2008
Prevention of Heart Failure
Schocken DD, Benjamin EJ, Fonarow GC, Krumholz HM, Levy D, Mensah GA, Narula J, Shor ES, Young JB, Hong Y. Prevention of Heart Failure. Circulation 2008, 117: 2544-2565. PMID: 18391114, DOI: 10.1161/circulationaha.107.188965.Peer-Reviewed Original ResearchConceptsPrevention of HFChronic kidney diseaseCoronary heart diseaseKidney diseaseHeart diseaseRisk factorsAsymptomatic left ventricular systolic dysfunctionLeft ventricular systolic dysfunctionLeft ventricular systolic functionHF prevention strategiesVentricular systolic dysfunctionVentricular systolic functionHeart failure ratesDevelopment of HFNational awareness campaignGenetic risk factorsEvidence-based managementSystolic dysfunctionSystolic functionHeart failurePatient groupPathophysiological basisPrevention strategiesDiseaseEarly detection
2005
Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project
Rathore SS, Foody JM, Wang Y, Herrin J, Masoudi FA, Havranek EP, Ordin DL, Krumholz HM. Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project. American Heart Journal 2005, 149: 121-128. PMID: 15660043, PMCID: PMC2790278, DOI: 10.1016/j.ahj.2004.06.008.Peer-Reviewed Original ResearchConceptsAngiotensin receptor blockersNational Heart Failure ProjectLeft ventricular systolic functionQuality of careACE inhibitor prescriptionHeart Failure ProjectService Medicare patientsHeart failureInhibitor prescriptionMedicare patientsMultivariable hierarchical logistic regression modelsLower crude ratesPrescription of angiotensinLeft ventricular dysfunctionVentricular systolic functionYear of admissionHierarchical logistic regression modelsLower mortality rateLogistic regression modelsSex differencesLow overall rateMultivariable adjustmentVentricular dysfunctionElderly patientsReceptor blockers
2003
Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure
Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF, Ordin DL, Krumholz HM. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. American Heart Journal 2003, 146: 250-257. PMID: 12891192, DOI: 10.1016/s0002-8703(03)00189-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsCross-Sectional StudiesFemaleHeart FailureHospitalizationHumansMaleMineralocorticoid Receptor AntagonistsPatient SelectionRandomized Controlled Trials as TopicSpironolactoneUnited StatesVentricular Dysfunction, LeftConceptsLeft ventricular systolic functionVentricular systolic functionHeart failureEnrollment criteriaClinical trialsOlder personsSystolic functionRandomized Aldactone Evaluation Study (RALES) trialHospitalized older personsRandomized Intervention TrialTrials of agentsLeft ventricular dysfunctionCongestive heart failureHeart failure patientsAcute care hospitalsCross-sectional studySubgroups of ageCommunity-based practiceTrial eligibilityVentricular dysfunctionFailure patientsOlder patientsCare hospitalMERIT-HFTrial populationLeft ventricular systolic function and survival in a contemporary cohort of patients with heart failure
Masoudi F, Wolfe P, Rathore S, Foody J, Ordin D, Krumholz H, Havranek E. Left ventricular systolic function and survival in a contemporary cohort of patients with heart failure. Journal Of The American College Of Cardiology 2003, 41: 147-148. DOI: 10.1016/s0735-1097(03)80852-5.Peer-Reviewed Original ResearchLeft ventricular systolic functionVentricular systolic functionSystolic functionHeart failureContemporary cohortPatientsCohortAssociation of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure. JAMA 2003, 289: 871-878. PMID: 12588271, DOI: 10.1001/jama.289.7.871.Peer-Reviewed Original ResearchConceptsSerum digoxin concentrationHigh serum digoxin concentrationsLeft ventricular ejection fractionVentricular ejection fractionHeart failureMortality rateDIG trialDigoxin therapyEjection fractionDigoxin concentrationsDepressed left ventricular systolic functionDigitalis Investigation Group trialHigher absolute mortality rateLeft ventricular systolic functionOverall mortality benefitVentricular systolic functionCause mortality ratesAbsolute mortality ratesLower mortality rateCause mortalityMultivariable adjustmentMortality benefitSystolic functionClinical outcomesSerum concentrationsGender, age, and heart failure with preserved left ventricular systolic function
Masoudi FA, Havranek EP, Smith G, Fish RH, Steiner JF, Ordin DL, Krumholz HM. Gender, age, and heart failure with preserved left ventricular systolic function. Journal Of The American College Of Cardiology 2003, 41: 217-223. PMID: 12535812, DOI: 10.1016/s0735-1097(02)02696-7.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic functionImpaired left ventricular systolic functionVentricular systolic functionHeart failureSystolic functionFemale genderDiagnosis of HFMedical chart abstractionCoronary artery diseasePrincipal discharge diagnosisAge 65 yearsMultivariable logistic regressionCross-sectional studyPotential confounding variablesRenal insufficiencyChart abstractionClinical characteristicsElderly patientsArtery diseaseEjection fractionPulmonary diseasePatient factorsAtrial fibrillationDischarge diagnosisPotential confounders
2002
Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure
Rathore SS, Wang Y, Krumholz HM. Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure. New England Journal Of Medicine 2002, 347: 1403-1411. PMID: 12409542, DOI: 10.1056/nejmoa021266.Peer-Reviewed Original ResearchConceptsEffect of digoxinDepressed left ventricular systolic functionLeft ventricular systolic functionVentricular systolic functionSex-based differencesRate of deathDigoxin therapyHeart failureSystolic functionMultivariable Cox proportional hazards modelsDigitalis Investigation Group (DIG) studyDigitalis Investigation Group trialCox proportional hazards modelHeart failure variesPrimary end pointRisk of deathProportional hazards modelMantel-Haenszel testOverall mortalityTherapy differsEpidemiologic featuresMultivariable analysisClinical variablesSubgroup analysisGroup trialsSpectrum of heart failure in older patients: Results from the national heart failure project
Havranek EP, Masoudi FA, Westfall KA, Wolfe P, Ordin DL, Krumholz HM. Spectrum of heart failure in older patients: Results from the national heart failure project. American Heart Journal 2002, 143: 412-417. PMID: 11868045, DOI: 10.1067/mhj.2002.120773.Peer-Reviewed Original ResearchConceptsLong-term care facilitiesHeart failureCare facilitiesElderly patientsClinical trialsNational Heart Failure ProjectLeft ventricular ejection fractionLeft ventricular systolic functionChronic obstructive pulmonary diseaseAssociated laboratory abnormalitiesHeart Failure ProjectHistory of hypertensionPoor renal functionThird of patientsVentricular systolic functionMajority of patientsMultiple comorbid conditionsObstructive pulmonary diseaseVentricular ejection fractionExclusion of patientsLong-term hemodialysisCoronary heart diseasePopulation-based studyAcute care facilitiesEvidence-based guidance
1999
Sex differences in the clinical care and outcomes of congestive heart failure in the elderly
Vaccarino V, Chen Y, Wang Y, Radford M, Krumholz H. Sex differences in the clinical care and outcomes of congestive heart failure in the elderly. American Heart Journal 1999, 138: 835-842. PMID: 10539813, DOI: 10.1016/s0002-8703(99)70007-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsAspirinBlood PressureCardiac CatheterizationConnecticutCoronary AngiographyDiureticsDrug Therapy, CombinationFemaleFollow-Up StudiesHeart FailureHumansMaleMyocardial RevascularizationPatient ReadmissionPlatelet Aggregation InhibitorsRetrospective StudiesSeverity of Illness IndexSex CharacteristicsStroke VolumeSurvival RateTreatment OutcomeConceptsHistory of hypertensionSystolic blood pressureHeart failureMortality rateBlood pressureHeart diseaseHigher systolic blood pressureLeft ventricular systolic functionSex differencesPrevious coronary heart diseaseSimilar hospital coursesVentricular systolic functionCongestive heart failureIschemic heart diseaseCoronary heart diseaseHospital courseElderly patientsReadmission ratesRehospitalization ratesSystolic functionMale patientsVentricular functionACE inhibitorsMultivariable analysisTreatment patterns
1997
Quality of Care for Elderly Patients Hospitalized With Heart Failure
Krumholz HM, Wang Y, Parent EM, Mockalis J, Petrillo M, Radford MJ. Quality of Care for Elderly Patients Hospitalized With Heart Failure. JAMA Internal Medicine 1997, 157: 2242-2247. PMID: 9343001, DOI: 10.1001/archinte.1997.00440400092011.Peer-Reviewed Original ResearchConceptsHeart failureQuality of careEnzyme inhibitorsElderly patientsClinical practiceResearch Clinical Practice GuidelinesLeft ventricular ejection fractionLeft ventricular systolic functionRetrospective medical record reviewAngiotensin-converting enzyme inhibitorSevere aortic stenosisPercentage of patientsVentricular systolic functionMedical record reviewVentricular ejection fractionClinical practice guidelinesPrincipal discharge diagnosisAcute care hospitalsActual clinical practiceHealth care policyChart reviewSystolic functionAortic stenosisAppropriate patientsCare hospital