Global Morbidity and Mortality of Leptospirosis: A Systematic Review
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLOS Neglected Tropical Diseases 2015, 9: e0003898. PMID: 26379143, PMCID: PMC4574773, DOI: 10.1371/journal.pntd.0003898.Peer-Reviewed Original ResearchConceptsCase fatality ratioDisease morbidityFatality ratioSystematic reviewMortality of leptospirosisPulmonary hemorrhage syndromeBurden of leptospirosisLife-threatening diseaseDiverse epidemiological settingsResource-poor countriesNumber of deathsHigh morbidityGlobal morbidityGBD regionsGlobal burdenMorbidityZoonotic causesHaemorrhagic feverMortality studyUrban slum dwellersImportant causeDisease statusEpidemiological settingsDisease incidenceWHO regionsPatterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission
Costa F, Wunder EA, De Oliveira D, Bisht V, Rodrigues G, Reis MG, Ko AI, Begon M, Childs JE. Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission. PLOS Neglected Tropical Diseases 2015, 9: e0003819. PMID: 26047009, PMCID: PMC4457861, DOI: 10.1371/journal.pntd.0003819.Peer-Reviewed Original ResearchConceptsLeptospiral loadHuman infectionsNorway ratsEssential epidemiological informationAge of ratsSpirochetal loadPositive kidneysLeptospiral carriageMAT titersHigh riskLeptospiral infectionEpidemiological informationSignificant positive correlationUrine samplesRatsInfectionMultivariate modelingUrineDisease transmissionKidneyRiskGenome equivalentsSlum communitiesRat populationsLeptospires