1998
Methadone Effects on Zidovudine Disposition (AIDS Clinical Trials Group 262)
McCanceKatz E, Rainey P, Jatlow P, Friedland G. Methadone Effects on Zidovudine Disposition (AIDS Clinical Trials Group 262). JAIDS Journal Of Acquired Immune Deficiency Syndromes 1998, 18: 435-443. PMID: 9715839, DOI: 10.1097/00042560-199808150-00004.Peer-Reviewed Original ResearchConceptsInjection drug usersMethadone treatmentChronic methadone treatmentMethadone-maintained patientsHeroin-addicted patientsMethadone effectsZDV doseZDV exposureZDV pharmacokineticsZDV treatmentZidovudine dispositionZidovudine therapyHIV diseaseMethadone levelsPharmacokinetic interactionsTherapeutic rangeRenal clearanceToxicity surveillanceSide effectsDrug usersDrug efficacyZDVClearanceAUCPatients
1989
Risk Factors for Human Immunodeficiency Virus Infection in Intravenous Drug Users
Schoenbaum E, Hartel D, Selwyn P, Klein R, Davenny K, Rogers M, Feiner C, Friedland G. Risk Factors for Human Immunodeficiency Virus Infection in Intravenous Drug Users. New England Journal Of Medicine 1989, 321: 874-879. PMID: 2770823, DOI: 10.1056/nejm198909283211306.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionIntravenous drug usersPercentage of injectionsRisk factorsHIV antibodiesDrug usersIntravenous drugsVirus infectionSex partnersSeroprevalence of HIVIndependent risk factorOnly risk factorMethadone treatment programsNumber of injectionsNon-Hispanic whitesHeterosexual sex partnersHIV infectionLast injectionUsed needlesHigh seroprevalenceDrug useShooting galleriesHIVInfectionProspective Study of Human Immunodeficiency Virus Infection and Pregnancy Outcomes in Intravenous Drug Users
Selwyn P, Schoenbaum E, Davenny K, Robertson V, Feingold A, Shulman J, Mayers M, Klein R, Friedland G, Rogers M. Prospective Study of Human Immunodeficiency Virus Infection and Pregnancy Outcomes in Intravenous Drug Users. JAMA 1989, 261: 1289-1294. PMID: 2915455, DOI: 10.1001/jama.1989.03420090053030.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionPregnancy outcomesDrug usersVirus infectionFemale intravenous drug usersHIV disease statusSeropositive pregnant womenAdverse pregnancy outcomesAsymptomatic HIV infectionNeonatal complicationsEctopic pregnancyPreterm deliveryHIV antibodiesBreech presentationHIV infectionSymptomatic diseaseBacterial pneumoniaHIV statusPregnant womenProspective studyWeight birthsAdditional womenMethadone programsA Prospective Study of the Risk of Tuberculosis among Intravenous Drug Users with Human Immunodeficiency Virus Infection
Selwyn P, Hartel D, Lewis V, Schoenbaum E, Vermund S, Klein R, Walker A, Friedland G. A Prospective Study of the Risk of Tuberculosis among Intravenous Drug Users with Human Immunodeficiency Virus Infection. New England Journal Of Medicine 1989, 320: 545-550. PMID: 2915665, DOI: 10.1056/nejm198903023200901.Peer-Reviewed Original ResearchConceptsHIV-seropositive subjectsIntravenous drug usersPositive PPD testHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionActive tuberculosisPPD testDrug usersSeronegative subjectsSeropositive subjectsTuberculous infectionSkin testingVirus infectionHIV-seronegative intravenous drug usersHIV-seronegative subjectsLatent tuberculous infectionRisk of tuberculosisTuberculin skin testingCases of tuberculosisMethadone maintenance programHIV antibodiesHIV-seropositiveHIV infectionProspective studyProtein derivative (PPD) tuberculin
1988
Increased risk of bacterial pneumonia in HIV-infected intravenous drug users without AIDS
Selwyn P, Feingold A, Hartel D, Schoenbaum E, Alderman M, Klein R, Friedland G. Increased risk of bacterial pneumonia in HIV-infected intravenous drug users without AIDS. AIDS 1988, 2: 267-272. PMID: 3140832, DOI: 10.1097/00002030-198808000-00005.Peer-Reviewed Original ResearchConceptsIntravenous drug usersIntravenous drug useBacterial pneumoniaHIV infectionDrug usersDrug useActive intravenous drug useCommunity-acquired bacterial pneumoniaCumulative yearly incidenceMethadone maintenance programSeronegative subjectsSeropositive patientsSeropositive subjectsStudy entryOpportunistic infectionsYearly incidencePneumoniaHemophilus influenzaeStreptococcus pneumoniaeSeropositivesHIVAIDSInfectionStudy periodIncidenceAIDS and Compassion
Friedland G. AIDS and Compassion. JAMA 1988, 259: 2898-2899. PMID: 3367458, DOI: 10.1001/jama.1988.03720190066034.Peer-Reviewed Original ResearchTransmission of the human immunodeficiency virus: an updated review.
Friedland G, Klein R. Transmission of the human immunodeficiency virus: an updated review. International Nursing Review 1988, 35: 44-52, 54. PMID: 3283068.Peer-Reviewed Original Research
1987
Transmission of the Human Immunodeficiency Virus
Friedland G, Klein R. Transmission of the Human Immunodeficiency Virus. New England Journal Of Medicine 1987, 317: 1125-1135. PMID: 3309656, DOI: 10.1056/nejm198710293171806.Peer-Reviewed Original ResearchInability to predict diagnosis in febrile intravenous drug abusers.
Marantz P, Linzer M, Feiner C, Feinstein S, Kozin A, Friedland G. Inability to predict diagnosis in febrile intravenous drug abusers. Annals Of Internal Medicine 1987, 106: 823-8. PMID: 3579068, DOI: 10.7326/0003-4819-106-6-823.Peer-Reviewed Original ResearchConceptsIntravenous drug abusersFinal diagnosisEmergency roomTrivial illnessDrug abusersDistribution of diseaseInfective endocarditisConsecutive admissionsPhysicians' predictionsClinical dataDiagnostic predictionClinical informationPredictive valuePatientsDiagnosisIllnessLaboratory dataEndocarditisAbusersHospitalizationPneumoniaAdmissionFeverDiseaseThe Acquired Immunodeficiency Syndrome: General Overview
Friedland G. The Acquired Immunodeficiency Syndrome: General Overview. International Journal Of Neuroscience 1987, 32: 677-686. PMID: 3647936, DOI: 10.3109/00207458709043322.Peer-Reviewed Original ResearchSerologic, Immunologic, and Clinical Features of Parenteral Drug Users from Contrasting Populations
Shine D, Moll B, Emeson E, Spigland I, Harris C, Small C, Friedland G, Weiss S, Bodner A. Serologic, Immunologic, and Clinical Features of Parenteral Drug Users from Contrasting Populations. The American Journal Of Drug And Alcohol Abuse 1987, 13: 401-412. PMID: 2961253, DOI: 10.3109/00952998709001524.Peer-Reviewed Original ResearchConceptsT cell ratioParenteral drug usersDrug usersSeropositive patientsDevelopment of AIDSOral thrushClinical featuresHealthy outpatientsHTLV antibodiesClinical evidenceHTLV-IIIPatientsPositive ELISAAbnormal ratioAIDSWeight lossAntibodiesInpatientsDifferent risksLow ratioELISAMonthsOutpatientsImmunodeficiencySerology
1985
Intravenous drug abusers and the acquired immunodeficiency syndrome (AIDS). Demographic, drug use, and needle-sharing patterns.
Friedland G, Harris C, Butkus-Small C, Shine D, Moll B, Darrow W, Klein R. Intravenous drug abusers and the acquired immunodeficiency syndrome (AIDS). Demographic, drug use, and needle-sharing patterns. JAMA Internal Medicine 1985, 145: 1413-7. PMID: 3875327, DOI: 10.1001/archinte.145.8.1413.Peer-Reviewed Original ResearchConceptsDrug abuser patientsIntravenous drug abusersDrug abusersImmunodeficiency syndromeNeedle sharingHomosexual menPutative AIDS agentPercent of patientsEvidence of AIDSBlood-borne routeDrug use patternsDrug use practicesARC patientsSexual habitsDrug usePatientsShooting galleriesSpread of AIDSAIDS agentsAIDSAIDS transmissionMale homosexualsDemographic characteristicsAbusersSyndrome