2020
Live birth after a freeze-only strategy versus fresh embryo transfer in three randomized trials considering progesterone concentration
Yu Y, Zhao S, Li Y, Niu Y, Wei D, Zhang S, Chen ZJ, Zhang H, Legro RS. Live birth after a freeze-only strategy versus fresh embryo transfer in three randomized trials considering progesterone concentration. Reproductive BioMedicine Online 2020, 41: 395-401. PMID: 32600942, DOI: 10.1016/j.rbmo.2020.04.021.Peer-Reviewed Original ResearchConceptsLive birth rateFresh embryo transferProgesterone concentrationsEmbryo transferOvulatory womenRandomized trialsBirth rateHuman chorionic gonadotrophin (HCG) administrationFresh embryo transfer groupCleavage-stage embryo transferFreeze-only strategyHigh ovarian responseInitial embryo transferPolycystic ovary syndromeChorionic gonadotrophin administrationEmbryo transfer groupFrozen embryo transferSingle blastocyst transferBetween-group differencesClinical pregnancyGonadotrophin administrationHCG administrationOvarian responseOvary syndromePrimary outcome
2019
Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial
Wei D, Liu J, Sun Y, Shi Y, Zhang B, Liu J, Tan J, Liang X, Cao Y, Wang Z, Qin Y, Zhao H, Zhou Y, Ren H, Hao G, Ling X, Zhao J, Zhang Y, Qi X, Zhang L, Deng X, Chen X, Zhu Y, Wang X, Tian L, Lv Q, Ma X, Zhang H, Legro R, Chen Z. Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial. The Lancet 2019, 393: 1310-1318. PMID: 30827784, DOI: 10.1016/s0140-6736(18)32843-5.Peer-Reviewed Original ResearchConceptsFrozen single blastocyst transferFresh single blastocyst transferSingle blastocyst transferElective single embryo transferRisk of pre-eclampsiaFrozen blastocyst transferBlastocyst transferLivebirth rateSevere ovarian hyperstimulation syndromePre-eclampsiaOvulatory womenPregnancy rateEmbryo transferOvarian hyperstimulation syndromeAcademic fertility centreFrozen-thawed single blastocyst transferHigher risk of pre-eclampsiaIn vitro fertilisationIncreased risk of pre-eclampsiaFrozen embryo transferExtended embryo cultureSingle embryo transferFertility centreHyperstimulation syndromeLower pregnancy rate
2018
The Effect of Supraphysiological Estradiol on Pregnancy Outcomes Differs Between Women With PCOS and Ovulatory Women
Wei D, Yu Y, Sun M, Shi Y, Sun Y, Deng X, Li J, Wang Z, Zhao S, Zhang H, Legro RS, Chen ZJ. The Effect of Supraphysiological Estradiol on Pregnancy Outcomes Differs Between Women With PCOS and Ovulatory Women. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2735-2742. PMID: 29718297, DOI: 10.1210/jc.2018-00613.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeFrozen embryo transferFresh embryo transferLive birth rateOvulatory womenOvarian stimulationEmbryo transferSupraphysiological estradiolPregnancy outcomesEstradiol levelsBirth ratePeak estradiol levelsMulticenter Randomized TrialSimilar study designPCOS womenOvary syndromeOvarian responsePrimary outcomeRandomized trialsEstradiol exposureLive birthsMAIN OUTCOMEEmbryo implantationPg/Secondary analysisTransfer of Fresh versus Frozen Embryos in Ovulatory Women
Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro R, Chen Z. Transfer of Fresh versus Frozen Embryos in Ovulatory Women. New England Journal Of Medicine 2018, 378: 126-136. PMID: 29320646, DOI: 10.1056/nejmoa1705334.Peer-Reviewed Original ResearchConceptsFresh embryo transferFrozen embryo transferLive birth rateOvarian hyperstimulation syndromeHyperstimulation syndromeElective frozen embryo transferOvulatory womenFrozen-embryo groupFresh embryo groupIn vitro fertilization cyclesHigher live birth ratesPolycystic ovary syndromeRate of implantsCleavage-stage embryosOverall pregnancy lossAnovulatory womenNeonatal complicationsClinical pregnancyOngoing pregnancyFrozen embryosEmbryo cryopreservationBetween-group differencesEmbryo transferLive birthsFertilization cycles
2016
Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome
Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, Yang J, Liu J, Wei D, Weng N, Tian L, Hao C, Yang D, Zhou F, Shi J, Xu Y, Li J, Yan J, Qin Y, Zhao H, Zhang H, Legro RS. Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2016, 375: 523-533. PMID: 27509101, DOI: 10.1056/nejmoa1513873.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvarian hyperstimulation syndromeFresh embryo transferFrozen embryo transferFrozen-embryo transferOvary syndromeHyperstimulation syndromeLive birthsInfertile womenRate ratioFrozen embryosSignificant between-group differencesFresh embryo groupFirst IVF cycleLive birth rateFirst embryo transferBetween-group differencesNeonatal complicationsIVF cyclesPregnancy complicationsMulticenter trialPrimary outcomeNeonatal deathPregnancy lossHigh risk
2014
Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trial
Shi Y, Wei D, Liang X, Sun Y, Liu J, Cao Y, Zhang B, Legro RS, Zhang H, Chen ZJ. Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trial. Trials 2014, 15: 154. PMID: 24885793, PMCID: PMC4022358, DOI: 10.1186/1745-6215-15-154.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferElective embryo cryopreservationFresh embryo transferLive birth rateEmbryo transferPCOS patientsPregnancy complicationsOocyte retrievalClinical trialsEmbryo cryopreservationMethods/designThis studyInfertile PCOS patientsClinical pregnancy ratePolycystic ovary syndromeFrozen embryo transferIntracytoplasmic sperm injectionBirth rateOvary syndromePregnancy outcomesPrimary outcomeAbnormal implantationPregnancy lossParallel groupPregnancy rateGroup B