Integrative Tissue-Specific Functional Annotations in the Human Genome Provide Novel Insights on Many Complex Traits and Improve Signal Prioritization in Genome Wide Association Studies
Lu Q, Powles RL, Wang Q, He BJ, Zhao H. Integrative Tissue-Specific Functional Annotations in the Human Genome Provide Novel Insights on Many Complex Traits and Improve Signal Prioritization in Genome Wide Association Studies. PLOS Genetics 2016, 12: e1005947. PMID: 27058395, PMCID: PMC4825932, DOI: 10.1371/journal.pgen.1005947.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGWAS signalsComplex traitsFunctional annotationAssociation studiesHuman complex traitsFunctional regionsNon-coding regionsGWAS p-valuesWide association studyNovel biological insightsRelevant tissue typesEpigenetic annotationsGenomic functionsRegulatory machineryTransposable elementsHuman genomeGenoSkylineRisk lociBiological insightsIntegrative analysisGenetic studiesRegulatory miRNAPrioritization performanceSpecific annotations