2004
Increase in Sexual Risk Behavior Associated with Immunologic Response to Highly Active Antiretroviral Therapy among HIV-Infected Injection Drug Users
Tun W, Gange S, Vlahov D, Strathdee S, Celentano D. Increase in Sexual Risk Behavior Associated with Immunologic Response to Highly Active Antiretroviral Therapy among HIV-Infected Injection Drug Users. Clinical Infectious Diseases 2004, 38: 1167-1174. PMID: 15095224, DOI: 10.1086/383033.Peer-Reviewed Original ResearchConceptsInjection drug usersActive antiretroviral therapyHAART initiationCell countAntiretroviral therapyDrug usersSexual intercourseRisk reduction counselingHuman immunodeficiency virusLarge cohort studyDrug injection behaviorInjection of drugsUnprotected sexual intercourseSemiannual visitsReduction counselingCohort studyHIV infectionHIV serostatusImmunodeficiency virusImmunologic responseNeedle sharingBlood samplesSurvival analysisRisk behaviorsCD4
2003
Variability in the Incidence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infection among Young Injecting Drug Users in New York City
Des Jarlais D, Diaz T, Perlis T, Vlahov D, Maslow C, Latka M, Rockwell R, Edwards V, Friedman S, Monterroso E, Williams I, Garfein R. Variability in the Incidence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infection among Young Injecting Drug Users in New York City. American Journal Of Epidemiology 2003, 157: 467-471. PMID: 12615611, DOI: 10.1093/aje/kwf222.Peer-Reviewed Original ResearchConceptsHepatitis B virusHuman immunodeficiency virusHepatitis C virusImmunodeficiency virusB virusDrug usersHepatitis C virus infectionC virus infectionInjecting Drug UsersHigh HIV seroprevalenceHigh rateHBV incidenceHCV incidenceHCV transmissionCohort studyHIV seroprevalenceHIV incidenceHIV transmissionYoung Injecting Drug UsersC virusVirus infectionNew York CityIncidenceVirusYork City
2001
Cancer incidence in women with or at risk for HIV
Phelps R, Smith D, Heilig C, Gardner L, Carpenter C, Klein R, Jamieson D, Vlahov D, Schuman P, Holmberg S, Group S. Cancer incidence in women with or at risk for HIV. International Journal Of Cancer 2001, 94: 753-757. PMID: 11745473, DOI: 10.1002/ijc.1528.Peer-Reviewed Original ResearchConceptsInvasive cervical cancerLung cancerHigh-risk human immunodeficiency virusRace-matched womenCurrent antiretroviral therapyHistory of smokingMonths of diagnosisInjection drug useHuman immunodeficiency virusHIV Epidemiology Research StudyCare of womenRates of cancerCancer incidence dataInterval diagnosisUninfected womenAntiretroviral therapyHIV infectionStudy closureCervical cancerImmunodeficiency virusYoung smokersHodgkin's lymphomaMedical recordsCancer incidenceKaposi's sarcomaIsoniazid Preventive Therapy, Hepatitis C Virus Infection, and Hepatotoxicity among Injection Drug Users Infected with Mycobacterium tuberculosis
Sadaphal P, Astemborski J, Graham N, Sheely L, Bonds M, Madison A, Vlahov D, Thomas D, Sterling T. Isoniazid Preventive Therapy, Hepatitis C Virus Infection, and Hepatotoxicity among Injection Drug Users Infected with Mycobacterium tuberculosis. Clinical Infectious Diseases 2001, 33: 1687-1691. PMID: 11641824, PMCID: PMC2650436, DOI: 10.1086/323896.Peer-Reviewed Original ResearchConceptsHepatitis C virusInjection drug usersTuberculosis infectionValue elevationDrug usersCurrent injection drug useLatent Mycobacterium tuberculosis infectionHepatitis C virus infectionHepatitis B surface antigenLow HCV prevalenceC virus infectionIsoniazid preventive therapyInjection drug useM. tuberculosis infectionMycobacterium tuberculosis infectionHIV-1 infectionHuman immunodeficiency virusB surface antigenConcurrent alcohol useDrug discontinuationHCV prevalencePreventive therapyImmunodeficiency virusProspective studyTransaminase valuesHuman Immunodeficiency Virus Seroconversion and Evolution of the Hepatitis C Virus Quasispecies
Mao Q, Ray S, Laeyendecker O, Ticehurst J, Strathdee S, Vlahov D, Thomas D. Human Immunodeficiency Virus Seroconversion and Evolution of the Hepatitis C Virus Quasispecies. Journal Of Virology 2001, 75: 3259-3267. PMID: 11238852, PMCID: PMC114119, DOI: 10.1128/jvi.75.7.3259-3267.2001.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHCV quasispeciesHypervariable region 1HIV seroconversionChronic hepatitis C virus (HCV) infectionE2 hypervariable region 1Hepatitis C virus infectionHuman immunodeficiency virus (HIV) seroconversionRapid HIV disease progressionHepatitis C virus quasispeciesHIV infection altersHIV-associated diseaseChronic HCV infectionC virus infectionHIV disease progressionHCV infectionHCV RNASerum levelsLiver diseaseImmunodeficiency virusDisease progressionRapid progressionVirus infectionNumber of subjectsHCV sequencesMortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women: Longitudinal Analysis From the HIV Epidemiology Research Study
Ickovics J, Hamburger M, Vlahov D, Schoenbaum E, Schuman P, Boland R, Moore J, Group F. Mortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women: Longitudinal Analysis From the HIV Epidemiology Research Study. JAMA 2001, 285: 1466-1474. PMID: 11255423, DOI: 10.1001/jama.285.11.1466.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusChronic depressive symptomsCD4 cell countHIV-seropositive womenTreatment of depressionDepressive symptomsCell countDisease progressionBaseline CD4 cell countCD4 cell count declineHIV Epidemiologic Research StudyCell count declineCD4 lymphocyte countBaseline viral loadEpidemiologic Studies Depression ScaleHIV disease progressionHIV Epidemiology Research StudyLongitudinal cohort studyEpidemiologic research studiesImpact of depressionAcademic medical centerSelf-reported CenterCohort studyLymphocyte countCount declineBlood-Borne and Sexual Transmission of Human Herpesvirus 8 in Women with or at Risk for Human Immunodeficiency Virus Infection
Cannon M, Dollard S, Smith D, Klein R, Schuman P, Rich J, Vlahov D, Pellett P. Blood-Borne and Sexual Transmission of Human Herpesvirus 8 in Women with or at Risk for Human Immunodeficiency Virus Infection. New England Journal Of Medicine 2001, 344: 637-643. PMID: 11228278, DOI: 10.1056/nejm200103013440904.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBlood-Borne PathogensFemaleHepatitis, Viral, HumanHerpesviridae InfectionsHerpesvirus 8, HumanHeterosexualityHIV InfectionsHumansLogistic ModelsProspective StudiesRisk FactorsRisk-TakingSeroepidemiologic StudiesSexual BehaviorSubstance Abuse, IntravenousSyphilisConceptsInjection drug useHHV-8 infectionHepatitis B virusHepatitis C virusHuman immunodeficiency virusHHV-8 seroprevalenceHHV-8Human herpesvirus 8Sexual transmissionRisk factorsHerpesvirus 8Human immunodeficiency virus (HIV) infectionHHV-8 seropositivityHigh-risk sexual behaviorImmunodeficiency virus infectionBlood-borne transmissionDaily injection drug useHispanic ethnic backgroundEnzyme-linked immunosorbentRisk of seropositivityBlood borneSyphilis infectionHIV infectionIndependent predictorsImmunodeficiency virus
2000
New York State pharmacists' attitudes toward needle and syringe sales to injection drug users before implementation of syringe deregulation
Linas B, Coffin P, Backes G, Vlahov D. New York State pharmacists' attitudes toward needle and syringe sales to injection drug users before implementation of syringe deregulation. Journal Of Urban Health 2000, 77: 768-780. PMID: 11194316, PMCID: PMC3456767, DOI: 10.1007/bf02344037.Peer-Reviewed Original ResearchConceptsInjection drug usersHuman immunodeficiency virusSyringe salesDrug usersImportant preventive health measurePreventive health measuresSelf-administered questionnaireImmunodeficiency virusHealth measuresSexual partnersPharmacists' attitudesNew York StatePharmacistsPreliminary dataState surveysSyringesNew York CitySimilar levelsAvailability programsLikely practiceNeedleHepatitisBaseline informationYork CityThe prevalence of homelessness among injection drug users with and without HIV infection
Song J, Safaeian M, Strathdee S, Vlahov D, Celentano D. The prevalence of homelessness among injection drug users with and without HIV infection. Journal Of Urban Health 2000, 77: 678-687. PMID: 11194310, PMCID: PMC3456762, DOI: 10.1007/bf02344031.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusInjection drug usersInjection drug useIndependent predictorsDrug usersDrug useActive injection drug useLongitudinal cohort studyCross-sectional studyHIV/AIDSCross-sectional investigationHIV seroconversionCohort studyHIV seroprevalenceHIV infectionPrevalence of homelessnessImmunodeficiency virusMale sexLogistic regressionPrevalenceParticipantsMore experiencePredictorsSeroconversionSerostatusGender differences in the initiation of injection drug use among young adults
Doherty M, Garfein R, Monterroso E, Latkin C, Vlahov D. Gender differences in the initiation of injection drug use among young adults. Journal Of Urban Health 2000, 77: 396-414. PMID: 10976613, PMCID: PMC3456045, DOI: 10.1007/bf02386749.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusInjection drug useHIV risk profilesDrug useRisk behaviorsRisk profileLow HIV prevalenceInjection drug usersMale sex partnersCommunity-based recruitmentPercentage of womenMale IDUsHIV prevalenceImmunodeficiency virusRisky injectionMost womenGender differencesDrug usersSex partnersInjection initiationYoung womenPatterns of initiationNumber of personsYoung adultsWomenThe Natural History of Hepatitis C Virus Infection: Host, Viral, and Environmental Factors
Thomas D, Astemborski J, Rai R, Anania F, Schaeffer M, Galai N, Nolt K, Nelson K, Strathdee S, Johnson L, Laeyendecker O, Boitnott J, Wilson L, Vlahov D. The Natural History of Hepatitis C Virus Infection: Host, Viral, and Environmental Factors. JAMA 2000, 284: 450-456. PMID: 10904508, DOI: 10.1001/jama.284.4.450.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseInjection drug useHepatitis C virus infectionC virus infectionHuman immunodeficiency virusViral clearanceHCV infectionLiver diseaseDrug usePersistent viremiaVirus infectionCases of ESLDRisk of ESLDCommunity-based prospective cohort studyAntibody-positive test resultPresence of ascitesProspective cohort studyCause of deathUtilization of treatmentMajority of adultsSemiannual visitsCohort studyHCV RNAEsophageal varicesImmunodeficiency virusCervical Neoplasia and Repeated Positivity of Human Papillomavirus Infection In Human Immunodeficiency Virus-seropositive and -seronegative Women
Ahdieh L, Munoz A, Vlahov D, Trimble C, Timpson L, Shah K. Cervical Neoplasia and Repeated Positivity of Human Papillomavirus Infection In Human Immunodeficiency Virus-seropositive and -seronegative Women. American Journal Of Epidemiology 2000, 151: 1148-1157. PMID: 10905527, DOI: 10.1093/oxfordjournals.aje.a010165.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiviral AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHIV SeronegativityHIV SeropositivityHumansImmunosuppression TherapyIncidenceLongitudinal StudiesPapillomaviridaePapillomavirus InfectionsRisk AssessmentSurvival AnalysisTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsConceptsCervical intraepithelial neoplasiaHuman papillomavirus infectionHPV positivityHPV clearancePapillomavirus infectionHIV infectionBiopsy-confirmed cervical intraepithelial neoplasiaAssociation of HIVPotent antiretroviral therapyCervicovaginal lavage specimensHuman immunodeficiency virusCells/Reversal of immunosuppressionPolymerase chain reaction-based assaySeronegative womenAntiretroviral therapyHIV- womenHPV resultsHIV- participantsHPV DNACervical neoplasiaHIV serostatusIntraepithelial neoplasiaImmunodeficiency virusRelated immunosuppressionDeterminants of the Quantity of Hepatitis C Virus RNA
Thomas D, Astemborski J, Vlahov D, Strathdee S, Ray S, Nelson K, Galai N, Nolt K, Laeyendecker O, Todd J. Determinants of the Quantity of Hepatitis C Virus RNA. The Journal Of Infectious Diseases 2000, 181: 844-851. PMID: 10720503, DOI: 10.1086/315314.Peer-Reviewed Original ResearchConceptsHCV RNA levelsHepatitis C virus RNAHIV-negative personsC virus RNAHCV RNARNA levelsLower HCV RNA levelsSerum HCV RNA levelsHepatitis B infectionInjection drug useHuman immunodeficiency virusVirus RNAVirologic factorsB infectionHCV infectionImmunodeficiency virusNeedle sharingBlood levelsPositive personsDrug useYounger ageInfectionEquivalents/Additional researchPerson variabilityScreening for Hepatitis C Virus in Human Immunodeficiency Virus-Infected Individuals
Thio C, Nolt K, Astemborski J, Vlahov D, Nelson K, Thomas D. Screening for Hepatitis C Virus in Human Immunodeficiency Virus-Infected Individuals. Journal Of Clinical Microbiology 2000, 38: 575-577. PMID: 10655348, PMCID: PMC86151, DOI: 10.1128/jcm.38.2.575-577.2000.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHCV RNANegative participantsHepatitis C virus antibody testHuman immunodeficiency virus-infected individualsHepatitis C virus screeningThird-generation enzyme immunoassayHIV-negative participantsVirus-infected individualsHepatitis C virusInjection drug usersThird-generation assaysCOBAS AMPLICOR systemFalse-negative testsThird-generation testsFalse-negative resultsAcute infectionHIV infectionImmunodeficiency virusC virusAntibody formationAntibody testHCVVirus screeningAmplicor system
1999
Prevalence of Lower Genital Tract Infections Among Human Immunodeficiency Virus (HIV)—Seropositive and High-Risk HIV-Seronegative Women
Cu-Uvin S, Hogan J, Warren D, Klein R, Peipert J, Schuman P, Holmberg S, Anderson J, Schoenbaum E, Vlahov D, Mayer K, Group F. Prevalence of Lower Genital Tract Infections Among Human Immunodeficiency Virus (HIV)—Seropositive and High-Risk HIV-Seronegative Women. Clinical Infectious Diseases 1999, 29: 1145-1150. PMID: 10524955, DOI: 10.1086/313434.Peer-Reviewed Original ResearchConceptsHIV-seronegative womenGenital tract infectionLower genital tract infectionHuman immunodeficiency virusTract infectionsBacterial vaginosisImmunodeficiency virusHigh-risk HIV-seronegative womenLower Genital Tract InfectionsRisk HIV-seronegative womenHuman papilloma virus infectionHIV-seropositive womenPapilloma virus infectionHigh-risk womenNeisseria gonorrhoeae infectionChlamydia trachomatis infectionHIV Epidemiology Research StudySimilar HIVSeropositive womenGonorrhoeae infectionBaseline visitTrachomatis infectionCandidal vaginitisVirus infectionInfectionSerologic evidence of rickettsialpox (Rickettsia akari) infection among intravenous drug users in inner-city Baltimore, Maryland.
Comer J, Tzianabos T, Flynn C, Vlahov D, Childs J. Serologic evidence of rickettsialpox (Rickettsia akari) infection among intravenous drug users in inner-city Baltimore, Maryland. American Journal Of Tropical Medicine And Hygiene 1999, 60: 894-8. PMID: 10403316, DOI: 10.4269/ajtmh.1999.60.894.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBaltimoreCohort StudiesCross ReactionsDrinkingFemaleFluorescent Antibody Technique, IndirectHIV SeropositivityHumansIll-Housed PersonsMaleRickettsiaRickettsia InfectionsRickettsia rickettsiiRisk FactorsSeroepidemiologic StudiesSubstance Abuse, IntravenousUrban PopulationConceptsIntravenous drug usersInner-city BaltimoreDrug usersSerologic evidenceSerum samplesAcute febrile illnessR. rickettsiiR. akariHuman immunodeficiency virusSignificant risk factorsSignificant inverse associationCross-adsorption studiesPresence of antibodiesSingle serum sampleR. akari infectionFrequency of injectionsFever group rickettsiaeFebrile illnessUndetermined etiologyImmunodeficiency virusInverse associationRisk factorsGroup-specific antibodiesDrug useHigh titersComparison between a Whole Blood Interferon-γ Release Assay and Tuberculin Skin Testing for the Detection of Tuberculosis Infection among Patients at Risk for Tuberculosis Exposure
Kimura M, Converse P, Astemborski J, Rothel J, Vlahov D, Comstock G, Graham N, Chaisson R, Bishai W. Comparison between a Whole Blood Interferon-γ Release Assay and Tuberculin Skin Testing for the Detection of Tuberculosis Infection among Patients at Risk for Tuberculosis Exposure. The Journal Of Infectious Diseases 1999, 179: 1297-1300. PMID: 10191241, DOI: 10.1086/314707.Peer-Reviewed Original ResearchConceptsTuberculin skin testIFN-gamma releaseTuberculosis infectionWhole-Blood Interferon-γ Release AssayStandard tuberculin skin testInterferon-γ release assaysPercent agreementCulture-confirmed tuberculosisHIV-seropositive subjectsTuberculin skin testingHuman immunodeficiency virusInterferon-gamma releaseIntravenous drug usersSingle blood drawSeronegative patientsTuberculosis exposureSkin testingUninfected personsImmunodeficiency virusSkin testBlood drawUrban BaltimoreDrug usersRelease assaysFurther evaluation
1998
Diversification of Subtype E Human Immunodeficiency Virus Type 1 env in Heterosexual Seroconverters from Northern Thailand
Wang Z, Lyles C, Beyrer C, Celentano D, Vlahov D, Natpratan C, Markham R, Khamboonruang C, Nelson K, Yu X. Diversification of Subtype E Human Immunodeficiency Virus Type 1 env in Heterosexual Seroconverters from Northern Thailand. The Journal Of Infectious Diseases 1998, 178: 1507-1511. PMID: 9780276, DOI: 10.1086/314441.Peer-Reviewed Original ResearchConceptsHIV-1 infectionAsymptomatic HIV-1-infected subjectsHIV-1 subtype EHIV-1-infected subjectsHuman Immunodeficiency Virus Type 1 EnvSubtype E HIVC2-V3 regionHuman immunodeficiency virusHIV vaccine developmentInjection drug usersE HIVRecent seroconvertersImmunodeficiency virusSubtype ESeroconvertersHIV-1Drug usersVaccine developmentMolecular epidemiologyEnv sequencesInfectionEnvNorthern ThailandHIVBaltimoreSelf-reported Antiretroviral Therapy in Injection Drug Users
Celentano D, Vlahov D, Cohn S, Shadle V, Obasanjo O, Moore R. Self-reported Antiretroviral Therapy in Injection Drug Users. JAMA 1998, 280: 544-546. PMID: 9707145, DOI: 10.1001/jama.280.6.544.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusInjection drug usersSelf-reported ART useAntiretroviral therapyART useDrug usersCombination therapyProtease inhibitorsRecent human immunodeficiency virusSelf-reported antiretroviral therapyInternational AIDS Society-USACurrent drug injectorsRecent antiretroviral therapyProtease inhibitor useHalf of patientsUS Public Health ServiceTriple combination therapyCommunity-based clinicsProportion of subjectsHealth care providersCurrent drug useActive drug usersCross-sectional surveyPublic health servicesInhibitor useThe role of needle exchange programs in HIV prevention.
Vlahov D, Junge B. The role of needle exchange programs in HIV prevention. Public Health Reports 1998, 113 Suppl 1: 75-80. PMID: 9722812, PMCID: PMC1307729.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusNeedle exchange programsCase-control studyNeedle exchangeHIV preventionMultiperson useNew Haven's needle exchange programDrug usersDrug useBlood-borne viral infectionsHepatitis C virus infectionSyringe-sharing behaviorsC virus infectionBlood-borne infectionsInjection drug useBlood-borne pathogensPossession of syringesSyringe trackingHCV infectionHepatitis BHIV seroincidenceHIV infectionImmunodeficiency syndromeHIV transmissionImmunodeficiency virus