2014
Trends in Use of Ezetimibe After the ENHANCE Trial, 2007 Through 2010
Ross JS, Frazee SG, Garavaglia SB, Levin R, Novshadian H, Jackevicius CA, Stettin G, Krumholz HM. Trends in Use of Ezetimibe After the ENHANCE Trial, 2007 Through 2010. JAMA Internal Medicine 2014, 174: 1486-1493. PMID: 25070672, PMCID: PMC4208827, DOI: 10.1001/jamainternmed.2014.3404.Peer-Reviewed Original ResearchConceptsLipid-lowering agentsENHANCE trialEzetimibe useEzetimibe initiationPharmacy benefit managersUse of ezetimibeProgression of atherosclerosisAdults 18 yearsHalf of adultsAtherosclerosis regression trialsPredictors of useBenefit managersEzetimibe monotherapyMonotherapy usersMedication initiationEligible adultsPrescription claimsCholesterol levelsRetrospective analysisMAIN OUTCOMEAdult beneficiariesUS census divisionsDiscontinuationRegression trialsEzetimibe
2011
Statin Use in Outpatients With Obstructive Coronary Artery Disease
Arnold SV, Spertus JA, Tang F, Krumholz HM, Borden WB, Farmer SA, Ting HH, Chan PS. Statin Use in Outpatients With Obstructive Coronary Artery Disease. Circulation 2011, 124: 2405-2410. PMID: 22064595, PMCID: PMC3527107, DOI: 10.1161/circulationaha.111.038265.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArterial Occlusive DiseasesCardiovascular DiseasesCholesterol, LDLCoronary Artery DiseaseFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedOutpatientsPractice Guidelines as TopicProspective StudiesRegistriesRetrospective StudiesRisk FactorsTreatment OutcomeConceptsObstructive coronary artery diseaseLow-density lipoprotein cholesterol levelsCoronary artery diseaseLipoprotein cholesterol levelsLipid-lowering therapyCholesterol levelsStatin therapyUntreated patientsStatin treatmentArtery diseaseLow-density lipoprotein cholesterol valuesNonstatin lipid-lowering medicationsRobust clinical trial evidenceRecent coronary revascularizationClinical trial evidenceLipid-lowering medicationsRoutine outpatient careLipoprotein cholesterol valuesRate of treatmentNonstatin medicationsNonstatin therapiesOutpatient registryCardiovascular morbidityCoronary revascularizationLipid management
2006
Statins and Mortality Among Elderly Patients Hospitalized With Heart Failure
Foody JM, Shah R, Galusha D, Masoudi FA, Havranek EP, Krumholz HM. Statins and Mortality Among Elderly Patients Hospitalized With Heart Failure. Circulation 2006, 113: 1086-1092. PMID: 16490817, DOI: 10.1161/circulationaha.105.591446.Peer-Reviewed Original ResearchConceptsHeart failureStatin therapyElderly patientsOlder patientsCoronary artery disease statusCox proportional hazards modelCurrent HF therapiesLong-term mortalityPrimary discharge diagnosisGroup of patientsTotal cholesterol levelsRandomized clinical trialsEligible Medicare beneficiariesProportional hazards modelYears of ageHF therapyStatin useClinical characteristicsDischarge diagnosisCholesterol levelsHospital characteristicsClinical trialsPhysician specialtyTeaching hospitalStatins
2005
Knowledge of Cholesterol Levels and Targets in Patients With Coronary Artery Disease
Cheng S, Lichtman JH, Amatruda JM, Smith GL, Mattera JA, Roumanis SA, Krumholz HM. Knowledge of Cholesterol Levels and Targets in Patients With Coronary Artery Disease. Preventive Cardiology 2005, 8: 11-17. PMID: 15722689, DOI: 10.1111/j.1520-037x.2005.3939.x.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHigh-density lipoproteinLow-density lipoproteinCholesterol targetsArtery diseaseCholesterol levelsMultiple cardiac risk factorsCardiac risk factorsTotal cholesterol levelsTotal cholesterol valuesRisk factorsCardiovascular diseaseCholesterol valuesPrevious historyPatientsLipoproteinDiseaseCollege educationWomenNonwhitesEducation effortsNational targetsTargetCholesterol
2004
Clinical trial of an educational intervention to achieve recommended cholesterol levels in patients with coronary artery disease
Lichtman JH, Amatruda J, Yaari S, Cheng S, Smith GL, Mattera JA, Roumanis SA, Wang Y, Radford MJ, Krumholz HM. Clinical trial of an educational intervention to achieve recommended cholesterol levels in patients with coronary artery disease. American Heart Journal 2004, 147: 522-528. PMID: 14999204, DOI: 10.1016/j.ahj.2003.06.003.Peer-Reviewed Original ResearchConceptsLDL cholesterol target levelsCholesterol target levelsProportion of patientsCoronary artery diseaseUsual care groupArtery diseaseLevels 1 yearCholesterol managementCare groupEducational interventionPatient knowledgeLow-density lipoprotein cholesterol (LDL-C) target levelsTarget levelCholesterol knowledgeUsual careClinical characteristicsSecondary outcomesPrimary outcomeCholesterol levelsClinical trialsIntervention groupPatientsHospitalizationDiseaseIntervention
2003
Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint
Foody JM, Krumholz HM. Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint. The American Journal Of Geriatric Cardiology 2003, 12: 357-360. PMID: 14610384, DOI: 10.1111/j.1076-7460.2003.02912.x.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePrimary preventionArtery diseaseOvert coronary artery diseaseRisk of myositisCardiovascular disease eventsRole of statinsUse of statinsAge 65 yearsBalance of risksCardiovascular eventsStatin therapyPatient preferencesCholesterol levelsCardiovascular diseaseOctogenariansClinical uncertaintyDisease eventsCurrent evidenceStatinsAge groupsDiseasePreventionRiskMyositisLong‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project
Foody JM, Wang Y, Kiefe CI, Ellerbeck EF, Gold J, Radford MJ, Krumholz HM. Long‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project. Journal Of The American Geriatrics Society 2003, 51: 930-936. PMID: 12834512, DOI: 10.1046/j.1365-2389.2003.51305.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal serum cholesterolElevated total serum cholesterolCoronary artery diseaseCause mortalityTotal cholesterolSerum cholesterolElderly survivorsPrognostic importanceMyocardial infarctionCholesterol levelsLong-term prognostic importanceRetrospective medical record reviewAdjusted hazard ratioMedical record reviewLower total cholesterolStudy inclusion criteriaYear of dischargePrimary endpointOlder patientsArtery diseaseHazard ratioRecord reviewAcute careLipid subfractions
2001
Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension
Abramson J, Berger A, Krumholz HM, Vaccarino V. Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension. JAMA Internal Medicine 2001, 161: 1725-1730. PMID: 11485505, DOI: 10.1001/archinte.161.14.1725.Peer-Reviewed Original ResearchConceptsHeart failureSystolic hypertensionMyocardial infarctionDepressed personsOlder personsCox proportional hazards regressionEpidemiological Studies Depression ScaleIsolated systolic hypertensionIncident heart failureCoronary heart diseaseProportional hazards regressionBlood pressureElectrocardiographic abnormalitiesHazards regressionElderly ProgramCholesterol levelsHeart diseaseRisk factorsNondepressed personsDepression ScaleAdditional adjustmentElevated riskHigh riskTreatment groupsHypertension
1995
Cholesterol and Coronary Heart Disease Risk in Elderly Patients-Reply
Krumholz H, Seeman T, de Leon C, Vaccarino V, Berkman L. Cholesterol and Coronary Heart Disease Risk in Elderly Patients-Reply. JAMA 1995, 273: 1330-1331. DOI: 10.1001/jama.1995.03520410023011.Peer-Reviewed Original ResearchLow cholesterol levelsCholesterol levelsHealth statusCoronary heart disease riskHeart disease riskOverall health statusPoor health statusAssociation of cholesterolEarly mortalityAdverse outcomesFunctional statusElderly populationPsychosocial supportPotential associationDisease riskCognitive functionPatients' repliesSocioeconomic statusCholesterol groupSignificant differencesAfrican AmericansCholesterolOnly unique featureSubstantial numberStatus
1994
Lack of Association Between Cholesterol and Coronary Heart Disease Mortality and Morbidity and All-Cause Mortality in Persons Older Than 70 Years
Krumholz HM, Seeman TE, Merrill SS, Mendes de Leon CF, Vaccarino V, Silverman DI, Tsukahara R, Ostfeld AM, Berkman LF. Lack of Association Between Cholesterol and Coronary Heart Disease Mortality and Morbidity and All-Cause Mortality in Persons Older Than 70 Years. JAMA 1994, 272: 1335-1340. PMID: 7772105, DOI: 10.1001/jama.1994.03520170045034.Peer-Reviewed Original ResearchConceptsCoronary heart disease mortalityHeart disease mortalityTotal serum cholesterolSerum cholesterol levelsRisk factor-adjusted odds ratioFactor-adjusted odds ratiosTotal serum cholesterol levelsCause mortalityCoronary heart diseaseHDL-C levelsUnstable anginaHighest tertileCholesterol levelsSerum cholesterolMyocardial infarctionDisease mortalityLow HDLLowest tertileHeart diseaseRisk factorsOdds ratioElevated total serum cholesterol levelsHigher total serum cholesterolCommunity-based cohort studyHigh-density lipoprotein cholesterol