2021
Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles
Rothman D, De Feyter H, Mason G, de Graaf R, Hyder F, Behar K. Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles. 2021, 688-700. DOI: 10.1016/b978-0-12-819460-7.00341-8.Chapters
2020
1772-P: Reversibility of Altered Brain Glucose Kinetics in T2DM
RANGEL E, GUNAWAN F, JIANG L, SAVOYE M, DAI F, ROTHMAN D, MASON G, HWANG J. 1772-P: Reversibility of Altered Brain Glucose Kinetics in T2DM. Diabetes 2020, 69 DOI: 10.2337/db20-1772-p.Peer-Reviewed Original ResearchBrain glucose levelsPoor glycemic controlGlycemic controlGlucose levelsCentral nervous system complicationsNervous system complicationsBrain glucose transportPlasma glucose levelsContinuous glucose monitoringUncontrolled T2DMT2DM subjectsSystem complicationsBMI changeHyperglycemic clampHealthy controlsDiabetes regimenPost interventionHierarchical linear regression modelsGlucose time coursesMagnetic resonance spectroscopyHbA1cGlucose kineticsGlucose monitoringNational InstituteT2DM
2011
Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla
Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF. Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla. Biological Psychiatry 2011, 71: 239-246. PMID: 21855054, PMCID: PMC3227760, DOI: 10.1016/j.biopsych.2011.06.026.Peer-Reviewed Original ResearchConceptsIntravenous ethanol infusionProton magnetic resonance spectroscopyEthanol infusionNAA levelsN-acetylaspartateCortical γ-aminobutyric acidAcute pharmacologic effectsLevels of GABAHealthy social drinkersBreath alcohol levelsN-acetylaspartyl-glutamateCortical GABAEthanol modulatesFirst infusionΓ-aminobutyric acidGABA levelsPharmacologic effectsBrain ethanolOccipital GABAInfusionAlcohol levelsMagnetic resonance spectroscopyReceptor functionBreath ethanolHuman cortex
2009
Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy
Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF. Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 2009, 30: 211-221. PMID: 19794401, PMCID: PMC2949111, DOI: 10.1038/jcbfm.2009.197.Peer-Reviewed Original ResearchConceptsNeuronal mitochondrial metabolismHealthy agingBrain mitochondrial metabolismElderly subjectsYoung subjectsBrain functionBrain mitochondrial functionGlutamate-glutamine cyclingMitochondrial metabolismVivo magnetic resonance spectroscopyAge-related changesChronic reductionLabeling of glutamineGlutamate concentrationYoung volunteersBiologic basisMagnetic resonance spectroscopyMitochondrial functionMetabolismSubjectsIndividual subjectsResonance spectroscopyTricarboxylic acid cycleCycle fluxAging
2006
Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1‐13C] and [2‐13C] glucose
Mason GF, Petersen KF, De Graaf RA, Shulman GI, Rothman DL. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1‐13C] and [2‐13C] glucose. Journal Of Neurochemistry 2006, 100: 73-86. PMID: 17076763, PMCID: PMC2995551, DOI: 10.1111/j.1471-4159.2006.04200.x.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexCerebral cortexArterial-venous differencesAwake humansNeurotransmitter cyclingGlutamine effluxNeurotransmitter traffickingOccipital-parietal regionsGlutamateCortexPyruvate carboxylase fluxRecent studiesGlutamine synthesisPyruvate carboxylaseMagnetic resonance spectroscopyMost studiesGlutaminePyruvate dehydrogenaseIncreased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes
Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes. Diabetes 2006, 55: 929-934. PMID: 16567513, PMCID: PMC2995526, DOI: 10.2337/diabetes.55.04.06.db05-1325.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetic subjectsControl subjectsType 1 diabetic subjectsInsulin-induced hypoglycemiaNondiabetic control subjectsMonocarboxylic acid transportBrain utilizationSimilar twofold increaseBrain energeticsHypoglycemiaType 1DiabetesOxidative metabolismNonglucose substratesBrainMetabolic substratesUpregulationPatientsAcid transportTwofold increaseSubjectsMagnetic resonance spectroscopyLactateMetabolism