Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial
Barnhart KT, Sammel MD, Stephenson M, Robins J, Hansen KR, Youssef WA, Santoro N, Eisenberg E, Zhang H, Network F. Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial. Contemporary Clinical Trials 2018, 73: 145-151. PMID: 30243810, PMCID: PMC6231403, DOI: 10.1016/j.cct.2018.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAbortifacient Agents, NonsteroidalAbortion, SpontaneousChorionic GonadotropinDiagnosis, DifferentialDilatation and CurettageFemaleHumansMethotrexatePregnancyPregnancy, EctopicUltrasonographyWatchful WaitingConceptsOutcome measuresHuman chorionic gonadotropin concentrationRuptured ectopic pregnancyPositive pregnancy testSecondary outcome measuresExtra-uterine pregnancyInitial management strategyPrimary outcome measureChorionic gonadotropin concentrationsPatient satisfaction outcomesInitial management planAcademic medical centerEvidence-based managementAdditional ultrasonographyPersistent PULEctopic pregnancyExpectant managementAdverse eventsClinical resolutionEmpiric useGonadotropin concentrationsTransvaginal ultrasonographyTreatment complicationsTreatment armsUterine evacuation