2022
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson P, Stein D, van den Heuvel O, Vriend C. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder. Translational Psychiatry 2022, 12: 70. PMID: 35190533, PMCID: PMC8861046, DOI: 10.1038/s41398-022-01823-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainChildHumansMagnetic Resonance ImagingObsessive-Compulsive DisorderThalamusConceptsObsessive-compulsive disorderMagnetic resonance imagingThalamic volumeOCD patientsThalamic subregionsT1-weighted brain magnetic resonance imagingBrain magnetic resonance imagingClinical-level symptomsLarger thalamic volumesPediatric OCD patientsAdult OCD patientsSeparate multiple linear regression modelsVolumetric group differencesThalamus sizeMedicated patientsAdolescent patientsAnterior thalamusHealthy controlsSubregional volumesGeneral populationMedication statusMultiple comparison correctionPatientsResonance imagingIntracranial volume
2021
Symptom provocation in obsessive–compulsive disorder: A voxel-based meta-analysis and meta-analytic connectivity modeling
Yu J, Zhou P, Yuan S, Wu Y, Wang C, Zhang N, Li CR, Liu N. Symptom provocation in obsessive–compulsive disorder: A voxel-based meta-analysis and meta-analytic connectivity modeling. Journal Of Psychiatric Research 2021, 146: 125-134. PMID: 34971910, DOI: 10.1016/j.jpsychires.2021.12.029.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingGray MatterHumansMagnetic Resonance ImagingMaleObsessive-Compulsive DisorderConceptsRight lateral occipital gyrusMiddle occipital gyrusMiddle cingulate cortexLateral occipital gyrusRight caudate bodyMiddle temporal gyrusObsessive-compulsive disorderInferior frontal gyrusSymptom provocationOCD patientsOrbitofrontal cortexCaudate bodyPrimary analysisThalamic-cortical circuit [CSTC] dysfunctionOccipital gyrusPosterior cortical structuresMagnetic resonance imaging studyActivation likelihood estimation algorithmHigher activationRight middle temporal gyrusRight orbitofrontal cortexLeft orbitofrontal cortexResonance imaging studyFunctional magnetic resonance imaging studyDorsal striatal activation
2013
Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder
Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBrainBrain MappingCerebellumCorpus StriatumFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysObsessive-Compulsive DisorderRestYoung AdultConceptsObsessive-compulsive disorderPrefrontal cortexResting-state functional connectivity dataStriatum/nucleus accumbensVentral striatum/nucleus accumbensResting-state functional connectivity studiesVentral anterior cingulate cortexCortico-striatal circuitsMagnetic Resonance Imaging AnalysisAnterior cingulate cortexFunctional connectivity studiesBasal gangliaControl subjectsFunctional connectivity dataAnterior thalamusRight putamenFrontal cortexNucleus accumbensDorsal striatumCerebellar cortexAbnormal neural connectivityCerebellar dysconnectivityCingulate cortexWhole brainFunctional magnetic resonance imaging (fMRI) analysis
2006
Obsessive–compulsiveness and impulsivity in a non-clinical population of adolescent males and females
Li CS, Chen SH. Obsessive–compulsiveness and impulsivity in a non-clinical population of adolescent males and females. Psychiatry Research 2006, 149: 129-138. PMID: 17046069, DOI: 10.1016/j.psychres.2006.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentDisruptive, Impulse Control, and Conduct DisordersFactor Analysis, StatisticalFemaleHumansMaleObsessive-Compulsive DisorderPrevalenceSeverity of Illness IndexSurveys and QuestionnairesConceptsMaudsley Obsessive-Compulsive InventoryLack of perseveranceBIS-11Impulsive behaviorNon-clinical adolescent populationBarratt Impulsiveness ScaleNon-clinical populationsObsessive-Compulsive InventoryBIS-11 scoresIntrusive thoughtsRepetitive checkingHigh school studentsPsychological dimensionsImpulsiveness ScaleNeurobiological basisImpulsivityOverall internal consistencyAdolescent malesGood overall internal consistencyCertain psychiatric conditionsInternal consistencyAdolescent populationPsychiatric conditionsChinese versionParticipants
2000
Perceptual alternation in obsessive compulsive disorder — implications for a role of the cortico-striatal circuitry in mediating awareness
Li C, Chen M, Yang Y, Chang H, Liu C, Shen S, Chen C. Perceptual alternation in obsessive compulsive disorder — implications for a role of the cortico-striatal circuitry in mediating awareness. Behavioural Brain Research 2000, 111: 61-69. PMID: 10840132, DOI: 10.1016/s0166-4328(00)00140-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxiety DisordersAttentionAwarenessBrain MappingCerebral CortexCorpus StriatumDepth PerceptionFemaleFrontal LobeHumansMaleNerve NetNeural InhibitionObsessive-Compulsive DisorderOptical IllusionsOrientationPattern Recognition, VisualPerceptual DisordersReaction TimeSaccadesSynaptic TransmissionConceptsCortico-striatal circuitryPerceptual alternationsPerceptual reversalsHamilton anxiety scoreFronto-striatal circuitryPerceptual alternation ratesYale-Brown Obsessive CompulsiveGeneralized anxiety disorderEtiology of OCDNormal controlsNormal subjectsAlternative perceptsFunctional aberrationsSchröder staircaseBehavioral tasksEye fixationsAnxiety disordersObsessive-CompulsiveAnxiety scoresAlternation rateBehavioral manifestationsInhibitory functionBrain statesOCDDifferent thoughts