2018
Type I interferons instigate fetal demise after Zika virus infection
Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.Peer-Reviewed Original ResearchConceptsZika virus infectionZIKV infectionI IFNsI interferonType I interferonGrowth restrictionFetal demiseVirus infectionSevere fetal growth restrictionType I IFNsChorionic villous explantsAdverse fetal outcomesCongenital viral infectionFetal growth restrictionMaternal-fetal barrierType IFunctional type IPlacental damageFetal outcomesPregnancy complicationsEarly pregnancyFetal resorptionZIKV diseasePregnant damsSpontaneous abortion
2016
Zika virus productively infects primary human placenta-specific macrophages
Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E. Zika virus productively infects primary human placenta-specific macrophages. JCI Insight 2016, 1: e88461. PMID: 27595140, PMCID: PMC5007065, DOI: 10.1172/jci.insight.88461.Peer-Reviewed Original ResearchZika virus infectionHofbauer cellsVirus infectionFetal brainZika virusTerm placental villous explantsHuman placental macrophagesPlacental villous explantsPregnancy complicationsPlacental macrophagesPlacental barrierVillous explantsInfectious virusVillous fibroblastsCongenital defectsInfectionStrong associationMigratory activityVirusMacrophagesBrainCell typesCellsComplicationsFlaviviruses