2016
Life Years Gained From Smoking-Cessation Counseling After Myocardial Infarction
Bucholz EM, Beckman AL, Kiefe CI, Krumholz HM. Life Years Gained From Smoking-Cessation Counseling After Myocardial Infarction. American Journal Of Preventive Medicine 2016, 52: 38-46. PMID: 27692757, PMCID: PMC5459385, DOI: 10.1016/j.amepre.2016.08.013.Peer-Reviewed Original ResearchConceptsSmoking cessation counselingAcute myocardial infarctionLong-term survival benefitLife yearsSurvival benefitMyocardial infarctionLife expectancyLower short-term mortalityHigher crude mortalityLong-term mortalityProspective cohort studyShort-term mortalityCooperative Cardiovascular ProjectProportional hazards modelLonger life expectancyCohort studyElderly patientsElderly smokersOlder smokersCrude mortalitySurvival differencesHospital characteristicsSmokersHazards modelLower mortality
2014
“Phenotyping” Hospital Value of Care for Patients with Heart Failure
Xu X, Li S, Lin H, Normand S, Kim N, Ott LS, Lagu T, Duan M, Kroch EA, Krumholz HM. “Phenotyping” Hospital Value of Care for Patients with Heart Failure. Health Services Research 2014, 49: 2000-2016. PMID: 24974769, PMCID: PMC4254136, DOI: 10.1111/1475-6773.12197.Peer-Reviewed Original ResearchConceptsLower mortalityHeart failureHeart failure hospitalizationHospital mortality rateLonger hospital stayIntensive care unitDistinct joint trajectoriesValue of careFailure hospitalizationHospital stayCare unitClinical outcomesGroup of hospitalsHospital characteristicsHospital careHospital patternsSurgical proceduresMultinomial logistic regressionMortality rateHigh mortalityHospitalHospitalizationMortalityLogistic regressionHospital Value
2012
Body Mass Index and Mortality in Acute Myocardial Infarction Patients
Bucholz EM, Rathore SS, Reid KJ, Jones PG, Chan PS, Rich MW, Spertus JA, Krumholz HM. Body Mass Index and Mortality in Acute Myocardial Infarction Patients. The American Journal Of Medicine 2012, 125: 796-803. PMID: 22483510, PMCID: PMC3408565, DOI: 10.1016/j.amjmed.2012.01.018.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexAcute myocardial infarctionMyocardial infarctionLower mortalityObesity paradoxMass indexAssociation of BMIMedian body mass indexCox proportional hazards regressionAcute myocardial infarction patientsImpact of obesityRegistry of patientsProportional hazards regressionMyocardial infarction patientsContinuous variablesDomains of patientsDiabetes subgroupsClinical characteristicsMultivariable adjustmentHeart failurePatient characteristicsBMI groupsDiabetes mellitusHazards regression
2009
Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study
Rathore SS, Curtis JP, Chen J, Wang Y, Nallamothu BK, Epstein AJ, Krumholz HM, Registry F. Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study. The BMJ 2009, 338: b1807. PMID: 19454739, PMCID: PMC2684578, DOI: 10.1136/bmj.b1807.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionBalloon timeCoronary interventionMyocardial infarctionCohort studyLower mortalityMultivariable logistic regression modelAssociation of doorIncremental mortality benefitProspective cohort studyNational cohort studyAcute care hospitalsLogistic regression modelsFractional polynomial modelsAdjusted riskLonger doorMedian doorMortality benefitCare hospitalOverall mortalityMAIN OUTCOMEAmerican College
2006
Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction
Foody JM, Rathore SS, Galusha D, Masoudi FA, Havranek EP, Radford MJ, Krumholz HM. Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction. Journal Of The American Geriatrics Society 2006, 54: 421-430. PMID: 16551308, PMCID: PMC2797316, DOI: 10.1111/j.1532-5415.2005.00635.x.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAged, 80 and overAtorvastatinCholesterol, LDLDrug PrescriptionsFatty Acids, MonounsaturatedFemaleFluvastatinFollow-Up StudiesHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIndolesLovastatinMaleMyocardial InfarctionOdds RatioPravastatinPyridinesPyrrolesRetrospective StudiesSurvival RateTreatment OutcomeConceptsAcute myocardial infarctionHydroxymethylglutaryl-CoA reductase inhibitorsStatin therapyMyocardial infarctionLower mortalityOlder personsReductase inhibitorsPrincipal discharge diagnosisAcute care hospitalsCause mortalityEligible patientsOlder patientsYounger patientsCare hospitalDischarge prescriptionsPrimary outcomeDischarge diagnosisHospital characteristicsEfficacy dataMedicare patientsMultivariable modelObservational studyPatientsStatinsDischarge statins
2005
Prior Aspirin Use and Outcomes in Elderly Patients Hospitalized With Acute Myocardial Infarction
Portnay EL, Foody JM, Rathore SS, Wang Y, Masoudi FA, Curtis JP, Krumholz HM. Prior Aspirin Use and Outcomes in Elderly Patients Hospitalized With Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2005, 46: 967-974. PMID: 16168277, PMCID: PMC2790536, DOI: 10.1016/j.jacc.2005.06.049.Peer-Reviewed Original ResearchConceptsPrior aspirin useCondition-specific readmissionAspirin useMyocardial infarctionCause readmissionMedicare beneficiariesSix-month mortalityAcute myocardial infarctionElderly patientsMultivariable adjustmentPrognostic significanceHigh riskReadmissionLower riskLower mortalityPatientsOne monthMortalityMonthsInfarctionOne-thirdNational sampleRiskMarkersAssociation
2004
National Patterns of Use and Effectiveness of Angiotensin-Converting Enzyme Inhibitors in Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction
Masoudi FA, Rathore SS, Wang Y, Havranek EP, Curtis JP, Foody JM, Krumholz HM. National Patterns of Use and Effectiveness of Angiotensin-Converting Enzyme Inhibitors in Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction. Circulation 2004, 110: 724-731. PMID: 15289383, DOI: 10.1161/01.cir.0000138934.28340.ed.Peer-Reviewed Original ResearchConceptsACE inhibitor prescriptionAngiotensin receptor blockersVentricular systolic dysfunctionHeart failureACE inhibitorsInhibitor prescriptionSystolic dysfunctionOlder patientsLeft ventricular systolic dysfunctionAngiotensin converting enzyme (ACE) inhibitorsSerum creatinine levelsACE inhibitor useCreatinine levelsHospital factorsInhibitor useReceptor blockersSerum creatininePatient genderClinical trialsTherapeutic substitutionLower riskEnzyme inhibitorsLower mortalityPatientsSecondary analysis
2001
Angiotensin-converting enzyme inhibitor dosages in elderly patients with heart failure
Chen Y, Wang Y, Radford M, Krumholz H. Angiotensin-converting enzyme inhibitor dosages in elderly patients with heart failure. American Heart Journal 2001, 141: 410-417. PMID: 11231438, DOI: 10.1067/mhj.2001.113227.Peer-Reviewed Original ResearchConceptsACE inhibitorsHeart failureClinical trialsSystolic dysfunctionElderly patientsLow dosesConfirmed heart failureDosage of angiotensinRepresentative elderly cohortDose-response relationshipHospital dischargeClinical factorsGuideline recommendationsElderly cohortMedication dataMedical recordsAdministrative databasesConnecticut hospitalsPractice guidelinesEnzyme inhibitorsPatientsLower mortalityHigh dosesDosesMortalityAspirin and the Treatment of Heart Failure in the Elderly
Krumholz HM, Chen YT, Radford MJ. Aspirin and the Treatment of Heart Failure in the Elderly. JAMA Internal Medicine 2001, 161: 577-582. PMID: 11252118, DOI: 10.1001/archinte.161.4.577.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHeart failureArtery diseaseBenefits of aspirinPatients 65 yearsRetrospective cohort studyUse of aspirinGroup of patientsAspirin prescriptionAspirin therapyCohort studyDischarge medicationsOlder patientsPatient characteristicsRandomized trialsVascular diseaseTreatment characteristicsConnecticut hospitalsBaseline differencesAspirinPatientsLower mortalityStrong associationDiseaseStudy sample
2000
Thrombolytic therapy in older patients
Berger A, Radford M, Wang Y, Krumholz H. Thrombolytic therapy in older patients. Journal Of The American College Of Cardiology 2000, 36: 366-374. PMID: 10933344, DOI: 10.1016/s0735-1097(00)00723-3.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrimary angioplastyThrombolytic therapyOlder patientsBundle branch blockAcute reperfusionBranch blockST-segment elevationPatients age 65Population-based cohortReperfusion strategyReperfusion therapyHospital arrivalSurvival benefitSymptom onsetSegment elevationPhysician factorsST elevationMyocardial infarctionNational cohortAngioplastyBetter survivalMedicare beneficiariesLower mortalityPatients