2018
A univariate perspective of multivariate genome‐wide association analysis
Guo X, Zhu J, Fan Q, He M, Wang X, Zhang H. A univariate perspective of multivariate genome‐wide association analysis. Genetic Epidemiology 2018, 42: 470-479. PMID: 29781551, DOI: 10.1002/gepi.22128.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMultivariate genome-wide association studyMultivariate genome-wide association analysisGenome-wide association analysisMultiple correlated phenotypesGenetic signalsAssociation studiesCorrelated phenotypesAssociation analysisMultiple phenotypesSingle phenotypePhenotype
2014
Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall’s Tau
Jiang Y, Li N, Zhang H. Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall’s Tau. Journal Of The American Statistical Association 2014, 109: 905-930. PMID: 25382885, PMCID: PMC4219655, DOI: 10.1080/01621459.2014.901223.Peer-Reviewed Original ResearchGenome-wide association studiesGenetic variantsU-statisticsU-statistic methodNovel genetic variantsGWAS analysisPhenotype-genotype associationsEnvironmental factorsReplicable genetic variantsAssociation studiesSemiparametric methodAssociation analysisStatistical methodsStudy of AddictionParametric methodsGene-environment interactionsParametric estimatesInverse probability weightingSimulation resultsProbability weightingNull hypothesisVariantsKendall's tauGeneticsTraits
2013
NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
Zuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X. NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug And Alcohol Dependence 2013, 129: 254-264. PMID: 23455491, PMCID: PMC3628730, DOI: 10.1016/j.drugalcdep.2013.02.006.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesExpression quantitative loci (eQTL) analysisGene regionMetabolic pathwaysQuantitative loci analysisSNP-expression associationsCis-acting regulatory effectsDiscovery sampleSNP-disease associationsNumerous genesReplication sampleLocus analysisAssociation studiesAssociation analysisRisk SNPsTranscript expressionSNPsRegulatory effectsGenesPathwayEuropean descentExpression
2012
Large Scale Association Analysis for Drug Addiction: Results from SNP to Gene
Guo X, Liu Z, Wang X, Zhang H. Large Scale Association Analysis for Drug Addiction: Results from SNP to Gene. The Scientific World JOURNAL 2012, 2012: 939584. PMID: 23365539, PMCID: PMC3543790, DOI: 10.1100/2012/939584.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesAssociation analysisGene-based association analysisLarge-scale association analysisSingle nucleotide polymorphism dataWide association studyComplex diseasesGene-based analysisGene-based methodsNucleotide polymorphism dataGenetic association studiesPolymorphism dataGene findingGenetic variantsIndividual SNPsStudy of AddictionSNPsGenetic etiologyGenesComprehensive analysisGeneticsVariantsGenome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependence
Zuo L, Zhang F, Zhang H, Zhang X, Wang F, Li C, Lu L, Hong J, Lu L, Krystal J, Deng H, Luo X. Genome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 437-444. PMID: 22488850, PMCID: PMC3405545, DOI: 10.1002/ajmg.b.32047.Peer-Reviewed Original ResearchConceptsChromosome 3Genome-wide false discovery rateGene regionFalse discovery rateGenome-wide association analysisExpression quantitative trait loci (eQTL) analysisQuantitative trait locus (QTL) analysisRisk SNPsTranscript expressionGenome-wide association strategyGenome-wide searchCombined P valueSNP-disease associationsAssociation peakGenomic regionsEQTL analysisEuropean American casesCausal lociLocus analysisGene expressionAssociation analysisGenesSNPsRegulatory effectsDiscovery rate
2011
Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorder
Jiang Y, Zhang H. Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorder. Genetic Epidemiology 2011, 35: 125-132. PMID: 21254220, PMCID: PMC3077545, DOI: 10.1002/gepi.20558.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsGenetic variantsWellcome Trust Case Control ConsortiumRPGRIP1L geneGenetic studiesAssociation analysisHaplotype blocksChromosome 16Nucleotide polymorphismsComplex diseasesGenesComplex disorderStrong signalUnreported regionsVariantsImportant roleStrong evidencePolymorphismBipolar disorderRegion
2009
A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines
Zhu W, Cho K, Chen X, Zhang M, Wang M, Zhang H. A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines. BMC Proceedings 2009, 3: s119. PMID: 20017984, PMCID: PMC2795891, DOI: 10.1186/1753-6561-3-s7-s119.Peer-Reviewed Original ResearchTraits of interestGenome-wide analysisGenome-wide association studiesWide association analysisGenome-wide dataMultivariate adaptive splinesAssociation studiesAssociation analysisGene-environment interactionsTraitsLongitudinal phenotypesGene-environment interaction effectsMasalFramingham Heart StudyPermutation testGenesPhenotype
2006
Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies
Zhang H, Wang X, Ye Y. Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies. Genetics 2006, 172: 693-699. PMID: 16219774, PMCID: PMC1456175, DOI: 10.1534/genetics.105.049122.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsQuantitative traitsOrdinal traitsTraditional linkage studiesGenomewide association analysisAssociation of genesDetection of genesGametic disequilibriumLoci existAssociation studiesAssociation analysisGenesLinkage disequilibriumTraitsComplex diseasesLinkage studiesGrowth-associated protein 43Protein 43DisequilibriumPolymorphismFamilyMarkersNuclear families
2005
A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking
Ye Y, Zhong X, Zhang H. A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking. BMC Genomic Data 2005, 6: s135. PMID: 16451594, PMCID: PMC1866801, DOI: 10.1186/1471-2156-6-s1-s135.Peer-Reviewed Original ResearchConceptsAssociation analysisGenetic Analysis Workshop 14Single nucleotide polymorphism dataJoint association analysisNew genesSingle nucleotide polymorphismsGenetic mechanismsPolymorphism dataAssociation studiesDeterministic forestsGenetics of AlcoholismGenesTreesUseful candidateGeneticsForestPolymorphismFuture studiesStudy of alcoholismLinkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data
Zhong X, Zhang H. Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data. BMC Genomic Data 2005, 6: s31. PMID: 16451641, PMCID: PMC1866754, DOI: 10.1186/1471-2156-6-s1-s31.Peer-Reviewed Original ResearchConceptsLinkage analysisAssociation analysisSusceptibility genesGenetic Analysis Workshop 14Alcoholism dataCombination of linkageComplex disease mappingDisease susceptibility genesEntire genomeMean identityLinkage disequilibriumTransmission/disequilibrium testAssociation TestGenesPresence of linkageDisequilibrium testGenomeChromosomesGeneticsLinkageDisequilibriumAssociation strategyGreater numberRegion
2001
Tree‐Based Linkage and Association Analyses of Asthma
Zhang H, Tsai C, Yu C, Bonney G. Tree‐Based Linkage and Association Analyses of Asthma. Genetic Epidemiology 2001, 21: s317-s322. PMID: 11793691, DOI: 10.1002/gepi.2001.21.s1.s317.Peer-Reviewed Original ResearchConceptsGenetic Analysis Workshop 12Chromosome 1Association studiesLinkage analysisAssociation analysisStrong evidenceLinkageData sets