2023
Dome1–JAK–STAT signaling between parasite and host integrates vector immunity and development
Rana V, Kitsou C, Dutta S, Ronzetti M, Zhang M, Bernard Q, Smith A, Tomás-Cortázar J, Yang X, Wu M, Kepple O, Li W, Dwyer J, Matias J, Baljinnyam B, Oliver J, Rajeevan N, Pedra J, Narasimhan S, Wang Y, Munderloh U, Fikrig E, Simeonov A, Anguita J, Pal U. Dome1–JAK–STAT signaling between parasite and host integrates vector immunity and development. Science 2023, 379: eabl3837. PMID: 36634189, PMCID: PMC10122270, DOI: 10.1126/science.abl3837.Peer-Reviewed Original ResearchConceptsBlood meal acquisitionMetazoan developmentTick receptorArthropod immunityMammalian hostsSignaling pathwaysReceptor motifEvolutionary dependenceVectorial competenceStem cellsCommunication pathwaysPathwayCritical roleVector immunityHostHigh affinityGenomeAntimicrobial componentsHedgehogJAKMotifMetamorphosisImmunityParasitesPhysiology
2018
Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance
Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends In Immunology 2018, 39: 862-873. PMID: 30301592, PMCID: PMC6218297, DOI: 10.1016/j.it.2018.09.003.Peer-Reviewed Original ResearchConceptsVector immunityEvolutionary ecologyEvolutionary forcesEvolutionary ecologistsGenetic plasticityVector-borne pathogensArthropod populationsAbiotic factorsMolecular immunologistsMicrobial assaultImmune systemInnate defenseRecent scientific breakthroughsEcologyEcologistsImmune responsePathogenicityImmunityPathogensPlasticityDefenseToleranceResistanceScientific breakthroughs