2012
Anaplasma phagocytophilum Asp14 Is an Invasin That Interacts with Mammalian Host Cells via Its C Terminus To Facilitate Infection
Kahlon A, Ojogun N, Ragland SA, Seidman D, Troese MJ, Ottens AK, Mastronunzio JE, Truchan HK, Walker NJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum Asp14 Is an Invasin That Interacts with Mammalian Host Cells via Its C Terminus To Facilitate Infection. Infection And Immunity 2012, 81: 65-79. PMID: 23071137, PMCID: PMC3536139, DOI: 10.1128/iai.00932-12.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnaplasma phagocytophilumAnimalsBacterial Outer Membrane ProteinsBinding SitesCell AdhesionCell Line, TumorEhrlichiaEhrlichiosisGene Expression Regulation, BacterialGlutathione TransferaseHL-60 CellsHumansMembrane GlycoproteinsMembrane ProteinsMiceMolecular Sequence DataProtein BindingProtein Structure, TertiaryProteomeSequence Analysis, ProteinTranscription, GeneticUp-RegulationConceptsMammalian host cellsHost cellsReticulate cellsOuter membrane protein candidatesSurface proteinsOuter membrane protein AMembrane protein AA. phagocytophilum-infected ticksObligate intracellular bacteriumA. phagocytophilumGlutathione S-transferaseTranscriptional profilingSurface proteomeC-terminusAffinity purificationFamily AnaplasmataceaeProtein candidatesSelective biotinylationCellular invasionAsp14Transmission feedingAmino acidsS-transferaseIntracellular bacteriumP-selectin glycoprotein ligand-1
2005
Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum
Pedra JH, Sukumaran B, Carlyon JA, Berliner N, Fikrig E. Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum. Genomics 2005, 86: 365-377. PMID: 16005178, DOI: 10.1016/j.ygeno.2005.05.008.Peer-Reviewed Original ResearchConceptsCell machineryA. phagocytophilum infectionTwo-dimensional differential gel electrophoresisSignal transduction genesNB4 promyelocytic leukemic cellsHigh-density oligoarraysDifferential gel electrophoresisPhagocytophilum infectionIron metabolism genesNF-kappaB genesTransduction genesObligate intracellular bacteriumApoptotic programTranscription factorsNegative obligate intracellular bacteriumCell adhesion moleculeAnaplasma phagocytophilumAntiapoptotic genesGenesIntracellular bacteriumNB4 cellsAffymetrix dataGel electrophoresisTranscriptionPromyelocytic leukemic cells