2024
Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine
Hu J, Wang S, Zhang H. Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine. ICSA Book Series In Statistics 2024, 423-451. DOI: 10.1007/978-3-031-50690-1_17.Peer-Reviewed Original ResearchAssociation studiesGenetic association studiesPrecision medicineTests of associationHeterogeneous drug responsesDisease risk predictionVariant identificationSignal variantsControl of type I errorDisease riskDrug responseGenomic profilingType I errorRisk predictionGenetic biomarkersVariantsPharmaceutical interventionsMarginal testsAssociation methodAssociationMedicineInterventionIdentificationReplicationDisease
2012
Large Scale Association Analysis for Drug Addiction: Results from SNP to Gene
Guo X, Liu Z, Wang X, Zhang H. Large Scale Association Analysis for Drug Addiction: Results from SNP to Gene. The Scientific World JOURNAL 2012, 2012: 939584. PMID: 23365539, PMCID: PMC3543790, DOI: 10.1100/2012/939584.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesAssociation analysisGene-based association analysisLarge-scale association analysisSingle nucleotide polymorphism dataWide association studyComplex diseasesGene-based analysisGene-based methodsNucleotide polymorphism dataGenetic association studiesPolymorphism dataGene findingGenetic variantsIndividual SNPsStudy of AddictionSNPsGenetic etiologyGenesComprehensive analysisGeneticsVariants
2011
A LASSO-based approach to analyzing rare variants in genetic association studies
Brennan JS, He Y, Calixte R, Nyirabahizi E, Jiang Y, Zhang H. A LASSO-based approach to analyzing rare variants in genetic association studies. BMC Proceedings 2011, 5: s100. PMID: 22373373, PMCID: PMC3287823, DOI: 10.1186/1753-6561-5-s9-s100.Peer-Reviewed Original Research
2009
Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forests
Wang M, Chen X, Zhang M, Zhu W, Cho K, Zhang H. Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forests. BMC Proceedings 2009, 3: s69. PMID: 20018063, PMCID: PMC2795970, DOI: 10.1186/1753-6561-3-s7-s69.Peer-Reviewed Original ResearchSignificant single nucleotide polymorphismsGenome-wide dataGenetic Analysis Workshop 16 Problem 1 dataGenes/SNPsSNP markersSignificant SNPsSingle nucleotide polymorphismsGenetic association studiesWhole genomeChromosome 6Association studiesRheumatoid arthritis statusAntigen geneTraitsSNPsForestHLA-DRAArray experimentsGenomeMarkersHuman leukocyte antigen (HLA) genesGenesFurther analysisIndividual markersHigh levels