2024
Excess Cardiovascular Mortality Among Black Americans 2000-2022: A JACC Report Card
Arun A, Sawano M, Lu Y, Warner F, Caraballo C, Khera R, Echols M, Yancy C, Krumholz H. Excess Cardiovascular Mortality Among Black Americans 2000-2022: A JACC Report Card. Journal Of The American College Of Cardiology 2024 PMID: 38901531, DOI: 10.1016/j.jacc.2024.06.004.Peer-Reviewed Original ResearchIncorporating Medicare Advantage Admissions Into the CMS Hospital-Wide Readmission Measure
Kyanko K, Sahay K, Wang Y, Li S, Schreiber M, Hager M, Myers R, Johnson W, Zhang J, Krumholz H, Suter L, Triche E. Incorporating Medicare Advantage Admissions Into the CMS Hospital-Wide Readmission Measure. JAMA Network Open 2024, 7: e2414431. PMID: 38829614, PMCID: PMC11148674, DOI: 10.1001/jamanetworkopen.2024.14431.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesSpecialty subgroupsPerformance quintileMedicare AdvantageReadmission ratesRisk-standardized readmission ratesHospital-wide readmission measureHospital outcome measuresTest-retest reliabilityRisk-adjustment variablesMeasurement reliabilityAdministrative claims dataReadmission measuresImprove measurement reliabilityIntegrated data repositoryMA beneficiariesQuintile rankingsMedicare beneficiariesMedicaid ServicesAll-causePublic reportingStudy assessed differencesClaims dataOutcome measuresMA cohortA Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structureCost-effectiveness of bevacizumab therapy in the care of patients with hereditary hemorrhagic telangiectasia
Wang D, Ito S, Waldron C, Butt A, Zhang E, Krumholz H, Al-Samkari H, Goshua G. Cost-effectiveness of bevacizumab therapy in the care of patients with hereditary hemorrhagic telangiectasia. Blood Advances 2024, 8: 2835-2845. PMID: 38537061, PMCID: PMC11176968, DOI: 10.1182/bloodadvances.2024012589.Peer-Reviewed Original ResearchIncremental net monetary benefitHereditary hemorrhagic telangiectasiaStandard-of-careBevacizumab therapyWillingness-to-payNet monetary benefitHemorrhagic telangiectasiaWillingness-to-pay thresholdsStandard-of-care strategiesCare of patientsCost-effectiveness analysisAnti-VEGF bevacizumabSystemic antiangiogenic therapyCurrent standard-of-careMonetary benefitsTime horizonFormulary placementHealthcare resource utilizationStandard of careLifetime time horizonPatient quality-of-lifeScenario analysisProbabilistic sensitivity analysesIV bevacizumabAnti-VEGFStrokeClassifier: ischemic stroke etiology classification by ensemble consensus modeling using electronic health records
Lee H, Schwamm L, Sansing L, Kamel H, de Havenon A, Turner A, Sheth K, Krishnaswamy S, Brandt C, Zhao H, Krumholz H, Sharma R. StrokeClassifier: ischemic stroke etiology classification by ensemble consensus modeling using electronic health records. Npj Digital Medicine 2024, 7: 130. PMID: 38760474, PMCID: PMC11101464, DOI: 10.1038/s41746-024-01120-w.Peer-Reviewed Original ResearchElectronic health recordsWeighted F1MIMIC-IIIClinical decision support systemsMulti-class classificationNatural language processingMIMIC-III datasetHealth recordsMachine learning classifiersDecision support systemArtificial intelligence toolsVascular neurologistsLearning classifiersBinary classificationCross-validation accuracyLanguage processingMeta-modelIntelligence toolsStroke prevention effortsAcute ischemic strokeStroke etiologySupport systemStroke etiology classificationClassification toolClassifierCost-effectiveness of rapid vs in-house vs send-out ADAMTS13 testing for immune thrombotic thrombocytopenic purpura
Allen C, Ito S, Butt A, Purcell A, Richmond R, Tormey C, Krumholz H, Cuker A, Goshua G. Cost-effectiveness of rapid vs in-house vs send-out ADAMTS13 testing for immune thrombotic thrombocytopenic purpura. Blood Advances 2024, 8: 2279-2289. PMID: 38502197, PMCID: PMC11116991, DOI: 10.1182/bloodadvances.2024012608.Peer-Reviewed Original ResearchImmune thrombotic thrombocytopenic purpuraPLASMIC scoreThrombotic thrombocytopenic purpuraThrombocytopenic purpuraADAMTS13 testingIncremental net monetary benefitPer-patient cost savingsTherapeutic plasma exchangeBase-case analysisMarkov cohort simulationProbabilistic sensitivity analysesAmount of QALYEmpirical therapyADAMTS13 assaysPlasma exchangeEmpirical treatmentCaplacizumabFRET-based assayPrimary outcomePatientsNet monetary benefitCohort simulationCost-effectiveness evaluationPurpuraTesting strategiesThe PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID
Krumholz H, Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li S, Herrin J, Coppi A, Holub J, Henriquez Y, Johnson M, Goddard T, Rocco E, Hummel A, Al Mouslmani M, Putrino D, Carr K, Carvajal-Gonzalez S, Charnas L, De Jesus M, Ziegler F, Iwasaki A. The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID. The American Journal Of Medicine 2024 PMID: 38735354, DOI: 10.1016/j.amjmed.2024.04.030.Peer-Reviewed Original ResearchLC trialPROMIS-29Participants' homesTargeting viral persistencePlacebo-controlled trialDouble-blind studyElectronic health recordsCore Outcome MeasuresLong COVIDEQ-5D-5LRepeated measures analysisEvidence-based treatmentsPhase 2Double-blindParticipant-centred approachStudy drugPrimary endpointSecondary endpointsCommunity-dwellingHealth recordsHealthcare utilizationContiguous US statesViral persistencePatient groupDrug treatmentSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stayHospital Variation in the Use of Intravenous Benzodiazepines for Sedation During Early Mechanical Ventilation
Jain S, Gershengorn H, Priya A, Walkey A, Burry L, Krumholz H, Wunsch H, Lindenauer P. Hospital Variation in the Use of Intravenous Benzodiazepines for Sedation During Early Mechanical Ventilation. 2024, a1095-a1095. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1095.Peer-Reviewed Original ResearchHypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records
Brush J, Lu Y, Liu Y, Asher J, Li S, Sawano M, Young P, Schulz W, Anderson M, Burrows J, Krumholz H. Hypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records. Journal Of The American Heart Association 2024, 13: e033253. PMID: 38686864, PMCID: PMC11179912, DOI: 10.1161/jaha.123.033253.Peer-Reviewed Original ResearchConceptsElectronic health recordsRegional health systemImprove hypertension careHealth systemHealth recordsHypertension careDiastolic blood pressureAge-adjusted prevalence ratesNon-Hispanic Black patientsPrevalence ratesLarger health systemCross-sectional analysisTransformation of medical dataLeveraging real-world dataHigh prevalence rateHypertension trendsHypertension prevalenceBlood pressureBlood pressure measurementsHypertension diagnosisPrimary outcomeNational trendsProportion of patientsAntihypertensive medicationsBlack patientsHospital Variation in Delivery of Skilled Rehabilitation to Mechanically Ventilated Older Adults With Acute Respiratory Failure
Jimenez Ceja J, Zhang L, Lin Z, Walkey A, Krumholz H, Jain S. Hospital Variation in Delivery of Skilled Rehabilitation to Mechanically Ventilated Older Adults With Acute Respiratory Failure. 2024, a1096-a1096. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1096.Peer-Reviewed Original ResearchLong COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort
Sawano M, Wu Y, Shah R, Zhou T, Arun A, Khosla P, Kaleem S, Vashist A, Bhattacharjee B, Ding Q, Lu Y, Caraballo C, Warner F, Huang C, Herrin J, Putrino D, Michelsen T, Fisher L, Adinig C, Iwasaki A, Krumholz H. Long COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort. The American Journal Of Medicine 2024 PMID: 38663793, DOI: 10.1016/j.amjmed.2024.04.015.Peer-Reviewed Original ResearchExperiences of peopleHealth statusLong COVIDLower health statusNew-onset conditionsCommunity support servicesNon-Hispanic whitesArray of healthQuality of lifeVisual analogue scaleMental healthPsychological distressPsychological statusDescriptive studyHealthcare systemMedian scoreSupport servicesResearch cohortSocial isolationDemographic characteristicsAnalogue scaleImpact of long COVIDHealthFinancial stressParticipantsFactors Associated with Long COVID Recovery among US Adults
Shah K, Shah R, Sawano M, Wu Y, Bishop P, Iwasaki A, Krumholz H. Factors Associated with Long COVID Recovery among US Adults. The American Journal Of Medicine 2024 PMID: 38649004, DOI: 10.1016/j.amjmed.2024.04.017.Peer-Reviewed Original ResearchUS adultsNational Health Interview SurveyNon-institutionalized US adultsLong COVIDFactors associated with Long COVIDReport recoveryHealth Interview SurveyNationally representative estimatesMultivariate logistic regression modelHigh school degreeLogistic regression modelsCOVID-19 symptomsCross-sectional sampleMultivariate logistic regression analysisNational survey dataHispanic adultsLogistic regression analysisInterview SurveyWhite adultsRepresentative estimatesAmerican adultsStudy sampleSchool degreeNonresponse biasRegression modelsReal-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study
Oikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.Peer-Reviewed Original ResearchRisk of acute myocardial infarctionAssociated with lower oddsHospital health systemCoronary artery diseaseCardiac testingRisk of adverse outcomesUK BiobankHealth systemProvider-drivenLower oddsAssociated with better outcomesAcute myocardial infarctionBlack raceStable chest painFemale sexReal world evaluationDiabetes historyMulticohort studyFunction testsSuspected coronary artery diseaseYounger ageRisk profileAdverse outcomesMultinational cohortPost hoc analysisRacial Differences in 1-Year Mortality after Hospitalization for Chronic Obstructive Pulmonary Disease in the United States.
Jain S, Priya A, Pekow P, Spitzer K, Walkey A, Opara I, Krumholz H, Lindenauer P. Racial Differences in 1-Year Mortality after Hospitalization for Chronic Obstructive Pulmonary Disease in the United States. Annals Of The American Thoracic Society 2024, 21: 585-594. PMID: 37943953, PMCID: PMC10995557, DOI: 10.1513/annalsats.202304-359oc.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseChronic obstructive pulmonary disease hospitalizationsObstructive pulmonary diseaseMedicare beneficiariesWhite racePulmonary diseaseChronic obstructive pulmonary disease exacerbationsChronic obstructive pulmonary disease patientsObstructive pulmonary disease exacerbationsObstructive pulmonary disease patientsHospital-level clusteringPulmonary disease exacerbationsRetrospective cohort studyPulmonary disease patientsCox regression modelIndividual socioeconomic statusDisease exacerbationPulmonary rehabilitationCohort studyDischarge dispositionOverall mortalityIllness severityHospitalized populationCare factorsDisease patientsHYPERTENSION EXCESS MORTALITY AND YEARS OF POTENTIAL LIFE LOST IN BLACK AMERICANS: A TWO-DECADE ANALYSIS INCLUDING THE COVID-19 PANDEMIC
Lu Y, Arun A, Khosla P, Kaleem S, Sawano M, Herrin J, Caraballo C, Murugiah K, Khera R, Watson K, Taylor H, AL Mouslmani M, Krumholz H. HYPERTENSION EXCESS MORTALITY AND YEARS OF POTENTIAL LIFE LOST IN BLACK AMERICANS: A TWO-DECADE ANALYSIS INCLUDING THE COVID-19 PANDEMIC. Journal Of The American College Of Cardiology 2024, 83: 1675. DOI: 10.1016/s0735-1097(24)03665-9.Peer-Reviewed Original ResearchCOMPARATIVE CARDIOVASCULAR EFFECTIVENESS OF ANTI-HYPERGLYCEMIC AGENTS INITIATED AS SECOND-LINE THERAPY IN TYPE 2 DIABETES: A LARGE-SCALE, MULTINATIONAL, FEDERATED TARGET TRIAL EMULATION IN THE LEGEND-T2DM STUDY
Khera R, Aminorroaya A, Dhingra L, Bu F, Camargos A, Falconer T, Zhou J, Dorr D, French T, Lau W, Lu Y, Blacketer C, Reyes C, Minty E, Li K, Man K, Ostropolets A, Nishimura A, Matheny M, Yang J, Ryan P, Y.F. W, Krumholz H, Hripcsak G, Suchard M. COMPARATIVE CARDIOVASCULAR EFFECTIVENESS OF ANTI-HYPERGLYCEMIC AGENTS INITIATED AS SECOND-LINE THERAPY IN TYPE 2 DIABETES: A LARGE-SCALE, MULTINATIONAL, FEDERATED TARGET TRIAL EMULATION IN THE LEGEND-T2DM STUDY. Journal Of The American College Of Cardiology 2024, 83: 1977. DOI: 10.1016/s0735-1097(24)03967-6.Peer-Reviewed Original ResearchEXCESS ISCHEMIC HEART DISEASE MORTALITY AND YEARS OF POTENTIAL LIFE LOST AMONG THE BLACK POPULATION: A TWO-DECADE ANALYSIS INCLUDING THE COVID-19 PANDEMIC
Sawano M, Khosla P, Arun A, Kaleem S, AL Mouslmani M, Caraballo C, Lu Y, Herrin J, Murugiah K, Khera R, Taylor H, Watson K, Yancy C, Krumholz H. EXCESS ISCHEMIC HEART DISEASE MORTALITY AND YEARS OF POTENTIAL LIFE LOST AMONG THE BLACK POPULATION: A TWO-DECADE ANALYSIS INCLUDING THE COVID-19 PANDEMIC. Journal Of The American College Of Cardiology 2024, 83: 1193. DOI: 10.1016/s0735-1097(24)03183-8.Peer-Reviewed Original ResearchPatient Privacy and Data Provenance in Pulmonary and Critical Care Research Using Big Data.
Jain S, Krumholz H. Patient Privacy and Data Provenance in Pulmonary and Critical Care Research Using Big Data. Annals Of The American Thoracic Society 2024, 21: 538-540. PMID: 38259228, PMCID: PMC10995548, DOI: 10.1513/annalsats.202305-497ip.Peer-Reviewed Original ResearchSEX DIFFERENCES IN TREATMENT STRATEGIES FOR PULMONARY EMBOLISM IN OLDER ADULTS: THE SERIOUS-PE STUDY
Bikdeli B, Jimenez D, Garcia A, Lin Z, Piazza G, Leyva H, Khairani C, Rosovsky R, Mehdipoor G, O'Donoghue M, LOPEZ-SAEZ J, Madridano O, Grandone E, Lu Y, López-Jiménez L, Gerhard-Herman M, Molina Á, Bertoletti L, Goldhaber S, Bates S, Krumholz H, Monreal M. SEX DIFFERENCES IN TREATMENT STRATEGIES FOR PULMONARY EMBOLISM IN OLDER ADULTS: THE SERIOUS-PE STUDY. Journal Of The American College Of Cardiology 2024, 83: 2262. DOI: 10.1016/s0735-1097(24)04252-9.Peer-Reviewed Original Research