2020
Novel microsimulation model of tobacco use behaviours and outcomes: calibration and validation in a US population
Reddy KP, Bulteel AJB, Levy DE, Torola P, Hyle EP, Hou T, Osher B, Yu L, Shebl FM, Paltiel AD, Freedberg KA, Weinstein MC, Rigotti NA, Walensky RP. Novel microsimulation model of tobacco use behaviours and outcomes: calibration and validation in a US population. BMJ Open 2020, 10: e032579. PMID: 32404384, PMCID: PMC7228509, DOI: 10.1136/bmjopen-2019-032579.Peer-Reviewed Original ResearchConceptsNational Health Interview SurveyCessation ratesQuit attemptsTobacco useMortality riskSmoking relapseSurveillance Modeling Network (CISNET) modelsNational Death IndexHealth Interview SurveyCigarette smoking behaviorNicotine product useExternal validationCumulative mortality curvesTobacco control policiesTobacco use behaviorsCurrent smokersDeath IndexSmoking prevalenceSustained abstinenceUS womenRelapseSmoking behaviorWomen/menUS populationNatural history
2015
Defining the Value of Future Research to Identify the Preferred Treatment of Meniscal Tear in the Presence of Knee Osteoarthritis
Losina E, Dervan EE, Paltiel AD, Dong Y, Wright RJ, Spindler KP, Mandl LA, Jones MH, Marx RG, Safran-Norton CE, Katz JN. Defining the Value of Future Research to Identify the Preferred Treatment of Meniscal Tear in the Presence of Knee Osteoarthritis. PLOS ONE 2015, 10: e0130256. PMID: 26086246, PMCID: PMC4472814, DOI: 10.1371/journal.pone.0130256.Peer-Reviewed Original Research
2014
Mobile HIV Screening in Cape Town, South Africa: Clinical Impact, Cost and Cost-Effectiveness
Bassett IV, Govindasamy D, Erlwanger AS, Hyle EP, Kranzer K, van Schaik N, Noubary F, Paltiel AD, Wood R, Walensky RP, Losina E, Bekker LG, Freedberg KA. Mobile HIV Screening in Cape Town, South Africa: Clinical Impact, Cost and Cost-Effectiveness. PLOS ONE 2014, 9: e85197. PMID: 24465503, PMCID: PMC3898963, DOI: 10.1371/journal.pone.0085197.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioFacility-based testingHIV screeningHIV diagnosisFacility-based HIV testingFrequency of HIVUndiagnosed HIV prevalenceEarly HIV diagnosisLife expectancyMobile screening unitCost-effectiveness ratioResource-limited settingsCD4 countUndiagnosed HIVHIV testingHIV prevalenceCape TownClinical impactPopulation life expectancyMedical costsHIVScreening unitIntervention costsDiagnosisMedical facilities
2008
Modeling the Potential Impact of a Prescription Drug Copayment Increase on the Adult Asthmatic Medicaid Population
Bae SJ, Paltiel AD, Fuhlbrigge AL, Weiss ST, Kuntz KM. Modeling the Potential Impact of a Prescription Drug Copayment Increase on the Adult Asthmatic Medicaid Population. Value In Health 2008, 11: 110-118. PMID: 18237365, PMCID: PMC3476042, DOI: 10.1111/j.1524-4733.2007.00219.x.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAdultAge FactorsAnti-Asthmatic AgentsAsthmaCost SharingDrug PrescriptionsHealth Services AccessibilityHumansInsurance, Pharmaceutical ServicesMassachusettsMedicaidModels, EconometricNebulizers and VaporizersOutcome Assessment, Health CareState Health PlansTreatment RefusalUnited StatesConceptsFrequent acute exacerbationsAcute exacerbationCopayment increaseHealth outcomesPrescription drug copaymentsLikely health outcomesDrug nonadherenceCorticosteroid useAdult asthmaticsAcute eventDrug utilizationMedicaid populationDrug copaymentsMedicaid beneficiariesPrescription drugsCopaymentsReimbursement ratesFinancial burdenExacerbationTarget populationFirst yearNet savingsOutcomesPharmacyCommonwealth of Massachusetts
2005
Optimal Frequency of Cd4 Cell Count and HIV Rna Monitoring Prior to Initiation of Antiretroviral Therapy in HIV-Infected Patients
Kimmel AD, Goldie SJ, Walensky RP, Losina E, Weinstein MC, Paltiel AD, Zhang H, Freedberg KA. Optimal Frequency of Cd4 Cell Count and HIV Rna Monitoring Prior to Initiation of Antiretroviral Therapy in HIV-Infected Patients. Antiviral Therapy 2005, 10: 41-52. PMID: 15751762, DOI: 10.1177/135965350501000102.Peer-Reviewed Original ResearchConceptsCD4 cell countQuality-adjusted life yearsHIV RNA monitoringAntiretroviral therapy initiationIncremental CE ratioCell countAntiretroviral therapyTherapy initiationTreatment thresholdCD4 cell count thresholdCD4 cells/mm3Initial clinical presentationCells/mm3Log10 copies/Incremental clinical benefitLife expectancyQuality-adjusted life expectancyHIV simulation modelHypothetical clinical settingsMore frequent monitoringCost-effectiveness analysisCell count thresholdAntiretroviral initiationVirological predictorsHIV RNA
2004
Association between preference-based health-related quality of life and asthma severity
Moy ML, Fuhlbrigge AL, Blumenschein K, Chapman RH, Zillich AJ, Kuntz KM, Paltiel AD, Kitch BT, Weiss ST, Neumann PJ. Association between preference-based health-related quality of life and asthma severity. Annals Of Allergy Asthma & Immunology 2004, 92: 329-334. PMID: 15049396, DOI: 10.1016/s1081-1206(10)61570-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAsthmaChoice BehaviorFemaleHealth SurveysHumansMaleMiddle AgedOutcome Assessment, Health CarePatient SatisfactionQuality of LifeSurveys and QuestionnairesConceptsPreference-based measuresHealth Utilities Index 3Standard gambleAsthma Symptom Utility IndexTime tradeoffPreference-based health-related qualityResource allocation decisionsHealth statesCost-effectiveness analysisStrength of preferenceSubject's health stateAllocation decisionsAsthma severityHealth-related qualityValues peoplePreference scoresPreference instrumentSymptom frequencyRating ScaleUtility indexAirway obstructionLung functionHUI3 scoresHealth improvementPreferences
2003
Age does not limit quality of life improvement in cardiac valve surgery
Sedrakyan A, Vaccarino V, Paltiel AD, Elefteriades JA, Mattera JA, Roumanis SA, Lin Z, Krumholz HM. Age does not limit quality of life improvement in cardiac valve surgery. Journal Of The American College Of Cardiology 2003, 42: 1208-1214. PMID: 14522482, DOI: 10.1016/s0735-1097(03)00949-5.Peer-Reviewed Original ResearchConceptsMental component summaryQuality of lifeCardiac valve surgeryPhysical component summaryValve surgeryAssociation of ageValve proceduresComponent summarySF-36PCS scoresMedical Outcomes Trust Short FormPatients' QOLMitral valve proceduresAortic valve proceduresOlder patientsAortic patientsMCS scoresMitral patientsQOL benefitsHealth SurveyPatientsSurgeryStatistical significanceAgeMultiple regression analysis