2019
Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist
Hwang J, Wang Y, Fikrig E. Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist. Antimicrobial Agents And Chemotherapy 2019, 63: 10.1128/aac.01220-19. PMID: 31307983, PMCID: PMC6709483, DOI: 10.1128/aac.01220-19.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsApolipoproteins EATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1Chikungunya virusCholesterolFibroblastsGene Expression RegulationHost-Pathogen InteractionsHumansIndazolesInterferonsLiver X ReceptorsPrimary Cell CultureRNA, Small InterferingSignal TransductionVirus ReplicationConceptsChikungunya virusLiver X receptor agonistMosquito-borne chikungunya virusX receptor agonistLiver X receptorChikungunya Virus ReplicationLXR-623Acute painJoint inflammationReceptor agonistCHIKV replicationPharmacological activationSynthetic agonistsAntiviral stateVirus replicationX receptorLarge epidemicsHost factorsAgonistsPrimary human fibroblastsVirusHuman fibroblastsPainInflammationGeographic areas
2018
Rev-erb Agonist Inhibits Chikungunya and O’nyong’nyong Virus Replication
Hwang J, Jiang A, Fikrig E. Rev-erb Agonist Inhibits Chikungunya and O’nyong’nyong Virus Replication. Open Forum Infectious Diseases 2018, 5: ofy315. PMID: 30568983, PMCID: PMC6293476, DOI: 10.1093/ofid/ofy315.Peer-Reviewed Original ResearchChikungunya virusSubset of patientsRecent global epidemicJoint painStructural protein synthesisSevere inflammationInflammatory responseMultiple alphavirusesViral RNA accumulationGlobal epidemicSynthetic agonistsVirus replicationCultured murine macrophagesMurine macrophagesSR9009AlphavirusesRelated virusesVirusProtein synthesisPainInflammationPatientsAgonistsMacrophagesRNA accumulation