2017
Implications of Coronary Artery Calcium Testing for Treatment Decisions Among Statin Candidates According to the ACC/AHA Cholesterol Management Guidelines A Cost-Effectiveness Analysis
Hong JC, Blankstein R, Shaw LJ, Padula WV, Arrieta A, Fialkow JA, Blumenthal RS, Blaha MJ, Krumholz HM, Nasir K. Implications of Coronary Artery Calcium Testing for Treatment Decisions Among Statin Candidates According to the ACC/AHA Cholesterol Management Guidelines A Cost-Effectiveness Analysis. JACC Cardiovascular Imaging 2017, 10: 938-952. PMID: 28797417, DOI: 10.1016/j.jcmg.2017.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmerican Heart AssociationBayes TheoremClinical Decision-MakingComputer SimulationCoronary AngiographyCoronary Artery DiseaseCoronary VesselsCost-Benefit AnalysisDecision Support TechniquesDrug CostsFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedModels, EconomicMonte Carlo MethodMultivariate AnalysisPractice Guidelines as TopicPredictive Value of TestsQuality of LifeQuality-Adjusted Life YearsTime FactorsTreatment OutcomeUnited StatesVascular CalcificationConceptsCoronary artery calciumQuality-adjusted life yearsStatin therapyArtery calciumLong-term statin therapyAtherosclerotic cardiovascular disease eventsCholesterol management guidelinesIncremental cost-effectiveness ratioCardiovascular disease eventsAtherosclerotic cardiovascular diseaseCost-effectiveness ratioCost-effectiveness analysisStatin candidatesCholesterol managementCardiovascular diseaseTreatment decisionsAmerican CollegeDisease eventsLifetime horizonLife yearsAmerican HeartSocietal perspectiveManagement guidelinesStatinsPatients
2012
Procedure Intensity and the Cost of Care
Chen SI, Dharmarajan K, Kim N, Strait KM, Li SX, Safavi KC, Lindenauer PK, Krumholz HM, Lagu T. Procedure Intensity and the Cost of Care. Circulation Cardiovascular Quality And Outcomes 2012, 5: 308-313. PMID: 22576844, PMCID: PMC3415230, DOI: 10.1161/circoutcomes.112.966069.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCosts and Cost AnalysisCross-Sectional StudiesFemaleHeart FailureHospital Bed CapacityHospital CostsHospital MortalityHospitalizationHospitals, RuralHospitals, TeachingHospitals, UrbanHumansLength of StayLinear ModelsMaleMiddle AgedModels, EconomicOutcome and Process Assessment, Health CareResidence CharacteristicsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsHF hospitalizationHeart failureInvasive proceduresHospital groupRisk-standardized mortality ratesProportion of patientsLength of stayCost of careWilcoxon rank sum testHigher procedure ratesRank sum testPatient demographicsPerspective databaseMedian lengthSurgical proceduresProcedure ratesHospitalizationOutcome differencesMortality rateHospitalPatientsPractice styleProcedure useSum testOverall use
2001
Predictors of costs of caring for elderly patients discharged with heart failure
Wexler D, Chen J, Smith G, Radford M, Yaari S, Bradford W, Krumholz H. Predictors of costs of caring for elderly patients discharged with heart failure. American Heart Journal 2001, 142: 350-357. PMID: 11479477, DOI: 10.1067/mhj.2001.116476.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overConnecticutFemaleHealth Services for the AgedHeart FailureHospital CostsHumansLength of StayMaleMedical RecordsMedicareModels, EconomicOutcome Assessment, Health CarePatient DischargePatient ReadmissionPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsConceptsHeart failureIndependent correlatesHeart failure-related admissionsHeart failure-related readmissionsSubstantial hospital costsHeart failure admissionsHistory of strokeSubset of patientsPrincipal discharge diagnosisSignificant independent correlatesOutcomes 6 monthsPredictors of costsMedicare administrative databasesCause readmissionClinical characteristicsElderly patientsAverage admissionDischarge diagnosisKidney failureCause costsCorrelates of costsMedical recordsRisk factorsAdministrative databasesConnecticut hospitals
1998
Clinical correlates of in-hospital costs for acute myocardial infarction in patients 65 years of age and older
Krumholz H, Chen J, Murillo J, Cohen D, Radford M. Clinical correlates of in-hospital costs for acute myocardial infarction in patients 65 years of age and older. American Heart Journal 1998, 135: 523-531. PMID: 9506340, DOI: 10.1016/s0002-8703(98)70331-x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPatients 65 yearsHospital costsMyocardial infarctionAcute myocardial infarction hospitalizationsActual clinical practiceMyocardial infarction hospitalizationsClinical characteristicsAdverse outcomesClinical correlatesMedical recordsClinical practiceHospital proceduresRoom costsInfarctionStudy sampleTotal meanRelative paucityAgeLarge proportionCorrelatesHospitalizationPatientsHospitalYears
1995
A cost-effectiveness model of thrombolytic therapy for acute myocardial infarction
Kalish S, Gurwitz J, Krumholz H, Avorn J. A cost-effectiveness model of thrombolytic therapy for acute myocardial infarction. Journal Of General Internal Medicine 1995, 10: 321-330. PMID: 7562123, DOI: 10.1007/bf02599951.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsTissue plasminogen activatorAcute myocardial infarctionAdditional quality-adjusted life yearMyocardial infarctionGUSTO trialThrombolytic therapyOne-year mortality dataOccluded Coronary Arteries (GUSTO-I) trialMortality dataPlasminogen activatorLong-term medical costsCoronary Arteries trialOne-year mortalityUse of streptokinaseInferior wall infarctionCost-effective therapyCost-effectiveness modelDecision analysis modelSurvival benefitSymptom onsetClinical outcomesRelative survival advantageThrombolytic agentsSurvival advantage