Featured Publications
Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation
Song S, Jiang W, Zhang Y, Hou L, Zhao H. Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation. American Journal Of Human Genetics 2022, 109: 802-811. PMID: 35421325, PMCID: PMC9118121, DOI: 10.1016/j.ajhg.2022.03.013.Peer-Reviewed Original ResearchConceptsLinkage disequilibrium score regressionComplex traitsSingle nucleotide polymorphismsSNP heritabilityGenome-wide association studiesDisequilibrium score regressionHigh-throughput technologiesHeritable phenotypesAssociation studiesGenetic studiesCryptic relatednessLD informationScore regressionHeritabilityGenetic contributionHeritability estimationPopulation stratificationDisease mechanismsTraitsLD matrixOnly summary statisticsUK BiobankPolygenicitySummary statisticsRelatedness
2022
Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics
Hu X, Zhao J, Lin Z, Wang Y, Peng H, Zhao H, Wan X, Yang C. Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2106858119. PMID: 35787050, PMCID: PMC9282238, DOI: 10.1073/pnas.2106858119.Peer-Reviewed Original Research
2000
Family-based association studies
Zhao H. Family-based association studies. Statistical Methods In Medical Research 2000, 9: 563-587. PMID: 11308071, DOI: 10.1177/096228020000900604.Peer-Reviewed Original ResearchConceptsFamily-based association designComplex disease genesDisease genesBias due to population stratificationDetect gene-environment interactionsAssociation studiesLinkage studiesIncomplete parental genotypesPresence of population substructureAssociation designFamily-based association studyStudy quantitative traitsTraditional linkage studiesMendelian disease genesBiallelic genetic markerCase-control association studyGene-environment interactionsHuman Genome ProjectCase-control studyMultiallelic markersPopulation substructurePopulation stratificationPedigree structureGenome ProjectPositional cloningTransmission/Disequilibrium Tests Using Multiple Tightly Linked Markers
Zhao H, Zhang S, Merikangas K, Trixler M, Wildenauer D, Sun F, Kidd K. Transmission/Disequilibrium Tests Using Multiple Tightly Linked Markers. American Journal Of Human Genetics 2000, 67: 936-946. PMID: 10968775, PMCID: PMC1287895, DOI: 10.1086/303073.Peer-Reviewed Original Research