2022
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease
Khera AV, Wang M, Chaffin M, Emdin CA, Samani NJ, Schunkert H, Watkins H, McPherson R, Erdmann J, Elosua R, Boerwinkle E, Ardissino D, Butterworth A, Di Angelantonio E, Naheed A, Danesh J, Chowdhury R, Krumholz H, Sheu W, Rich S, Rotter J, Chen Y, Gabriel S, Lander E, Saleheen D, Kathiresan S. Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. Circulation Genomic And Precision Medicine 2022, 15: e003598. PMID: 36215124, PMCID: PMC9771961, DOI: 10.1161/circgen.121.003598.Peer-Reviewed Original ResearchMeSH KeywordsCholesterolCoronary Artery DiseaseHumansHypercholesterolemiaNitric OxidePolymorphism, GeneticConceptsMolecular subtypesCAD riskHigher systolic blood pressureCoronary artery disease patientsEndothelial nitric oxide synthase geneDamaging missense variantsRisk of CADSystolic blood pressureCoronary artery diseaseRisk of hypertensionNitric oxide synthase geneMissense variantsNitric oxide synthesisRare variantsOxide synthase geneDiscrete molecular subtypesNitric Oxide SignalingLow density lipoprotein receptor geneArtery diseaseBlood pressureEndothelial functionVascular toneDisease patientsCAD casesCholesterol concentrations
2014
Impact of the ENHANCE Trial on the use of ezetimibe in the United States and Canada
Lu L, Krumholz HM, Tu JV, Ross JS, Ko DT, Jackevicius CA. Impact of the ENHANCE Trial on the use of ezetimibe in the United States and Canada. American Heart Journal 2014, 167: 683-689. PMID: 24766978, PMCID: PMC4215424, DOI: 10.1016/j.ahj.2014.01.014.Peer-Reviewed Original ResearchConceptsUse of ezetimibeENHANCE trialEzetimibe useProgression of atherosclerosisMain outcome measuresAtherosclerosis regression trialsMonthly numberOutcome measuresRegression trialsEzetimibeIMS HealthCommon evidence baseEvidence baseTrialsUnited StatesUtilization patternsFurther investigationDifferent utilization patternsPopulationDifferent patternsUse trendsAtherosclerosisSimvastatinProgression
2012
Three Reasons to Abandon Low-Density Lipoprotein Targets
Hayward RA, Krumholz HM. Three Reasons to Abandon Low-Density Lipoprotein Targets. Circulation Cardiovascular Quality And Outcomes 2012, 5: 2-5. PMID: 22253366, DOI: 10.1161/circoutcomes.111.964676.Peer-Reviewed Original Research
2008
Use of Recommended Ambulatory Care Services: Is the Veterans Affairs Quality Gap Narrowing?
Ross JS, Keyhani S, Keenan PS, Bernheim SM, Penrod JD, Boockvar KS, Federman AD, Krumholz HM, Siu AL. Use of Recommended Ambulatory Care Services: Is the Veterans Affairs Quality Gap Narrowing? JAMA Internal Medicine 2008, 168: 950-958. PMID: 18474759, DOI: 10.1001/archinte.168.9.950.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmbulatory CareBehavioral Risk Factor Surveillance SystemBreast NeoplasmsCholesterolColorectal NeoplasmsCounselingDiabetes MellitusDiabetic RetinopathyDisease ManagementDyslipidemiasFemaleHospitals, VeteransHumansInfluenza VaccinesMaleMiddle AgedPneumococcal VaccinesPreventive Health ServicesQuality of Health CareSmoking CessationUnited StatesVeteransConceptsVeterans Affairs Medical CenterAmbulatory care servicesInsured adultsCancer screeningCare servicesBehavior Risk Factor Surveillance SystemRisk Factor Surveillance SystemCardiovascular risk reductionColorectal cancer screeningChronic disease careBreast cancer screeningQuality improvement initiativesQuality of careUS health care systemInfectious disease preventionHealth care systemHealth Care Quality Improvement InitiativeEye examinationSelf-reported useDisease careCancer preventionMellitus managementMedical CenterAmbulatory careService use
2005
Knowledge of Cholesterol Levels and Targets in Patients With Coronary Artery Disease
Cheng S, Lichtman JH, Amatruda JM, Smith GL, Mattera JA, Roumanis SA, Krumholz HM. Knowledge of Cholesterol Levels and Targets in Patients With Coronary Artery Disease. Preventive Cardiology 2005, 8: 11-17. PMID: 15722689, DOI: 10.1111/j.1520-037x.2005.3939.x.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHigh-density lipoproteinLow-density lipoproteinCholesterol targetsArtery diseaseCholesterol levelsMultiple cardiac risk factorsCardiac risk factorsTotal cholesterol levelsTotal cholesterol valuesRisk factorsCardiovascular diseaseCholesterol valuesPrevious historyPatientsLipoproteinDiseaseCollege educationWomenNonwhitesEducation effortsNational targetsTargetCholesterol
2003
Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint
Foody JM, Krumholz HM. Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint. The American Journal Of Geriatric Cardiology 2003, 12: 357-360. PMID: 14610384, DOI: 10.1111/j.1076-7460.2003.02912.x.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePrimary preventionArtery diseaseOvert coronary artery diseaseRisk of myositisCardiovascular disease eventsRole of statinsUse of statinsAge 65 yearsBalance of risksCardiovascular eventsStatin therapyPatient preferencesCholesterol levelsCardiovascular diseaseOctogenariansClinical uncertaintyDisease eventsCurrent evidenceStatinsAge groupsDiseasePreventionRiskMyositisLong‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project
Foody JM, Wang Y, Kiefe CI, Ellerbeck EF, Gold J, Radford MJ, Krumholz HM. Long‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project. Journal Of The American Geriatrics Society 2003, 51: 930-936. PMID: 12834512, DOI: 10.1046/j.1365-2389.2003.51305.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal serum cholesterolElevated total serum cholesterolCoronary artery diseaseCause mortalityTotal cholesterolSerum cholesterolElderly survivorsPrognostic importanceMyocardial infarctionCholesterol levelsLong-term prognostic importanceRetrospective medical record reviewAdjusted hazard ratioMedical record reviewLower total cholesterolStudy inclusion criteriaYear of dischargePrimary endpointOlder patientsArtery diseaseHazard ratioRecord reviewAcute careLipid subfractions
1999
Editorial
Chen YT, Krumholz HM. Editorial. Nutrition 1999, 15: 242-244. PMID: 10198923, DOI: 10.1016/s0899-9007(98)00187-7.Peer-Reviewed Original Research
1996
Cholesterol and Coronary Heart Disease Mortality in Elderly Patients
Krumholz H, Vaccarino V, de Leon C, Seeman T, Berkman L. Cholesterol and Coronary Heart Disease Mortality in Elderly Patients. JAMA 1996, 275: 110-110. PMID: 8531301, DOI: 10.1001/jama.1996.03530260024018.Peer-Reviewed Original Research
1994
Lack of Association Between Cholesterol and Coronary Heart Disease Mortality and Morbidity and All-Cause Mortality in Persons Older Than 70 Years
Krumholz HM, Seeman TE, Merrill SS, Mendes de Leon CF, Vaccarino V, Silverman DI, Tsukahara R, Ostfeld AM, Berkman LF. Lack of Association Between Cholesterol and Coronary Heart Disease Mortality and Morbidity and All-Cause Mortality in Persons Older Than 70 Years. JAMA 1994, 272: 1335-1340. PMID: 7772105, DOI: 10.1001/jama.1994.03520170045034.Peer-Reviewed Original ResearchConceptsCoronary heart disease mortalityHeart disease mortalityTotal serum cholesterolSerum cholesterol levelsRisk factor-adjusted odds ratioFactor-adjusted odds ratiosTotal serum cholesterol levelsCause mortalityCoronary heart diseaseHDL-C levelsUnstable anginaHighest tertileCholesterol levelsSerum cholesterolMyocardial infarctionDisease mortalityLow HDLLowest tertileHeart diseaseRisk factorsOdds ratioElevated total serum cholesterol levelsHigher total serum cholesterolCommunity-based cohort studyHigh-density lipoprotein cholesterol