2008
LOT: a tool for linkage analysis of ordinal traits for pedigree data
Zhang M, Feng R, Chen X, Hu B, Zhang H. LOT: a tool for linkage analysis of ordinal traits for pedigree data. Bioinformatics 2008, 24: 1737-1739. PMID: 18535081, PMCID: PMC2566542, DOI: 10.1093/bioinformatics/btn258.Peer-Reviewed Original Research
2007
A genomic imprinting test for ordinal traits in pedigree data
Feng R, Zhang H. A genomic imprinting test for ordinal traits in pedigree data. Genetic Epidemiology 2007, 32: 132-142. PMID: 17922481, DOI: 10.1002/gepi.20270.Peer-Reviewed Original ResearchConceptsComplex genetic basisOrdinal traitsIdentical nucleotide sequencesGenomic imprintingNumerous common diseasesNovel lociNucleotide sequenceComplex inheritanceGenetic basisChromosome 3Non-genetic covariatesHuman disordersLinkage analysisHuman diseasesGenetics of AlcoholismChromosome 18Continuous traitsTraitsPedigree dataBinary traitsOrigin effectsImprinting testLociStrong signalImprintingA score test for linkage analysis of ordinal traits based on IBD sharing
Feng R, Zhang H. A score test for linkage analysis of ordinal traits based on IBD sharing. Biostatistics 2007, 9: 114-127. PMID: 17519391, DOI: 10.1093/biostatistics/kxm016.Peer-Reviewed Original Research
2006
Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies
Zhang H, Wang X, Ye Y. Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies. Genetics 2006, 172: 693-699. PMID: 16219774, PMCID: PMC1456175, DOI: 10.1534/genetics.105.049122.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsQuantitative traitsOrdinal traitsTraditional linkage studiesGenomewide association analysisAssociation of genesDetection of genesGametic disequilibriumLoci existAssociation studiesAssociation analysisGenesLinkage disequilibriumTraitsComplex diseasesLinkage studiesGrowth-associated protein 43Protein 43DisequilibriumPolymorphismFamilyMarkersNuclear families
2004
Linkage analysis of ordinal traits for pedigree data
Feng R, Leckman JF, Zhang H. Linkage analysis of ordinal traits for pedigree data. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 16739-16744. PMID: 15548606, PMCID: PMC534720, DOI: 10.1073/pnas.0404623101.Peer-Reviewed Original ResearchConceptsLinkage analysisOrdinal traitsTourette Syndrome Association International ConsortiumLinkage analysis methodsQuantitative traitsEvidence of linkageGenome scanLinkage scanHuman diseasesAllele sharingTraitsPedigree dataInheritance patternDichotomous traitsSignificant allele sharingPhenotypeProportional odds logistic modelGENEHUNTERGenesGeneticsMarkersInternational Consortium
2003
A Latent Variable Model of Segregation Analysis for Ordinal Traits
Zhang H, Feng R, Zhu H. A Latent Variable Model of Segregation Analysis for Ordinal Traits. Journal Of The American Statistical Association 2003, 98: 1023-1034. DOI: 10.1198/016214503000000981.Peer-Reviewed Original ResearchDichotomous traitsLatent variable modelsAsymptotic theoryModel of segregation analysisFamilial transmission of alcoholismGene-environment interactionsAssessed familial aggregationConduct simulation studiesGenetic epidemiologySegregation analysisTransmission of alcoholismHealth conditionsOrdinal traitsFamilial aggregationBinary traitsVariable modelComplex genetic basisInheritance of diseaseStatistical inferenceEM algorithmEnvironmental factorsSimulation studyPsychiatric disordersGene componentsAlcohol abuse