2007
Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study
McLaughlin JR, Risch HA, Lubinski J, Moller P, Ghadirian P, Lynch H, Karlan B, Fishman D, Rosen B, Neuhausen SL, Offit K, Kauff N, Domchek S, Tung N, Friedman E, Foulkes W, Sun P, Narod SA, Group O. Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. The Lancet Oncology 2007, 8: 26-34. PMID: 17196508, DOI: 10.1016/s1470-2045(06)70983-4.Peer-Reviewed Original ResearchConceptsInvasive ovarian cancerCarriers of BRCA1Case-control studyOral contraceptivesOvarian cancerBRCA2 mutationsTubal ligationRisk factorsBRCA1 mutationsReproductive risk factorsPopulation-based studyOvarian cancer riskPossible adverse effectsYear of birthInternational registryMenstrual cycleOdds ratioBreast cancerMutation carriersReproductive historyContraceptivesBRCA2 genesCancerAdverse effectsWomen
2006
PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer
Risch HA, Bale AE, Beck PA, Zheng W. PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 1738-1741. PMID: 16985038, DOI: 10.1158/1055-9965.epi-06-0272.Peer-Reviewed Original ResearchConceptsOvarian cancerA allelePostmenopausal womenProgesterone receptor gene polymorphismHistologic tumor typePopulation-based studyEpithelial ovarian cancerEffect of progesteroneReceptor gene polymorphismsPremenopausal womenEndometrial cancerMenopausal statusOral contraceptivesOvarian neoplasiaProgesterone receptorProgestin exposureG genotypeGG genotypeGene polymorphismsTumor typesReceptor isoformsCancerWomenRiskProgesterone
2004
Smoking and ovarian cancer
Halick C, Risch H. Smoking and ovarian cancer. 2004, 511-521. DOI: 10.1093/oso/9780198526872.003.0030.Peer-Reviewed Original Research
2001
Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives
Runnebaum I, Wang-Gohrke S, Vesprini D, Kreienberg R, Lynch H, Moslehi R, Ghadirian P, Weber B, Godwin A, Risch H, Garber J, Lerman C, Olopade O, Foulkes W, Karlan B, Warner E, Rosen B, Rebbeck T, Tonin P, Dubé M, Kieback D, Narod S. Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives. Pharmacogenetics And Genomics 2001, 11: 635-638. PMID: 11668223, DOI: 10.1097/00008571-200110000-00010.Peer-Reviewed Original ResearchConceptsPROGINS alleleOvarian cancerOral contraceptivesBRCA2 mutationsCarriers of BRCA1Oral contraceptive useOvarian cancer riskHereditary ovarian cancerBRCA2 mutation carriersOral contraception useForms of cancerYear of birthPrior diagnosisBRCA2 carriersProgesterone receptorBreast cancerMutation carriersContraceptive useCancer riskContraception useHereditary breastDisease statusPast exposureCancerBRCA1 mutations
1998
Oral Contraceptives and the Risk of Hereditary Ovarian Cancer
Narod S, Risch H, Moslehi R, Dørum A, Neuhausen S, Olsson H, Provencher D, Radice P, Evans G, Bishop S, Brunet J, Ponder B, Klijn J. Oral Contraceptives and the Risk of Hereditary Ovarian Cancer. New England Journal Of Medicine 1998, 339: 424-428. PMID: 9700175, DOI: 10.1056/nejm199808133390702.Peer-Reviewed Original ResearchConceptsOral contraceptive useHereditary ovarian cancerOvarian cancerOral contraceptivesControl womenBRCA2 genesPathogenic mutationsCase-control studyHigh lifetime riskDuration of useYear of birthLifetime riskOdds ratioBRCA2 mutationsLifetime historyHereditary formsCancerBRCA1 mutationsContraceptivesWomenPatientsRiskMore yearsPast useBRCA1
1996
Differences in Risk Factors for Epithelial Ovarian Cancer by Histologic Type
Risch H, Marrett L, Jain M, Howe G. Differences in Risk Factors for Epithelial Ovarian Cancer by Histologic Type. American Journal Of Epidemiology 1996, 144: 363-372. PMID: 8712193, DOI: 10.1093/oxfordjournals.aje.a008937.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerMucinous tumorsNonmucinous tumorsOvarian cancerHistologic typeOdds ratioPrimary epithelial ovarian cancerUnconditional logistic regression methodsInvasive serous cancerMucinous ovarian tumorsOral contraceptive useFull-term pregnancyRisk factor associationsCase-control studyOral contraceptivesSerous cancerEndometrioid cancerNoncontraceptive estrogensFat intakeInvasive cancerOvarian tumorsRisk factorsEpithelial tumorsReproductive factorsContraceptive use
1983
EVENTS OF REPRODUCTIVE LIFE AND THE INCIDENCE OF EPITHELIAL OVARIAN CANCER
RISCH H, WEISS N, LYON J, DALING J, LIFF J. EVENTS OF REPRODUCTIVE LIFE AND THE INCIDENCE OF EPITHELIAL OVARIAN CANCER. American Journal Of Epidemiology 1983, 117: 128-139. PMID: 6681935, DOI: 10.1093/oxfordjournals.aje.a113523.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerOvarian cancerOral contraceptionInhibition of ovulationPituitary gonadotrophin secretionLack of associationThyroid medicationOral contraceptivesNoncontraceptive estrogensGonadotrophin secretionMedical historyRelative riskDiminished riskTotal doseYears of lactationCancerLogistic regression methodReproductive lifePregnancyMiscarriageRiskContraceptionRandom sampleWomenLactation