1997
B7-1 and B7-2 monoclonal antibodies modulate the severity of murine Lyme arthritis
Anguita J, Roth R, Samanta S, Gee RJ, Barthold SW, Mamula M, Fikrig E. B7-1 and B7-2 monoclonal antibodies modulate the severity of murine Lyme arthritis. Infection And Immunity 1997, 65: 3037-3041. PMID: 9234751, PMCID: PMC175428, DOI: 10.1128/iai.65.8.3037-3041.1997.Peer-Reviewed Original ResearchConceptsLyme arthritisMurine Lyme arthritisB7-1Monoclonal antibodiesCostimulatory moleculesB7-2Immune responseInterleukin-4C3H/HeN miceB7-2 costimulatory moleculesExperimental Lyme arthritisB7-2 expressionMurine Lyme borreliosisDegree of arthritisBorrelia burgdorferi infectionSplenocyte proliferative responseDose-dependent increaseHost immune responseT cell differentiationIL-10Antibody levelsIL-12HeN miceBurgdorferi infectionProliferative response
1994
Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors
Roessner K, Russell J, Cooper S, Budd R, Fikrig E, Flavell R. Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors. European Journal Of Immunology 1994, 24: 320-324. PMID: 7905415, DOI: 10.1002/eji.1830240207.Peer-Reviewed Original ResearchConceptsMemory T cellsT cellsPeripheral bloodB. burgdorferiProliferative responseNormal individualsPeripheral blood T cellsT lymphocyte responsesT cell responsesBlood T cellsNaive T cellsNormal adult peripheral bloodHLA-DR moleculesT cell clonesAdult peripheral bloodLyme disease patientsMultiple antigenic epitopesLymphocyte responsesSuperantigen responseUnexposed donorsMemory subsetsDisease patientsCord bloodLipopolysaccharide effectsCell responses
1992
Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens
de Souza M, Fikrig E, Smith A, Flavell R, Barthold SW. Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens. The Journal Of Infectious Diseases 1992, 165: 471-478. PMID: 1531672, DOI: 10.1093/infdis/165.3.471.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial ProteinsBacterial VaccinesBorrelia burgdorferi GroupDose-Response Relationship, ImmunologicFlow CytometryImmunoglobulin GImmunoglobulin MLipopolysaccharidesLipoproteinsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C3HRecombinant ProteinsSpecific Pathogen-Free OrganismsConceptsBorrelia burgdorferi antigensNaive splenocytesNonspecific proliferationProliferative responseB. burgdorferiC3H/HeNCrlBR miceRecombinant outer surface proteinB cell-enriched fractionC3H/HeJ miceNonspecific proliferative responseAntigen-specific proliferationStrains of miceCell-enriched fractionB. burgdorferi spirochetesIgG synthesisHeJ miceB cellsMitogenic effectOuter surface proteinsMurine lymphocytesLyme borreliosisMiceSplenocytesBurgdorferiAntigen