2023
Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States
Ma Y, Zang E, Opara I, Lu Y, Krumholz H, Chen K. Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States. Nature Human Behaviour 2023, 7: 2074-2083. PMID: 37653149, PMCID: PMC10901568, DOI: 10.1038/s41562-023-01694-7.Peer-Reviewed Original ResearchConceptsNon-Hispanic White peopleCVD deathMortality burdenNon-Hispanic black peopleCardiovascular disease mortality ratesDisease mortality ratesNon-Hispanic blacksRace/ethnicityMortality rateLong-term exposureWhite peopleEthnic disparitiesHealth benefitsHispanic peopleSignificant differencesBurdenDeathUS countiesEthnic groupsAbsolute disparityAssociationExposureEthnic minoritiesDisparitiesAmbient fine particulate matter (PM2.5) concentrations
2022
Trends in Racial and Ethnic Disparities in Barriers to Timely Medical Care Among Adults in the US, 1999 to 2018
Caraballo C, Ndumele CD, Roy B, Lu Y, Riley C, Herrin J, Krumholz HM. Trends in Racial and Ethnic Disparities in Barriers to Timely Medical Care Among Adults in the US, 1999 to 2018. JAMA Health Forum 2022, 3: e223856. PMID: 36306118, PMCID: PMC9617175, DOI: 10.1001/jamahealthforum.2022.3856.Peer-Reviewed Original ResearchConceptsTimely medical careSerial cross-sectional studyNational Health Interview SurveyCross-sectional studyHealth Interview SurveyMedical careLack of transportationEthnic disparitiesHispanics/LatinosWhite individualsEthnicity groupsInterview SurveyCost of careSelf-reported raceStudy cohortClinic hoursMAIN OUTCOMEMedical officesCarePrevalenceLatino individualsBlack individualsSignificant differencesSignificant increasePopulation groupsPercutaneous Left Atrial Appendage Occlusion in Comparison to Non‐Vitamin K Antagonist Oral Anticoagulant Among Patients With Atrial Fibrillation
Noseworthy PA, Van Houten HK, Krumholz HM, Kent DM, Abraham NS, Graff‐Radford J, Alkhouli M, Henk HJ, Shah ND, Gersh BJ, Friedman PA, Holmes DR, Yao X. Percutaneous Left Atrial Appendage Occlusion in Comparison to Non‐Vitamin K Antagonist Oral Anticoagulant Among Patients With Atrial Fibrillation. Journal Of The American Heart Association 2022, 11: e027001. PMID: 36172961, PMCID: PMC9673739, DOI: 10.1161/jaha.121.027001.Peer-Reviewed Original ResearchConceptsComposite end pointAtrial appendage occlusionOral anticoagulantsAtrial fibrillationLower riskMajor bleedingSystemic embolismIntracranial bleedingAppendage occlusionNon-Vitamin K Antagonist Oral AnticoagulantsIschemic stroke/systemic embolismK Antagonist Oral AnticoagulantsPrimary composite end pointPropensity score overlap weightingStroke/systemic embolismEnd pointHigh bleeding riskSignificant differencesAntithrombotic regimensBleeding riskCause mortalityBaseline characteristicsComposite outcomeIschemic strokeSecondary outcomes
2020
Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
You SC, Rho Y, Bikdeli B, Kim J, Siapos A, Weaver J, Londhe A, Cho J, Park J, Schuemie M, Suchard MA, Madigan D, Hripcsak G, Gupta A, Reich CG, Ryan PB, Park RW, Krumholz HM. Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. JAMA 2020, 324: 1640-1650. PMID: 33107944, PMCID: PMC7592033, DOI: 10.1001/jama.2020.16167.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAgedAged, 80 and overAlgorithmsAspirinCase-Control StudiesCause of DeathClopidogrelDatabases, FactualDyspneaFemaleHemorrhageHumansIschemiaMaleMiddle AgedMyocardial InfarctionNetwork Meta-AnalysisPercutaneous Coronary InterventionPropensity ScorePurinergic P2Y Receptor AntagonistsRecurrenceRepublic of KoreaRetrospective StudiesStrokeTicagrelorUnited StatesConceptsNet adverse clinical eventsAcute coronary syndromePercutaneous coronary interventionAdverse clinical eventsHemorrhagic eventsIschemic eventsHazard ratioCause mortalityCoronary syndromeCoronary interventionClinical eventsRisk of NACEClinical practiceLarge randomized clinical trialsPrimary end pointRetrospective cohort studyPropensity-matched pairsSummary hazard ratioRandomized clinical trialsRoutine clinical practiceSignificant differencesP2Y12 platelet inhibitorsTicagrelor groupCohort studySecondary outcomesNewly diagnosed diabetes and outcomes after acute myocardial infarction in young adults
Ding Q, Spatz ES, Lipska KJ, Lin H, Spertus JA, Dreyer RP, Whittemore R, Funk M, Bueno H, Krumholz HM. Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults. Heart 2020, 107: 657-666. PMID: 33082173, PMCID: PMC8005796, DOI: 10.1136/heartjnl-2020-317101.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth statusDischarge diagnosisPharmacological treatmentMyocardial infarctionShort-term health statusYoung AMI Patients (VIRGO) studyDisease-specific health statusYoung adultsQuality of lifeHospital complicationsHospital mortalityMedication initiationBaseline characteristicsClinical outcomesDiabetesPatientsDiagnosisPatient studiesMonthsComplicationsInfarctionSignificant differencesOutcomesMortality
2017
Systolic Blood Pressure Response in SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes): A Possible Explanation for Discordant Trial Results
Huang C, Dhruva SS, Coppi AC, Warner F, Li S, Lin H, Nasir K, Krumholz HM. Systolic Blood Pressure Response in SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes): A Possible Explanation for Discordant Trial Results. Journal Of The American Heart Association 2017, 6: e007509. PMID: 29133522, PMCID: PMC5721802, DOI: 10.1161/jaha.117.007509.Peer-Reviewed Original ResearchConceptsSystolic blood pressure responseBlood pressure responseTreatment groupsCause deathVisit variabilityDiscordant trialsBlood pressure trialStandard treatment groupPressure responseACCORD participantsPressure trialSBP responseHeart failureMean SBPPrimary outcomeSBPDiscordant resultsMean differenceSimilar interventionsTrial resultsTrialsSimilar mean differencesTreatment effectsSignificant differencesStrokeHospital-Readmission Risk — Isolating Hospital Effects from Patient Effects
Krumholz HM, Wang K, Lin Z, Dharmarajan K, Horwitz LI, Ross JS, Drye EE, Bernheim SM, Normand ST. Hospital-Readmission Risk — Isolating Hospital Effects from Patient Effects. New England Journal Of Medicine 2017, 377: 1055-1064. PMID: 28902587, PMCID: PMC5671772, DOI: 10.1056/nejmsa1702321.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesReadmission ratesObserved readmission ratesSimilar diagnosesHospital effectsDifferent hospitalsHospital readmission performanceRate of readmissionHospital readmission ratesLower readmission ratesStudy sampleYears of ageSignificant differencesMultiple admissionsReadmission outcomesOnly significant differencePatient effectsSame patientMedicare recipientsPatientsReadmission performanceRisk-standardized hospital readmission ratesHospitalHospital qualityQuartile
2016
Life Expectancy after Myocardial Infarction, According to Hospital Performance
Bucholz EM, Butala NM, Ma S, Normand ST, Krumholz HM. Life Expectancy after Myocardial Infarction, According to Hospital Performance. New England Journal Of Medicine 2016, 375: 1332-1342. PMID: 27705249, PMCID: PMC5118048, DOI: 10.1056/nejmoa1513223.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRisk-standardized mortality ratesMyocardial infarctionLife expectancyMortality rateHospital performanceCooperative Cardiovascular ProjectProportional hazards modelLong-term survivalCase-mix severityLonger life expectancySurvival benefitInfarctionMedicare beneficiariesPatientsHospital case mixCase mixHospitalSurvival curvesQuintileStudy sampleSignificant differencesEarly survivalExpectancySurvivalComparative Effectiveness of Generic Atorvastatin and Lipitor® in Patients Hospitalized with an Acute Coronary Syndrome
Jackevicius CA, Tu JV, Krumholz HM, Austin PC, Ross JS, Stukel TA, Koh M, Chong A, Ko DT. Comparative Effectiveness of Generic Atorvastatin and Lipitor® in Patients Hospitalized with an Acute Coronary Syndrome. Journal Of The American Heart Association 2016, 5: e003350. PMID: 27098970, PMCID: PMC4859299, DOI: 10.1161/jaha.116.003350.Peer-Reviewed Original ResearchConceptsGeneric atorvastatinACS hospitalizationSecondary outcomesClinical effectivenessAcute coronary syndrome hospitalizationPopulation-based cohort studyNew-onset diabetesAcute coronary syndromeDays of dischargePrespecified subgroup analysisPropensity-matched pairsInfrequent side effectsBrand-name medicationsSignificant differencesHealth care plansRecurrent ACSAdmission diagnosisAtorvastatin doseCardiovascular outcomesCoronary syndromeCohort studyRenal failureHeart failurePrimary outcomeMean age
2014
Predictors of clinical trial data sharing: exploratory analysis of a cross-sectional survey
Rathi VK, Strait KM, Gross CP, Hrynaszkiewicz I, Joffe S, Krumholz HM, Dzara K, Ross JS. Predictors of clinical trial data sharing: exploratory analysis of a cross-sectional survey. Trials 2014, 15: 384. PMID: 25277128, PMCID: PMC4192345, DOI: 10.1186/1745-6215-15-384.Peer-Reviewed Original ResearchMeSH KeywordsAccess to InformationAgedAttitude of Health PersonnelChi-Square DistributionClinical Trials as TopicCooperative BehaviorCross-Sectional StudiesDatabases, FactualFemaleHealth Knowledge, Attitudes, PracticeHumansInformation DisseminationInternetMaleMiddle AgedPerceptionRegistriesResearch PersonnelSurveys and QuestionnairesConceptsTrial funding sourceExact testMain outcome measuresFisher's exact testCross-sectional surveyChi-square testClinical trialsTrial characteristicsOutcome measuresGeneral medical journalsClinical trialistsWeb-based surveyTrialistsExploratory analysisBackgroundA numberStatistical significanceSignificant differencesExternal investigatorsClinical trial data sharingTrialsMedical journalsPharmaceutical companiesFunding sourcesIndustry fundingPotential respondents
2010
Telemonitoring in Patients with Heart Failure
Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, Lin Z, Phillips CO, Hodshon BV, Cooper LS, Krumholz HM. Telemonitoring in Patients with Heart Failure. New England Journal Of Medicine 2010, 363: 2301-2309. PMID: 21080835, PMCID: PMC3237394, DOI: 10.1056/nejmoa1010029.Peer-Reviewed Original ResearchConceptsPrimary end pointUsual care groupSecondary end pointsHeart failureEnd pointHeart failure outcomesNumber of hospitalizationsTelephone-based interactive voice response systemUsual careAdverse eventsPatient's clinicianMedian ageCare groupLarge trialsInteractive voice response systemPatientsSmall studyVoice response systemNumber of daysHospitalizationReadmissionTelemonitoringSignificant differencesCliniciansDeathNational quality campaigns: who benefits?
Hansen LO, Herrin J, Nembhard IM, Busch S, Yuan CT, Krumholz HM, Bradley EH. National quality campaigns: who benefits? BMJ Quality & Safety 2010, 19: 275. PMID: 20538628, DOI: 10.1136/qshc.2009.036087.Peer-Reviewed Original Research
2009
Trial Publication after Registration in ClinicalTrials.Gov: A Cross-Sectional Analysis
Ross JS, Mulvey GK, Hines EM, Nissen SE, Krumholz HM. Trial Publication after Registration in ClinicalTrials.Gov: A Cross-Sectional Analysis. PLOS Medicine 2009, 6: e1000144. PMID: 19901971, PMCID: PMC2728480, DOI: 10.1371/journal.pmed.1000144.Peer-Reviewed Original ResearchConceptsOptional data elementsClinical trialsTrial publicationsInternet-based registryCompleteness of registrationCross-sectional analysisSelective publicationPrimary outcomeUS National LibraryReporting TrialsPublication statusTrial resultsPhase ITrialsData elementsSignificant differencesEditors' SummaryEnd dateSystematic protocolClinicalTrialsDoor-to-Balloon Times in Hospitals Within the Get-With-The-Guidelines Registry After Initiation of the Door-to-Balloon (D2B) Alliance
Nallamothu BK, Krumholz HM, Peterson ED, Pan W, Bradley E, Stern AF, Masoudi FA, Janicke DM, Hernandez AF, Cannon CP, Fonarow GC, Investigators D. Door-to-Balloon Times in Hospitals Within the Get-With-The-Guidelines Registry After Initiation of the Door-to-Balloon (D2B) Alliance. The American Journal Of Cardiology 2009, 103: 1051-1055. PMID: 19361588, DOI: 10.1016/j.amjcard.2008.12.030.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPrimary percutaneous coronary interventionD2B AlliancePercentage of patientsGWTG-CADBalloon timeST-elevation myocardial infarctionNational quality improvement effortsQuality improvement effortsBalloon (D2B) AllianceDTB timeNontransferred patientsCoronary interventionPatient characteristicsMyocardial infarctionMultivariable modelAmerican CollegePatientsDisease programsHospitalStudy periodSignificant differencesHospital performanceMinutesImprovement efforts
2006
Does Random Treatment Assignment Cause Harm to Research Participants?
Gross CP, Krumholz HM, Van Wye G, Emanuel EJ, Wendler D. Does Random Treatment Assignment Cause Harm to Research Participants? PLOS Medicine 2006, 3: e188. PMID: 16719548, PMCID: PMC1470665, DOI: 10.1371/journal.pmed.0030188.Peer-Reviewed Original ResearchConceptsClinical outcomesTreatment assignmentRCT participantsClinical trialsTrial participantsRandom treatment assignmentPrimary study outcomeMeeting eligibility criteriaImproved patient outcomesSimilar health statusSubstandard medical careBaseline characteristicsPatient groupPatient outcomesEligibility criteriaHealth outcomesHealth statusEligible manuscriptsMedical careSystematic reviewSame interventionClinical researchStudy outcomesOutcomesSignificant differences
2003
A Critical Evaluation of Critical Pathways in Head and Neck Cancer
Yueh B, Weaver EM, Bradley EH, Krumholz HM, Heagerty P, Conley A, Sasaki CT. A Critical Evaluation of Critical Pathways in Head and Neck Cancer. JAMA Otolaryngology - Head & Neck Surgery 2003, 129: 89-95. PMID: 12525201, DOI: 10.1001/archotol.129.1.89.Peer-Reviewed Original ResearchConceptsNeck cancerCritical pathwaysLaryngectomy patientsManagement of headLow-volume proceduresLinear spline regression modelsPathway adoptionObservational cohortPathway patientsContemporary cohortHistorical cohortPathway implementationMedical CenterSpline regression modelsConfounding variablesLaryngectomyPatientsUtilization trendsCohortPrior reportsIndependent impactLOSSignificant differencesCancer
1998
Admission to Hospitals With On-Site Cardiac Catheterization Facilities
Krumholz H, Chen J, Murillo J, Cohen D, Radford M. Admission to Hospitals With On-Site Cardiac Catheterization Facilities. Circulation 1998, 98: 2010-2016. PMID: 9808598, DOI: 10.1161/01.cir.98.19.2010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryCardiac Care FacilitiesCardiac CatheterizationCohort StudiesCoronary Artery BypassFemaleHealth Care CostsHospital MortalityHospitalizationHumansLength of StayMaleMedical RecordsPilot ProjectsRetrospective StudiesTime FactorsTreatment OutcomeConceptsSite cardiac catheterization facilitiesCardiac catheterization facilitiesAcute myocardial infarctionCatheterization facilitiesType of hospitalReadmission ratesCardiac proceduresMyocardial infarctionHospital costsMortality rateGood short-term clinical outcomesShort-term clinical outcomesLong-term mortality ratesAdjusted readmission ratesCardiac catheterization ratesBaseline patient characteristicsLong-term mortalityRetrospective cohort studyLower readmission ratesElderly Medicare patientsSignificant differencesCatheterization ratesRevascularization ratesCardiac catheterizationCohort study
1997
Differences in physician compensation for cardiovascular services by age, sex, and race.
Krumholz HM, Fendrick AM, Williams C, Hynes WM. Differences in physician compensation for cardiovascular services by age, sex, and race. The American Journal Of Managed Care 1997, 3: 557-63. PMID: 10169524.Peer-Reviewed Original ResearchConceptsConsecutive patientsCoronary angioplastyCardiovascular servicesPercutaneous transluminal coronary angioplastyPatients 75 yearsTransluminal coronary angioplastyPercutaneous coronary angioplastyPatients 40Patients 65Patient characteristicsPatient groupInsurance statusCardiology practicePhysiciansStress testingAngioplastySignificant differencesPatientsLower ratesSimilar differencesPhysician compensationAgeSexYearsDifferences
1995
Cholesterol and Coronary Heart Disease Risk in Elderly Patients-Reply
Krumholz H, Seeman T, de Leon C, Vaccarino V, Berkman L. Cholesterol and Coronary Heart Disease Risk in Elderly Patients-Reply. JAMA 1995, 273: 1330-1331. DOI: 10.1001/jama.1995.03520410023011.Peer-Reviewed Original ResearchLow cholesterol levelsCholesterol levelsHealth statusCoronary heart disease riskHeart disease riskOverall health statusPoor health statusAssociation of cholesterolEarly mortalityAdverse outcomesFunctional statusElderly populationPsychosocial supportPotential associationDisease riskCognitive functionPatients' repliesSocioeconomic statusCholesterol groupSignificant differencesAfrican AmericansCholesterolOnly unique featureSubstantial numberStatus