2023
Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity
Vitek W, Sun F, Cardozo E, Hoeger K, Hansen K, Santoro N, Zhang H, Legro R. Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity. F&S Reports 2023, 4: 308-312. PMID: 37719091, PMCID: PMC10504528, DOI: 10.1016/j.xfre.2023.06.004.Peer-Reviewed Original ResearchLive birth rateSteps/dayPhysical activityInfertility trialsLifestyle modificationUnexplained infertilityObese womenBirth rateClomiphene citrate treatmentUS fertility centersClinical pregnancy rateLifestyle modification programTime of enrollmentModerate physical activityPhysical activity goalsMiscarriage rateFertility centerIntrauterine inseminationFitbit activity trackerPregnancy rateSecondary analysisCitrate treatmentActivity goalsModification programWomen
2020
OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial
Legro R, Hansen K, Diamond M, Steiner A, Mersereau J, Sarwer D, Kris-Etherton P, Wild R, Krawetz S, Hoeger K, Usadi R, Johnstone E, Hao H, Eisenberg E, Santoro N, Zhang H. OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial. Journal Of The Endocrine Society 2020, 4: or11-04. PMCID: PMC7209215, DOI: 10.1210/jendso/bvaa046.2149.Peer-Reviewed Original ResearchStandard lifestyle modificationBetter birth outcomesUnexplained infertilityLive birthsObese womenBirth outcomesPregnancy lossLifestyle modificationLifestyle interventionWeight lossPhysical activityIL groupLow perinatal morbidityMajor pregnancy complicationsPreconception lifestyle interventionStandard lifestyle interventionGI side effectsKey secondary outcomesMulticenter Randomized TrialUse of orlistatMajor congenital anomaliesModerate weight lossPregnancy complication rateEarly pregnancy lossGestational DM
2016
Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS
Legro RS, Dodson WC, Kunselman AR, Stetter CM, Kris-Etherton PM, Williams NI, Gnatuk CL, Estes SJ, Allison KC, Sarwer DB, Diamond MP, Schlaff WD, Casson PR, Christman GM, Barnhart KT, Bates GW, Usadi R, Lucidi S, Baker V, Zhang H, Eisenberg E, Coutifaris C, Dokras A. Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 2658-2666. PMID: 27172435, PMCID: PMC4929837, DOI: 10.1210/jc.2016-1659.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-Obesity AgentsBehavior TherapyClomipheneCombined Modality TherapyContraceptives, Oral, HormonalFemaleFertility Agents, FemaleHumansInfertility, FemaleLife StyleObesityPolycystic Ovary SyndromePreconception CarePregnancyPregnancy RateReproductive Techniques, AssistedTime FactorsWeight LossYoung AdultConceptsPolycystic ovary syndromeImmediate treatmentLifestyle modificationObese womenOral contraceptivesInfertility treatmentPolycystic Ovary Syndrome trialCumulative live birth rateOvulation rateWeight lossContinuous oral contraceptivesCumulative ovulation rateCycles of clomipheneOral contraceptive pretreatmentPreconception weight lossLive birth rateOverweight/obeseConcurrent clinical trialsYears of ageBirth rateImproved ovulationPPCOS IIPreconception treatmentClomiphene citrateII trial
2015
Impact of Male and Female Weight, Smoking, and Intercourse Frequency on Live Birth in Women With Polycystic Ovary Syndrome
Polotsky AJ, Allshouse AA, Casson PR, Coutifaris C, Diamond MP, Christman GM, Schlaff WD, Alvero R, Trussell JC, Krawetz SA, Santoro N, Eisenberg E, Zhang H, Legro RS. Impact of Male and Female Weight, Smoking, and Intercourse Frequency on Live Birth in Women With Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: 2405-2412. PMID: 25856211, PMCID: PMC4454812, DOI: 10.1210/jc.2015-1178.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeBody mass indexFemale body mass indexMale body mass indexLive birthsOvary syndromeFertility treatment successSexual intercourse attemptsLower chanceNormal semen parametersClomiphene citrateIntercourse attemptsII trialObese menObese womenInfertile womenMale obesityMass indexRegular intercourseProspective dataMale factorTreatment successMale smokingLarge cohortIntercourse frequency