2007
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis
Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. Journal Of Experimental Medicine 2007, 205: 133-141. PMID: 18166585, PMCID: PMC2234379, DOI: 10.1084/jem.20070962.Peer-Reviewed Original ResearchConceptsLyme arthritisMouse jointsB. burgdorferi antigensBurgdorferi-infected miceSevere arthritisSpirochete numbersArthritisHost responseLyme diseaseAffinity-purified antibodiesBorrelia burgdorferiChain reactionMiceOriginal phenotypeBasic membrane proteinMutant spirochetesGene expressionJointsInflammationPathogenesisAntigenDiseaseB. burgdorferi gene expression
2005
Association of Linear Plasmid 28-1 with an Arthritic Phenotype of Borrelia burgdorferi
Xu Q, Seemanapalli SV, Lomax L, McShan K, Li X, Fikrig E, Liang FT. Association of Linear Plasmid 28-1 with an Arthritic Phenotype of Borrelia burgdorferi. Infection And Immunity 2005, 73: 7208-7215. PMID: 16239515, PMCID: PMC1273894, DOI: 10.1128/iai.73.11.7208-7215.2005.Peer-Reviewed Original ResearchConceptsSevere combined immunodeficiencyArthritic phenotypeLp28-1Linear plasmid 28Borrelia burgdorferiArthritic pathologySevere arthritisSpirochete burdenSCID miceJoint tissuesLoss of plasmidsCombined immunodeficiencyPlasmid content analysisLyme disease spirocheteInfectivity studiesPlasmid patternsDecreased infectivityVirulence factorsFurther studiesMiceBurgdorferiBacterial quantificationPathogenicity studiesTissuePhenotype