2009
Passage through Ixodes scapularis Ticks Enhances the Virulence of a Weakly Pathogenic Isolate of Borrelia burgdorferi
Adusumilli S, Booth CJ, Anguita J, Fikrig E. Passage through Ixodes scapularis Ticks Enhances the Virulence of a Weakly Pathogenic Isolate of Borrelia burgdorferi. Infection And Immunity 2009, 78: 138-144. PMID: 19822652, PMCID: PMC2798202, DOI: 10.1128/iai.00470-09.Peer-Reviewed Original ResearchConceptsIxodes scapularis ticksCommon tick-borne illnessScapularis ticksTick-borne illnessB. burgdorferi sensu strictoC3H miceBurgdorferi sensu strictoLyme diseaseMiceHigh expression levelsBorrelia burgdorferiB. burgdorferiTick engorgementExpression levelsSpirochetesDiseaseArray analysisSyringe inoculationBurgdorferiPathogenic isolatesIsolatesI. scapularisArthritisVirulencePathogenesis
2006
Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis
Hovius JW, Li X, Ramamoorthi N, Van Dam AP, Barthold SW, Van Der Poll T, Speelman P, Fikrig E. Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis. Pathogens And Disease 2006, 49: 224-234. PMID: 17328756, DOI: 10.1111/j.1574-695x.2006.00177.x.Peer-Reviewed Original ResearchConceptsMurine Lyme borreliosisB. burgdorferi sensu strictoBurgdorferi sensu strictoLyme borreliosisBorrelia burgdorferi sensu strictoEffect of coinfectionCoinfected miceBorrelia speciesSimultaneous infectionMiceCoinfectionBorreliosisB. gariniiBorrelia gariniiReservoir hostsGariniiI. ricinus populationsSpirochetesHigher numberArthritisPreferential maintenanceInfectionPrevalenceSpirochetemia
2001
Inhibition of Borrelia burgdorferi-Tick Interactions In Vivo by Outer Surface Protein A Antibody
Pal U, Montgomery R, Lusitani D, Voet P, Weynants V, Malawista S, Lobet Y, Fikrig E. Inhibition of Borrelia burgdorferi-Tick Interactions In Vivo by Outer Surface Protein A Antibody. The Journal Of Immunology 2001, 166: 7398-7403. PMID: 11390491, DOI: 10.4049/jimmunol.166.12.7398.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntibodies, BacterialAntibodies, MonoclonalAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBinding Sites, AntibodyBorrelia burgdorferi GroupDigestive SystemEpitopesFemaleImmune SeraInjections, IntraperitonealInjections, SubcutaneousIxodesLipoproteinsLyme DiseaseLyme Disease VaccinesMiceMice, SCIDMutationProtein Structure, TertiaryRecombinant ProteinsConceptsB. burgdorferi sensu strictoBurgdorferi sensu strictoB. burgdorferi N40Treatment of miceOuter Surface ProteinsB. burgdorferi sensu lato genospeciesSurface protein AOuter surface protein ASCID miceMurine modelB. burgdorferi attachmentLyme diseaseMiceB. burgdorferiBorrelia afzeliiB. afzeliiTick gutBorrelia gariniiOspAVivoAdherenceAntiserumPresent studySurface proteinsGut
1996
Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans
Anderson JF, Flavell RA, Magnarelli LA, Barthold SW, Kantor FS, Wallich R, Persing DH, Mathiesen D, Fikrig E. Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans. Journal Of Clinical Microbiology 1996, 34: 524-529. PMID: 8904407, PMCID: PMC228839, DOI: 10.1128/jcm.34.3.524-529.1996.Peer-Reviewed Original ResearchConceptsLate Lyme diseaseBorrelia burgdorferiScapularis ticksPulsed-field gel electrophoresis patternsWhite-footed miceIxodes scapularis ticksB. burgdorferi sensu strictoI. scapularis ticksBurgdorferi sensu strictoLyme diseaseMonoclonal antibodiesGel electrophoresis patternsI. scapularisRestriction fragment length polymorphismFragment length polymorphismMicePrevious isolatesZS7Strain B31