fang H, Deng M. Graphical model selection with latent variables. Electronic Journal Of Statistics 2017, 11: 3485-3521. DOI: 10.1214/17-ejs1331.Peer-Reviewed Original ResearchGraphical model selectionModel selection consistencyEfficient ADMM algorithmSparse precision matrixGraphical modelsGaussian graphical modelsGenetical genomics dataSelection consistencyPenalized estimationStatistical inferencePrecision matrixLatent variablesParameter estimationTheoretical propertiesIdentifiability conditionsADMM algorithmModel selectionSimulation studyConditional dependenceEstimationTrace lossSuperior performanceEstimatorGraphVariables
2016
On an additive partial correlation operator and nonparametric estimation of graphical models
Lee KY, Li B, Zhao H. On an additive partial correlation operator and nonparametric estimation of graphical models. Biometrika 2016, 103: 513-530. PMID: 29422689, PMCID: PMC5793672, DOI: 10.1093/biomet/asw028.Peer-Reviewed Original Research
2014
GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
Chung D, Yang C, Li C, Gelernter J, Zhao H. GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation. PLOS Genetics 2014, 10: e1004787. PMID: 25393678, PMCID: PMC4230845, DOI: 10.1371/journal.pgen.1004787.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesFunctional annotationGWAS datasetsAnnotation informationStatistical approachMultiple GWAS datasetsGenome-wide markersPowerful statistical methodsSingle-phenotype analysisCentral nervous system genesRisk variantsNervous system genesGenotype-Tissue Expression (GTEx) databaseComplex diseasesGWAS data setsSignificant pleiotropic effectsCommon risk basisDifferent complex diseasesDNase-seq dataCell linesStatistical inferenceGenetic architectureGWAS hitsGWAS resultsNovel statistical approach
2011
Bayesian hierarchical modeling for signaling pathway inference from single cell interventional data
Luo R, Zhao H. Bayesian hierarchical modeling for signaling pathway inference from single cell interventional data. The Annals Of Applied Statistics 2011, 5: 725-745. PMID: 22162986, PMCID: PMC3233205, DOI: 10.1214/10-aoas425.Peer-Reviewed Original ResearchMarkov chain Monte CarloReal data analysisBayesian hierarchical modeling frameworkHierarchical modelingHierarchical modeling frameworkBayesian hierarchical modelingStatistical inferencePosterior distributionMonte CarloNetwork sparsitySimulation studyIntrinsic noiseModeling frameworkMeasurement errorInterventional dataInferenceMultiple protein activitiesPathway inferenceCarloModelingInterventional experimentsSuch dataSparsityData analysisNoiseIncorporating Biological Pathways via a Markov Random Field Model in Genome-Wide Association Studies
Chen M, Cho J, Zhao H. Incorporating Biological Pathways via a Markov Random Field Model in Genome-Wide Association Studies. PLOS Genetics 2011, 7: e1001353. PMID: 21490723, PMCID: PMC3072362, DOI: 10.1371/journal.pgen.1001353.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesBiological pathwaysSingle gene-based methodsMarkov random field modelGene-based methodsPrior biological knowledgeRandom field modelGWAS analysisAssociation signalsMultiple genesPathway topologyGene associationsAssociation analysisGenesBiological knowledgeField modelGenetic variantsSpecific pathwaysReal data examplePathwayStatistical inferenceConditional modes algorithmExchangeable setRegression form