Featured Publications
Estimating deaths averted and cost per life saved by scaling up mRNA COVID-19 vaccination in low-income and lower-middle-income countries in the COVID-19 Omicron variant era: a modelling study
Savinkina A, Bilinski A, Fitzpatrick M, Paltiel AD, Rizvi Z, Salomon J, Thornhill T, Gonsalves G. Estimating deaths averted and cost per life saved by scaling up mRNA COVID-19 vaccination in low-income and lower-middle-income countries in the COVID-19 Omicron variant era: a modelling study. BMJ Open 2022, 12: e061752. PMID: 36100306, PMCID: PMC9471205, DOI: 10.1136/bmjopen-2022-061752.Peer-Reviewed Original ResearchConceptsLow-income countriesIncome countriesDeath avertedHigh-income nationsStatistical lifeAvertable deathsIncome nationsCOVID-19 deathsReasonable investmentHigh costKey inputCountriesParameter estimatesAvertedCostSensitivity analysisUniversal vaccinationGlobal vaccinationMRNA COVID-19 vaccinationNationsInvestmentPrimary vaccine seriesLow vaccine effectivenessCOVID-19 vaccinationPublic dataSurveillance for endemic infectious disease outbreaks: Adaptive sampling using profile likelihood estimation
Fairley M, Rao IJ, Brandeau ML, Qian GL, Gonsalves GS. Surveillance for endemic infectious disease outbreaks: Adaptive sampling using profile likelihood estimation. Statistics In Medicine 2022, 41: 3336-3348. PMID: 35527474, PMCID: PMC9283243, DOI: 10.1002/sim.9420.Peer-Reviewed Original Research
2024
Comparing frequency of booster vaccination to prevent severe COVID-19 by risk group in the United States
Park H, Gonsalves G, Tan S, Kelly J, Rutherford G, Wachter R, Schechter R, Paltiel A, Lo N. Comparing frequency of booster vaccination to prevent severe COVID-19 by risk group in the United States. Nature Communications 2024, 15: 1883. PMID: 38448400, PMCID: PMC10917753, DOI: 10.1038/s41467-024-45549-9.Peer-Reviewed Original ResearchConceptsSevere COVID-19Risk of severe COVID-19COVID-19 booster vaccinationBooster vaccinationHigh-risk populationAbsolute annual riskWaning of protectionImmunocompromised populationsFrequent boostingOlder age groupsAnnual boosterImmune evasionImmunocompromised personsPublic health needsPublic health guidanceRisk groupsFrequent boostersImmune statusRisk factorsFrequency of booster vaccinationHealth needsHealth guidanceCompare frequenciesAge groupsVaccineAccessibility of Opioid Treatment Programs Based on Conventional vs Perceived Travel Time Measures
Kim J, Lee J, Thornhill T, Dennett J, Lu H, Howell B, Grau L, Fiellin D, Heimer R, Gonsalves G. Accessibility of Opioid Treatment Programs Based on Conventional vs Perceived Travel Time Measures. JAMA Network Open 2024, 7: e240209. PMID: 38376839, PMCID: PMC10879949, DOI: 10.1001/jamanetworkopen.2024.0209.Peer-Reviewed Original ResearchConceptsTransit travel timeAccessibility metricsTravel timeTravel componentsAccessibility scoresTransportation burdenTravel burdenOut-of-vehicleComponents of travelConventional accessibility measuresSpatial regression modelsTravel time measurementsPublic transitTransit schedulesAccessibility measuresDeparture timeTravel time analysisTrip durationTravelOperating hoursTime analysisCross-sectional studyOpioid use disorderPolicy recommendationsDecision-making
2023
Clade I–Associated Mpox Cases Associated with Sexual Contact, the Democratic Republic of the Congo - Volume 30, Number 1—January 2024 - Emerging Infectious Diseases journal - CDC
Kibungu E, Vakaniaki E, Kinganda-Lusamaki E, Kalonji-Mukendi T, Pukuta E, Hoff N, Bogoch I, Cevik M, Gonsalves G, Hensley L, Low N, Shaw S, Schillberg E, Hunter M, Lunyanga L, Linsuke S, Madinga J, Peeters M, Cigolo J, Ahuka-Mundeke S, Muyembe J, Rimoin A, Kindrachuk J, Mbala-Kingebeni P, Lushima R, Consortium I. Clade I–Associated Mpox Cases Associated with Sexual Contact, the Democratic Republic of the Congo - Volume 30, Number 1—January 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 30: 172-176. PMID: 38019211, PMCID: PMC10756366, DOI: 10.3201/eid3001.231164.Peer-Reviewed Original ResearchMortality, incarceration and cost implications of fentanyl felonization laws: A modeling study
Savinkina A, Jurecka C, Gonsalves G, Barocas J. Mortality, incarceration and cost implications of fentanyl felonization laws: A modeling study. International Journal Of Drug Policy 2023, 121: 104175. PMID: 37729682, PMCID: PMC10840895, DOI: 10.1016/j.drugpo.2023.104175.Peer-Reviewed Original ResearchOutbreaks in U.S. Migrant Detention Centers — A Vaccine-Preventable Cause of Health Inequity
Lo N, Gonsalves G. Outbreaks in U.S. Migrant Detention Centers — A Vaccine-Preventable Cause of Health Inequity. New England Journal Of Medicine 2023, 389: 679-681. PMID: 37602574, DOI: 10.1056/nejmp2304716.Peer-Reviewed Original ResearchUsing Bandit Algorithms to Maximize SARS-CoV-2 Case-Finding: Evaluation and Feasibility Study
Rayo M, Faulkner D, Kline D, Thornhill T, Malloy S, Della Vella D, Morey D, Zhang N, Gonsalves G. Using Bandit Algorithms to Maximize SARS-CoV-2 Case-Finding: Evaluation and Feasibility Study. JMIR Public Health And Surveillance 2023, 9: e39754. PMID: 37581924, PMCID: PMC10430782, DOI: 10.2196/39754.Peer-Reviewed Original ResearchConceptsSARS-CoV-2COVID-19 annual update: a narrative review
Biancolella M, Colona V, Luzzatto L, Watt J, Mattiuz G, Conticello S, Kaminski N, Mehrian-Shai R, Ko A, Gonsalves G, Vasiliou V, Novelli G, Reichardt J. COVID-19 annual update: a narrative review. Human Genomics 2023, 17: 68. PMID: 37488607, PMCID: PMC10367267, DOI: 10.1186/s40246-023-00515-2.Peer-Reviewed Original ResearchEarly OxyContin Marketing Linked To Long-Term Spread Of Infectious Diseases Associated With Injection Drug Use
Dennett J, Gonsalves G. Early OxyContin Marketing Linked To Long-Term Spread Of Infectious Diseases Associated With Injection Drug Use. Health Affairs 2023, 42: 1081-1090. PMID: 37467441, PMCID: PMC10521060, DOI: 10.1377/hlthaff.2023.00146.Peer-Reviewed Original ResearchConceptsInjection drug useDrug useAdverse long-term outcomesInfectious diseasesReformulation of OxyContinAcute hepatitis ALong-term outcomesOpioid-related overdosesInitial marketingFatal drug overdosesBacterial complicationsHepatitis ADrug overdosesEffects of exposureOpioid epidemicViral infectionGreater burdenIllicit drugsLow exposureComplicationsHigh exposureOverdosesOutcomesDiseaseOxyContinPopulation-Level Health Effects of Involuntary Displacement of People Experiencing Unsheltered Homelessness Who Inject Drugs in US Cities
Barocas J, Nall S, Axelrath S, Pladsen C, Boyer A, Kral A, Meehan A, Savinkina A, Peery D, Bien M, Agnew-Brune C, Goldshear J, Chiang J, Linas B, Gonsalves G, Bluthenthal R, Mosites E, Wortley P, Todd J, Melton D, Flynn C, German D, Klevens M, Doherty R, O'Cleirigh C, Jimenez A, Clyde T, Poe J, Vaaler M, Deng J, Al-Tayyib A, Shodell D, Higgins E, Griffin V, Sanger C, Khuwaja S, Lopez Z, Padgett P, Kwa Sey E, Ma Y, Santacruz H, Brantley M, Mathews C, Marr J, Spencer E, Nixon W, Forrest D, Anderson B, Tate A, Abrego M, Robinson W, Barak N, Beckford J, Braunstein S, Rivera A, Carrillo S, Ibrahim A, Wogayehu A, Moraga L, Brady K, Shinefeld J, Nnumolu C, Menza T, Orellana E, Bhattari A, Flynn A, Chambers O, Ramos M, McFarland W, Lin J, Miller D, Miranda De Leon S, Rolon-Colon Y, Martinez M, Jaenicke T, Glick S, Kienzle J, Smith B, Reid T, Opoku J, Kuo I, Adams M, Baugher A, Broz D, Burnett J, Chambers S, Chapin-Bardales J, Denning P, Finlayson T, Handanagic S, Hickey T, Kanny D, Lee K, Lewis R, Morris E, Olansky E, Robbins T, Sionean C, Smith A, Teplinskaya A, Trujillo K, Wejnert C, Whiteman A, Xia M. Population-Level Health Effects of Involuntary Displacement of People Experiencing Unsheltered Homelessness Who Inject Drugs in US Cities. JAMA 2023, 329: 1478-1486. PMID: 37036716, PMCID: PMC10087093, DOI: 10.1001/jama.2023.4800.Peer-Reviewed Original ResearchConceptsNational HIV Behavioral Surveillance SystemInitiation of medicationInjection-related infectionsOpioid use disorderUse disordersHealth effectsInjection drug useLong-term health effectsDrug-related morbidityPopulation attributable fractionBehavioral Surveillance SystemSubstance use disordersMAIN OUTCOMEOverdose deathsRepresentative cohortAdditional deathsOverdose mortalityHealth outcomesDrug useNatural historyDisease controlMortalityDisorder outcomesDrugsHealth implicationsPatterns of Infectious Disease Associated With Injection Drug Use in Massachusetts
Gonsalves G, Paltiel A, Thornhill T, DeMaria A, Cranston K, Klevens R, Warren J. Patterns of Infectious Disease Associated With Injection Drug Use in Massachusetts. Clinical Infectious Diseases 2023, 76: 2134-2139. PMID: 36757712, PMCID: PMC10273381, DOI: 10.1093/cid/ciad073.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsHuman immunodeficiency virusHepatitis C virusInjection drug useHCV casesInfective endocarditisHIV casesDrug useSubstance use disordersLogistic regression modelsClinical sequalaeSSTI casesPublic health crisisTissue infectionsImmunodeficiency virusDisease AssociatedHIV outbreakAbscess incisionC virusUse disordersInfectious diseasesInfectionMultiple outbreaksMedical proceduresSuch associationsPlanning for Mpox on a College Campus: A Model-Based Decision-Support Tool.
Savinkina A, Chitwood M, Kwon J, Pitzer V, Gonsalves G, Paltiel A. Planning for Mpox on a College Campus: A Model-Based Decision-Support Tool. Annals Of Internal Medicine 2023, 176: 340-347. PMID: 36716454, PMCID: PMC10338074, DOI: 10.7326/m22-2734.Peer-Reviewed Original ResearchConceptsSustained transmissionNational InstituteLow-risk groupHigh-risk populationPopulation of MSMHealth-National InstituteResidential college campusSymptomatic casesHypothetical cohortCongregate settingsStudy populationPreemptive vaccinationReactive vaccinationInfectious diseasesVaccinationDrug abuseBasic reproductive numberFuture outbreaksFrequent physical contactMSMReproductive numberOutbreakDaysMenTimely detectionGeographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009–2019
Lu H, Crawford F, Gonsalves G, Grau L. Geographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009–2019. Annals Of Epidemiology 2023, 79: 32-38. PMID: 36669599, PMCID: PMC10163838, DOI: 10.1016/j.annepidem.2023.01.009.Peer-Reviewed Original ResearchEstimated Testing, Tracing, and Vaccination Targets for Containment of the US Mpox Outbreak
Chitwood M, Kwon J, Savinkina A, Walker J, Bilinski A, Gonsalves G. Estimated Testing, Tracing, and Vaccination Targets for Containment of the US Mpox Outbreak. JAMA Network Open 2023, 6: e2250984. PMID: 36637825, PMCID: PMC9857202, DOI: 10.1001/jamanetworkopen.2022.50984.Peer-Reviewed Original Research
2022
Prioritization of carceral spending in U.S. cities: Development of the Carceral Resource Index (CRI) and the role of race and income inequality
Skaathun B, Maviglia F, Vo A, McBride A, Seymour S, Mendez S, Gonsalves G, Beletsky L. Prioritization of carceral spending in U.S. cities: Development of the Carceral Resource Index (CRI) and the role of race and income inequality. PLOS ONE 2022, 17: e0276818. PMID: 36520883, PMCID: PMC9754598, DOI: 10.1371/journal.pone.0276818.Peer-Reviewed Original ResearchConceptsCarceral systemRole of raceU.S. citiesLarge U.S. citiesTerms of incomeSocial supportCarceral institutionsStructural racismBudgetary prioritiesEconomic disparitiesEthnic compositionBudget prioritiesGovernment investmentBlack residentsWhite residentsPopulation concentrationSocial conflict modelIncome inequalityBudgetary investmentsEconomic profileInvestment prioritiesSupportive servicesConflict modelStrong prioritizationResource indexMonkeypox, COVID-19, AIDS: have we progressed so little?
Gonsalves G. Monkeypox, COVID-19, AIDS: have we progressed so little? Nature 2022, 609: 443-443. PMID: 36100678, DOI: 10.1038/d41586-022-02917-z.Peer-Reviewed Original ResearchConceptsFailure of technologyMonkeypox Emergency: Urgent Questions and Perspectives
Rothenburg S, Yang Z, Beard P, Sawyer S, Titanji B, Gonsalves G, Kindrachuk J. Monkeypox Emergency: Urgent Questions and Perspectives. Cell 2022, 185: 3279-3281. PMID: 35998628, PMCID: PMC9395144, DOI: 10.1016/j.cell.2022.08.002.Peer-Reviewed Original ResearchDéjà vu All Over Again? Emergent Monkeypox, Delayed Responses, and Stigmatized Populations
Gonsalves GS, Mayer K, Beyrer C. Déjà vu All Over Again? Emergent Monkeypox, Delayed Responses, and Stigmatized Populations. Journal Of Urban Health 2022, 99: 603-606. PMID: 35916973, PMCID: PMC9345008, DOI: 10.1007/s11524-022-00671-1.Commentaries, Editorials and LettersHumansMonkeypoxEnd COVID-19 in low- and middle-income countries
Mobarak AM, Miguel E, Abaluck J, Ahuja A, Alsan M, Banerjee A, Breza E, Chandrasekhar AG, Duflo E, Dzansi J, Garrett D, Goldsmith-Pinkham P, Gonsalves GS, Hossain MM, Jakubowski A, Kang G, Kharel A, Kremer M, Meriggi N, Nekesa C, Olken BA, Omer SB, Qadri F, Rees H, Salako B, Voors M, Warren S, Więcek W. End COVID-19 in low- and middle-income countries. Science 2022, 375: 1105-1110. PMID: 35271319, DOI: 10.1126/science.abo4089.Commentaries, Editorials and Letters